PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34666245-0 2021 Trelagliptin ameliorates IL-1beta-impaired chondrocyte function via the AMPK/SOX-9 pathway. trelagliptin 0-12 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 72-76 34666245-10 2021 Mechanistically, we demonstrate that AMPK is required for the amelioration of Trelagliptin on SOX-9- reduction by IL-1beta. trelagliptin 78-90 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 37-41 34435315-8 2021 Lastly, the AMPK pathway was observed to be significantly activated in OGD/R-challenged HAVECs by Trelagliptin treatment. trelagliptin 98-110 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 12-16 34435315-9 2021 After co-administration of the inhibitor of the AMPK pathway, the effects of Trelagliptin on mitochondrial function and metabolic alterations were significantly abolished. trelagliptin 77-89 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 48-52 34435315-10 2021 Taken together, our data indicate that Trelagliptin ameliorated OGD/R-induced mitochondrial disturbance and metabolic changes by activating the AMPK pathway. trelagliptin 39-51 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 144-148