PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31897571-8 2020 reduces conditioned gaping and administration of MK886 (a peroxisome proliferator-activated receptor alpha [PPARalpha] antagonist) blocked THCA"s anti-nausea effect. MK-886 49-54 peroxisome proliferator activated receptor alpha Rattus norvegicus 58-106 31897571-8 2020 reduces conditioned gaping and administration of MK886 (a peroxisome proliferator-activated receptor alpha [PPARalpha] antagonist) blocked THCA"s anti-nausea effect. MK-886 49-54 peroxisome proliferator activated receptor alpha Rattus norvegicus 108-117 31063807-6 2019 Moreover, F215 also markedly alleviated osteoarthritic pain in rats, and the therapeutic effects of F215 were blocked by the PPAR-alpha antagonist MK886. MK-886 147-152 peroxisome proliferator activated receptor alpha Rattus norvegicus 125-135 27646482-9 2016 However, similar findings from the sham of vehicle groups were observed if PPARalpha antagonist MK-886 was administered to rats (10, 20, 30mg/Kg, i.p.). MK-886 96-102 peroxisome proliferator activated receptor alpha Rattus norvegicus 75-84 30551401-9 2019 Meanwhile, MK886, a PPARalpha antagonist, GSK0660, a PPARbeta antagonist, and GW9662, a PPARgamma antagonist, reversed the protection of naringenin on cardiomyocytes (P < 0.05), and abrogated the up-regulation of CYP2J3-EET produced by naringenin (P < 0.05). MK-886 11-16 peroxisome proliferator activated receptor alpha Rattus norvegicus 20-29 30635472-8 2019 However, the aforementioned effects of PEA were completely or partially abolished by MK886, a selective PPARalpha antagonist. MK-886 85-90 peroxisome proliferator activated receptor alpha Rattus norvegicus 104-113 30557558-7 2019 On the other hand, in isolated CD4+ T cells from experimental autoimmune myocarditis (EAM) rats, PPARalpha agonist Fenofibrate decreased the expression of IL-17 and RORgammat, increased the expression of Foxp3, while PPARalpha antagonist MK886 reversed these effects. MK-886 238-243 peroxisome proliferator activated receptor alpha Rattus norvegicus 97-106 28236037-6 2018 However, these effects of osthole were reduced or abrogated after simultaneous addition of the specific PPARalpha antagonist MK886 or/and the PPARgamma antagonist GW9662, especially in the co-PPARalpha/gamma antagonists-treated group. MK-886 125-130 peroxisome proliferator activated receptor alpha Rattus norvegicus 104-113 23844263-4 2013 The effects of PGI2 were abrogated by MK886, a PPARalpha antagonist, but not GSK3787, a PPARdelta antagonist. MK-886 38-43 peroxisome proliferator activated receptor alpha Rattus norvegicus 47-56 27100490-5 2016 The mRNA and protein levels of CPT-Ialpha gene from HepG2 cells and hyperlipidemic rat liver are remarkably up-regulated by berberine, and this effect can be blocked by MK886, a non-competitive antagonist of PPARalpha. MK-886 169-174 peroxisome proliferator activated receptor alpha Rattus norvegicus 208-217 23889688-5 2013 These effects were abolished in the presence of the PPAR-alpha antagonist MK886. MK-886 74-79 peroxisome proliferator activated receptor alpha Rattus norvegicus 52-62 23573121-9 2013 MK886 (0.3 mu mol/L), a selective PPAR alpha antagonist, could abolish the effects of berberine and fenofibrate. MK-886 0-5 peroxisome proliferator activated receptor alpha Rattus norvegicus 35-45 18267115-8 2008 These effects of fenofibrate were abolished by PPARalpha inhibitor MK886, suggesting that fenofibrate activated through PPARalpha. MK-886 67-72 peroxisome proliferator activated receptor alpha Rattus norvegicus 47-56 21323895-6 2011 The inhibitory effect of 20-HETE on COX-2 expression was mimicked by WY14643, a PPARalpha ligand and inhibited by MK886, a PPARalpha inhibitor or by transfection of shRNA for PPARalpha. MK-886 114-119 peroxisome proliferator activated receptor alpha Rattus norvegicus 123-132 21323895-6 2011 The inhibitory effect of 20-HETE on COX-2 expression was mimicked by WY14643, a PPARalpha ligand and inhibited by MK886, a PPARalpha inhibitor or by transfection of shRNA for PPARalpha. MK-886 114-119 peroxisome proliferator activated receptor alpha Rattus norvegicus 123-132 23022336-4 2012 Both MK886 [(1-[(4-chlorophenyl)methyl]-3-1,1-dimethylethyl)thio]-(alpha,alpha-dimethyl-5-1-methylethyl)-1H-indole-2-propanoic acid (PPARalpha antagonist) and GW9662 (2-chloro-5-nitrobenzanilide) (PPARgamma antagonists) inhibited Wy14643-induced relaxations. MK-886 5-10 peroxisome proliferator activated receptor alpha Rattus norvegicus 133-142 20801430-7 2011 The ability of WY14643 and methOEA to counteract the behavioral, electrophysiological, and neurochemical effects of nicotine was reversed by the PPAR-alpha antagonist 1-[(4-Chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-a,a-dimethyl-5-(1-methylethyl)-1H-Indole-2-propanoic acid (MK886). MK-886 281-286 peroxisome proliferator activated receptor alpha Rattus norvegicus 145-155 19938896-9 2010 Last, we found that MK-886, a known inhibitor of peroxisome proliferator-activated receptor alpha (PPARalpha), increased the MEHP-induced TNF-alpha response. MK-886 20-26 peroxisome proliferator activated receptor alpha Rattus norvegicus 49-97 19938896-9 2010 Last, we found that MK-886, a known inhibitor of peroxisome proliferator-activated receptor alpha (PPARalpha), increased the MEHP-induced TNF-alpha response. MK-886 20-26 peroxisome proliferator activated receptor alpha Rattus norvegicus 99-108 20193367-11 2009 These effects of fenofibrate were abolished by PPARalpha inhibitor MK886, suggesting that fenofibrate activated through PPARalpha. MK-886 67-72 peroxisome proliferator activated receptor alpha Rattus norvegicus 47-56 20193367-11 2009 These effects of fenofibrate were abolished by PPARalpha inhibitor MK886, suggesting that fenofibrate activated through PPARalpha. MK-886 67-72 peroxisome proliferator activated receptor alpha Rattus norvegicus 120-129 19403796-2 2009 Using a passive-avoidance task in rats, we found that memory acquisition was enhanced by the FAAH inhibitor URB597 or by the PPAR-alpha agonist WY14643, and these enhancements were blocked by the PPAR-alpha antagonist MK886. MK-886 218-223 peroxisome proliferator activated receptor alpha Rattus norvegicus 125-135 19403796-2 2009 Using a passive-avoidance task in rats, we found that memory acquisition was enhanced by the FAAH inhibitor URB597 or by the PPAR-alpha agonist WY14643, and these enhancements were blocked by the PPAR-alpha antagonist MK886. MK-886 218-223 peroxisome proliferator activated receptor alpha Rattus norvegicus 196-206 18267115-8 2008 These effects of fenofibrate were abolished by PPARalpha inhibitor MK886, suggesting that fenofibrate activated through PPARalpha. MK-886 67-72 peroxisome proliferator activated receptor alpha Rattus norvegicus 120-129 12475913-4 2003 Both MK-886, an antagonist of PPARalpha, and a dominant negative form of PPARalpha transfected into INS(832/13) cells caused a significant reduction in GIPR expression in low, but not high, glucose conditions. MK-886 5-11 peroxisome proliferator activated receptor alpha Rattus norvegicus 30-39 17991720-7 2008 Treatment with MK886 inhibited expression of PPARalpha, blocking PPARalpha-regulated PDX-1 expression, and the downstream transcription events of PDX-1. MK-886 15-20 peroxisome proliferator activated receptor alpha Rattus norvegicus 45-54 17991720-7 2008 Treatment with MK886 inhibited expression of PPARalpha, blocking PPARalpha-regulated PDX-1 expression, and the downstream transcription events of PDX-1. MK-886 15-20 peroxisome proliferator activated receptor alpha Rattus norvegicus 65-74 16863991-6 2006 The PPAR-alpha antagonist MK886 abolished the beneficial effects of WY14643. MK-886 26-31 peroxisome proliferator activated receptor alpha Rattus norvegicus 4-14 11856764-5 2002 MK886, known as a noncompetitive inhibitor of PPAR(alpha), completely abolished the potentiation of sPLA(2)-IIA secretion and activity by WY14643, thus indicating that the effect of WY14643 is specifically mediated by PPAR(alpha). MK-886 0-5 peroxisome proliferator activated receptor alpha Rattus norvegicus 46-50 11856764-5 2002 MK886, known as a noncompetitive inhibitor of PPAR(alpha), completely abolished the potentiation of sPLA(2)-IIA secretion and activity by WY14643, thus indicating that the effect of WY14643 is specifically mediated by PPAR(alpha). MK-886 0-5 peroxisome proliferator activated receptor alpha Rattus norvegicus 218-222