PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29783994-10	2018	In the striatum of YAC128 HD mice, pridopidine treatment initiation prior to symptomatic manifestation rescues the impaired expression of the BDNF, GR, D1R and cAMP pathways.	pridopidine	35-46	brain derived neurotrophic factor	Mus musculus	142-146	
27466197-6	2016	Pridopidine upregulated the BDNF pathway (P = 1.73E-10), and its effect on BDNF secretion was sigma 1 receptor (S1R) dependent.	pridopidine	0-11	brain derived neurotrophic factor	Mus musculus	28-32	
27466197-6	2016	Pridopidine upregulated the BDNF pathway (P = 1.73E-10), and its effect on BDNF secretion was sigma 1 receptor (S1R) dependent.	pridopidine	0-11	brain derived neurotrophic factor	Mus musculus	75-79	
27466197-9	2016	Pridopidine upregulates expression of BDNF, D1R, GR and AKT/PI3K pathways, known to promote neuronal plasticity and survival, as well as reported to demonstrate therapeutic benefit in HD animal models.	pridopidine	0-11	brain derived neurotrophic factor	Mus musculus	38-42	
27466197-10	2016	Activation of S1R, necessary for its effect on the BDNF pathway, represents a core component of the mode of action of pridopidine.	pridopidine	118-129	brain derived neurotrophic factor	Mus musculus	51-55	
26604684-8	2015	More recently, the analysis of HD models (ie, in vitro and in mice) highlighted previously unknown effects of pridopidine (increase in brain-derived neurotrophic factor, reduction in mHtt levels, and sigma-1 receptor binding and modulation).	pridopidine	110-121	brain derived neurotrophic factor	Mus musculus	135-168	
31156395-11	2019	Strikingly, we were able to restore the TTX-induced changes in YAC128 cultures by treating them with pridopidine, a drug which enhances BDNF signaling through stimulation of the sigma-1 receptor (S1R), and with the S1R agonist 3-PPP.	pridopidine	101-112	brain derived neurotrophic factor	Mus musculus	136-140	
26094900-8	2015	Coherent with protective effects, pridopidine-mediated beneficial effects in R6/2 mice were associated with an increased expression of pro-survival and neurostimulatory molecules, such as brain derived neurotrophic factor and DARPP32, and with a reduction in the size of mHtt aggregates in striatal tissues.	pridopidine	34-45	brain derived neurotrophic factor	Mus musculus	188-221	
30756361-6	2019	The behavioral recovery induced by pridopidine 0.3 mg/kg was accompanied by a significant protection of nigral dopamine cell bodies, an increased dopaminergic fiber density in the striatum, and striatal upregulation of GDNF, BDNF, and phosphorylated ERK1/2.	pridopidine	35-46	brain derived neurotrophic factor	Mus musculus	225-229