PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28359739-4	2017	Therefore, counteracting mutant huntingtin (mHtt)-induced oxidative stress and mitochondrial dysfunction appears as a new approach to treat this devastating disease.	mhtt	44-48	huntingtin	Mus musculus	32-42	
33516737-3	2021	We previously described the 23aa Htt fragment P42, that attenuated the pathological phenotypes induced by mHtt.	mhtt	106-110	huntingtin	Mus musculus	33-36	
26581643-23	2016	One of this was Hypk, a Htt-interacting chaperone protein with the ability to solubilize mHtt aggregated structures in cell lines.	mhtt	89-93	huntingtin	Mus musculus	24-27	
25057205-5	2014	The serine/threonine kinase Akt, which regulates HTT function, rescued the spindle misorientation caused by the mHTT, by serine 421 (S421) phosphorylation, in cultured cells and in mice.	mhtt	112-116	huntingtin	Mus musculus	49-52	
21542802-3	2011	To determine the extent of cell-autonomous effects of mhtt (mutant huntingtin) protein on vulnerability to excitotoxic insult in MSNs in vivo, we measured the number of degenerating neurons in response to intrastriatal injection of QA (quinolinic acid) in presymptomatic and symptomatic transgenic (D9-N171-98Q, also known as DE5) mice that express mhtt in MSNs but not in cortex.	mhtt	54-58	huntingtin	Mus musculus	67-77	
20424159-1	2010	We recently reported that the small G-protein Rhes has the properties of a SUMO-E3 ligase and mediates mutant huntingtin (mHtt) cytotoxicity.	mhtt	122-126	huntingtin	Mus musculus	110-120	
19864571-4	2009	We previously showed that V(L)12.3, an intrabody recognizing the N terminus of Htt, and Happ1, an intrabody recognizing the proline-rich domain of Htt, both reduce mHtt-induced toxicity and aggregation in cell culture and brain slice models of HD.	mhtt	164-168	huntingtin	Mus musculus	147-150	
34884469-6	2021	Here, we tested the relevance of strain background for mutant huntingtin (mHTT) toxicity on the cellular level by investigating HD pathologies in YAC128 mice in the C57BL/6 background (YAC128/BL6).	mhtt	74-78	huntingtin	Mus musculus	62-72	
32574176-1	2020	In the BACHD mouse model of Huntington"s disease (HD), deletion of the N17 domain of the Huntingtin gene (BACHDDeltaN17, Q97) has been reported to lead to nuclear accumulation of mHTT and exacerbation of motor deficits, neuroinflammation and striatal atrophy (Gu et al., 2015).	mhtt	179-183	huntingtin	Mus musculus	89-99	
29151587-7	2017	Interestingly, their effects on HTT levels are mHTT-dependent, providing a feedback mechanism in which mHTT enhances its own level thus contributing to mHTT accumulation and disease progression.	mhtt	47-51	huntingtin	Mus musculus	32-35	
29151587-7	2017	Interestingly, their effects on HTT levels are mHTT-dependent, providing a feedback mechanism in which mHTT enhances its own level thus contributing to mHTT accumulation and disease progression.	mhtt	103-107	huntingtin	Mus musculus	32-35	
29151587-7	2017	Interestingly, their effects on HTT levels are mHTT-dependent, providing a feedback mechanism in which mHTT enhances its own level thus contributing to mHTT accumulation and disease progression.	mhtt	103-107	huntingtin	Mus musculus	32-35	
33310753-5	2021	We have also shown that lowering HTT in the brains of HD mice results in correlative reduction of mHTT in the CSF, prompting the use of this measure as an exploratory marker of target engagement in clinical trials.	mhtt	98-102	huntingtin	Mus musculus	33-36	
33310753-10	2021	Overall, our data supports both passive release and active clearance of mHTT into CSF, suggesting that its treatment-induced changes may represent a combination of target engagement and preservation of neurons.SIGNIFICANCE STATEMENTChanges in cerebrospinal fluid (CSF) mutant huntingtin (mHTT) are being used as an exploratory endpoint in HTT lowering clinical trials for the treatment of Huntington disease (HD).	mhtt	72-76	huntingtin	Mus musculus	276-286