PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31466760-10 2019 However, a full LPS-induced fever was observed in tolerant rats pretreated with MK-886, which was associated with an enhancement in the hypothalamic PGE2 levels, that were not accompanied by plasma cytokines (IL-1beta, and IL-6) and PGE2 surges. MK-886 80-86 interleukin 6 Rattus norvegicus 223-227 21649921-10 2011 MK-886 also significantly decreased serum TNF-alpha & IL-6; lung MDA; BALF LTB4, LTC4 & total protein compared with the HS group (P < 0.05). MK-886 0-6 interleukin 6 Rattus norvegicus 58-62 12914802-7 2003 Blockade of 5-LOX by MK886 (200nM) abrogated LTB(4)-formation, ROS-formation, and IL-6 mRNA expression. MK-886 21-26 interleukin 6 Rattus norvegicus 82-86 1331218-6 1992 Inhibition of 5-lipoxygenase pathway by AA-861 or MK 886 inhibited the PAF-induced augmentation of both IL-6 and LTB4 production, suggesting an implication of endogenous leukotrienes in this mechanism. MK-886 50-56 interleukin 6 Rattus norvegicus 104-108