PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34666245-0 2021 Trelagliptin ameliorates IL-1beta-impaired chondrocyte function via the AMPK/SOX-9 pathway. trelagliptin 0-12 SRY-box transcription factor 9 Homo sapiens 77-82 34666245-9 2021 Moreover, we show that Trelagliptin restores IL-1beta-induced reduction of SOX-9 and that the knockdown of SOX-9 abolishes the protective effects of Trelagliptin. trelagliptin 23-35 SRY-box transcription factor 9 Homo sapiens 75-80 34666245-9 2021 Moreover, we show that Trelagliptin restores IL-1beta-induced reduction of SOX-9 and that the knockdown of SOX-9 abolishes the protective effects of Trelagliptin. trelagliptin 149-161 SRY-box transcription factor 9 Homo sapiens 107-112 34666245-10 2021 Mechanistically, we demonstrate that AMPK is required for the amelioration of Trelagliptin on SOX-9- reduction by IL-1beta. trelagliptin 78-90 SRY-box transcription factor 9 Homo sapiens 94-99