PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32019102-0	2020	Ixazomib Improves Bone Remodeling and Counteracts sonic Hedgehog signaling Inhibition Mediated by Myeloma Cells.	ixazomib	0-8	sonic hedgehog signaling molecule	Homo sapiens	50-64	
32019102-7	2020	Given the key role of Sonic Hedgehog (SHH) signaling in bone homeostasis, we further investigated Ixazomib-induced SHH pathway activation.	ixazomib	98-106	sonic hedgehog signaling molecule	Homo sapiens	115-118	
32019102-10	2020	In conclusion, our data demonstrated that Ixazomib regulates bone remodeling by decreasing osteoclastogenesis and prompting osteoblast differentiation via the canonical SHH signaling pathway activation, thus, representing a promising therapeutic option to improve the complex pathological condition of MM patients.	ixazomib	42-50	sonic hedgehog signaling molecule	Homo sapiens	169-172