PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26119076-5 2015 In addition, gene expression of fatty acid synthase (FAS) was significantly inhibited by treatment with epiberberine during adipogenesis. epiberberine 104-116 fatty acid synthase Homo sapiens 32-51 26119076-5 2015 In addition, gene expression of fatty acid synthase (FAS) was significantly inhibited by treatment with epiberberine during adipogenesis. epiberberine 104-116 fatty acid synthase Homo sapiens 53-56 26119076-6 2015 These results indicate that the anti-adipogenic mechanism of epiberberine is associated with inhibition of phosphorylation of Raf/MEK1/ERK1/2 and AMPKalpha/Akt, followed by downregulation of the major transcription factors of adipogenesis, such as PPAR-gamma, C/EBP-alpha, and SREBP-1, and FAS. epiberberine 61-73 fatty acid synthase Homo sapiens 290-293