PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20061081-7 2010 MK886 (5-LOX activating protein inhibitor) mediated the induction of apoptosis by elevation of caspase-3 and Bax/Bcl2 ratio. MK-886 0-5 BCL2 associated X, apoptosis regulator Homo sapiens 109-112 17121918-9 2006 Combined treatment with 10 micromol/L celecoxib and MK886 could prevent this activation and had additive effects on inhibiting tumor cell proliferation, inducing cell apoptosis, decreasing Bcl-2 expression, increasing Bax expression, and determining mitochondrial depolarization in comparison with treatment with either inhibitor alone. MK-886 52-57 BCL2 associated X, apoptosis regulator Homo sapiens 218-221 14675240-0 2004 Five-lipoxygenase-activating protein inhibitor MK-886 induces apoptosis in gastric cancer through upregulation of p27kip1 and bax. MK-886 47-53 BCL2 associated X, apoptosis regulator Homo sapiens 126-129 14675240-11 2004 CONCLUSION: The present results suggest that MK-886 induces apoptosis in gastric cancer cells through upregulation of p27kip1 and bax, and that MK-886 is a potentially useful drug in gastric cancer prevention and therapy. MK-886 45-51 BCL2 associated X, apoptosis regulator Homo sapiens 130-133 14675240-11 2004 CONCLUSION: The present results suggest that MK-886 induces apoptosis in gastric cancer cells through upregulation of p27kip1 and bax, and that MK-886 is a potentially useful drug in gastric cancer prevention and therapy. MK-886 144-150 BCL2 associated X, apoptosis regulator Homo sapiens 130-133