PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2693891-0 1989 Induction of hepatic cytochrome P450 gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Polychlorinated Dibenzodioxins 56-91 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 21-36 2703963-6 1989 Of the cytochrome P-450 inducers, 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin, increased the biliary excretion of AA-GS (2.9- and 3.2-fold, respectively) whereas ethanol and isoniazid did not affect it, and pregnenolone-16 alpha-carbonitrile tended to decrease it (43%). Polychlorinated Dibenzodioxins 59-94 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 7-23 2834196-8 1987 This increase in enzyme activity was associated with a parallel increase in placental microsomal protein immunochemically related to cytochrome P-450 form 6 [derived from 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced rabbit lung]. Polychlorinated Dibenzodioxins 171-206 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 133-149 2834196-8 1987 This increase in enzyme activity was associated with a parallel increase in placental microsomal protein immunochemically related to cytochrome P-450 form 6 [derived from 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced rabbit lung]. Polychlorinated Dibenzodioxins 208-212 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 133-149 18595692-4 2008 In cellulo, the probe revealed the induction of cytochrome P450 activity by the carcinogen 2,3,7,8-tetrachlorodibenzo-p-dioxin, and its repression by the chemoprotectant resveratrol. Polychlorinated Dibenzodioxins 91-126 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 48-63 33015460-2 2020 TCDD is considered a carcinogen and has proinflammatory influence on animals and humans, promoting free radicals" formation, and binding with the aryl hydrocarbon receptor (AhR) leads to expression of cytochrome p-450 genes that in turn predisposes to mutations. Polychlorinated Dibenzodioxins 0-4 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 201-217 25454080-8 2015 Lastly, different CYP families were induced in RL-14 cells using 2,3,7,8-tetrachlorodibenzo-p-dioxin and fenofibrate at mRNA and protein levels. Polychlorinated Dibenzodioxins 65-100 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 18-21 25123135-0 2014 Mammalian cytochrome P450-dependent metabolism of polychlorinated dibenzo-p-dioxins and coplanar polychlorinated biphenyls. Polychlorinated Dibenzodioxins 50-83 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 10-25 25123135-3 2014 A number of human CYP isoforms belonging to the CYP1 and CYP2 families showed remarkable activities toward low-chlorinated PCDDs. Polychlorinated Dibenzodioxins 123-128 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 18-21 19324859-0 2009 Expression of cytochrome P450 (CYP) enzymes in human nonpigmented ciliary epithelial cells: induction of CYP1B1 expression by TCDD. Polychlorinated Dibenzodioxins 126-130 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 14-29 19324859-0 2009 Expression of cytochrome P450 (CYP) enzymes in human nonpigmented ciliary epithelial cells: induction of CYP1B1 expression by TCDD. Polychlorinated Dibenzodioxins 126-130 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 31-34 17850846-3 2007 Of the stress-related genes, the expressions of the aryl hydrocarbon receptor (AhR), cytochrome P450 (CYP) and p53 genes were most significantly induced by exposure to PCDDs/DFs. Polychlorinated Dibenzodioxins 168-173 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 85-100 17850846-3 2007 Of the stress-related genes, the expressions of the aryl hydrocarbon receptor (AhR), cytochrome P450 (CYP) and p53 genes were most significantly induced by exposure to PCDDs/DFs. Polychlorinated Dibenzodioxins 168-173 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 102-105 17850846-6 2007 Statistical tests revealed significant correlations between the PCDDs/DFs concentration and the AhR and CYP gene expression/cell viability/DNA damage. Polychlorinated Dibenzodioxins 64-69 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 104-107 11891538-0 2002 The environmental toxin 2,3,7,8-tetrachlorodibenzo-p-dioxin induces cytochrome P450 activity in high passage PC 3 and DU 145 human prostate cancer cell lines. Polychlorinated Dibenzodioxins 24-59 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 68-83 15596250-1 2005 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is highly toxic in experimental animals, and is known to induce cytochrome P450 (CYP) gene expression. Polychlorinated Dibenzodioxins 0-35 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 107-122 15596250-1 2005 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is highly toxic in experimental animals, and is known to induce cytochrome P450 (CYP) gene expression. Polychlorinated Dibenzodioxins 0-35 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 124-127 15596250-1 2005 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is highly toxic in experimental animals, and is known to induce cytochrome P450 (CYP) gene expression. Polychlorinated Dibenzodioxins 37-41 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 107-122 15596250-1 2005 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is highly toxic in experimental animals, and is known to induce cytochrome P450 (CYP) gene expression. Polychlorinated Dibenzodioxins 37-41 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 124-127 15596250-7 2005 However, when lymphocytes were treated in vitro with 10 nM TCDD, CYP1B1 and CYP1A1 mRNA expression was strongly induced and modified by CYP variant alleles. Polychlorinated Dibenzodioxins 59-63 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 65-68 15596250-11 2005 Genetic variation in cytochrome P450 induction may identify subjects with variable responsiveness to TCDD and potentially increased risk of disease. Polychlorinated Dibenzodioxins 101-105 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 21-36 12207498-0 2002 Metabolism of polychlorinated dibenzo-p-dioxins (PCDDs) by human cytochrome P450-dependent monooxygenase systems. Polychlorinated Dibenzodioxins 14-47 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 65-80 12207498-0 2002 Metabolism of polychlorinated dibenzo-p-dioxins (PCDDs) by human cytochrome P450-dependent monooxygenase systems. Polychlorinated Dibenzodioxins 49-54 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 65-80 12207498-1 2002 Metabolism of polychlorinated dibenzo-p-dioxins (PCDDs) by monooxygenase systems dependent on 12 forms of human cytochrome P450 (CYP) was examined with the recombinant yeast microsomes containing each of the human CYP. Polychlorinated Dibenzodioxins 14-47 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 112-127 12207498-1 2002 Metabolism of polychlorinated dibenzo-p-dioxins (PCDDs) by monooxygenase systems dependent on 12 forms of human cytochrome P450 (CYP) was examined with the recombinant yeast microsomes containing each of the human CYP. Polychlorinated Dibenzodioxins 14-47 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 129-132 12207498-1 2002 Metabolism of polychlorinated dibenzo-p-dioxins (PCDDs) by monooxygenase systems dependent on 12 forms of human cytochrome P450 (CYP) was examined with the recombinant yeast microsomes containing each of the human CYP. Polychlorinated Dibenzodioxins 14-47 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 214-217 12207498-1 2002 Metabolism of polychlorinated dibenzo-p-dioxins (PCDDs) by monooxygenase systems dependent on 12 forms of human cytochrome P450 (CYP) was examined with the recombinant yeast microsomes containing each of the human CYP. Polychlorinated Dibenzodioxins 49-54 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 112-127 12207498-1 2002 Metabolism of polychlorinated dibenzo-p-dioxins (PCDDs) by monooxygenase systems dependent on 12 forms of human cytochrome P450 (CYP) was examined with the recombinant yeast microsomes containing each of the human CYP. Polychlorinated Dibenzodioxins 49-54 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 129-132 12207498-1 2002 Metabolism of polychlorinated dibenzo-p-dioxins (PCDDs) by monooxygenase systems dependent on 12 forms of human cytochrome P450 (CYP) was examined with the recombinant yeast microsomes containing each of the human CYP. Polychlorinated Dibenzodioxins 49-54 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 214-217