PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32508327-4 2020 OBJECTIVE: To report additional safety and exploratory efficacy data for continued open-label use of 45 mg BID pridopidine at 48 and 60 months. pridopidine 111-122 BH3 interacting domain death agonist Homo sapiens 107-110 32508327-13 2020 CONCLUSION: The 45 mg BID pridopidine dosage remained safe and tolerable over 60 months. pridopidine 26-37 BH3 interacting domain death agonist Homo sapiens 22-25 32508327-15 2020 Results are consistent with data reported from the recent Phase 2 PRIDE-HD trial showing less functional decline in the pridopidine 45 mg BID treated group at 52 weeks. pridopidine 120-131 BH3 interacting domain death agonist Homo sapiens 138-141 33164941-6 2020 RESULTS: The pridopidine 45 mg bid dosage demonstrated a beneficial effect on TFC for the entire population at week 52 of 0.87 (nominal p = 0.003). pridopidine 13-24 BH3 interacting domain death agonist Homo sapiens 31-34 33164941-9 2020 Responder analyses showed pridopidine 45 mg bid reduced the probability of TFC decline in early HD patients at Week 52 (nominal p = 0.02). pridopidine 26-37 BH3 interacting domain death agonist Homo sapiens 44-47 33164941-10 2020 CONCLUSION: Pridopidine 45 mg bid results in a nominally significant reduction in TFC decline at 52 weeks compared to placebo, particularly in patients with early-stage HD. pridopidine 12-23 BH3 interacting domain death agonist Homo sapiens 30-33