PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26226543-7 2015 The structure-dependent induction of CYP1A1 and CYP1B1 gene expression in Ah-responsive MDA-MB-468 breast cancer cells by these carbazoles was similar to that observed for other dioxin-like compounds, and the magnitude of the fold induction responses for the most active halogenated carbazoles was similar to that observed for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Polychlorinated Dibenzodioxins 327-362 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 48-54 27837168-5 2017 1- and 4-HNA were less potent than 1,4-DHNA but induced maximal (TCDD-like) response for CYP1B1 (both cell lines) and CYP1A1 (Caco2 cells). Polychlorinated Dibenzodioxins 65-69 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 89-95 27358009-2 2016 The TCDD-liganded AHR massively upregulates CYP1A1, CYP1A2 and CYP1B1 in many mammalian organs. Polychlorinated Dibenzodioxins 4-8 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 63-69 26990437-8 2017 As with Cyp1b1 in wild-type mice, constitutive hCYP1B1 protein is non-detectable in liver but was induced with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Polychlorinated Dibenzodioxins 111-146 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 47-54 27535091-0 2016 Role of aryl hydrocarbon receptor polymorphisms on TCDD-mediated CYP1B1 induction and IgM suppression by human B cells. Polychlorinated Dibenzodioxins 51-55 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 65-71 27535091-4 2016 TCDD-induced Cyp1B1 and Cyp1A2 mRNA expression levels and Cyp1B1-regulated reporter gene activity, used for comparative purposes, were markedly lower in SKW cells containing the R554K SNP than in SKW-AHR(+) (control AhR) cells. Polychlorinated Dibenzodioxins 0-4 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 13-19 27535091-6 2016 Collectively, our findings show that the R554K human AhR SNP alone altered sensitivity of human B cells to TCDD-mediated induction of Cyp1B1 and Cyp1A2. Polychlorinated Dibenzodioxins 107-111 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 134-140 26226543-7 2015 The structure-dependent induction of CYP1A1 and CYP1B1 gene expression in Ah-responsive MDA-MB-468 breast cancer cells by these carbazoles was similar to that observed for other dioxin-like compounds, and the magnitude of the fold induction responses for the most active halogenated carbazoles was similar to that observed for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Polychlorinated Dibenzodioxins 364-368 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 48-54 23700305-0 2015 2,3,7,8-Tetrachlorodibenzo-p-dioxin modulates estradiol-induced aldehydic DNA lesions in human breast cancer cells through alteration of CYP1A1 and CYP1B1 expression. Polychlorinated Dibenzodioxins 0-35 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 148-154 25858487-0 2015 Aryl hydrocarbon receptor regulates CYP1B1 but not ABCB1 and ABCG2 in hCMEC/D3 human cerebral microvascular endothelial cells after TCDD exposure. Polychlorinated Dibenzodioxins 132-136 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 36-42 25858487-6 2015 Exposure to TCDD induced a concentration-dependent increase in CYP1B1 expression. Polychlorinated Dibenzodioxins 12-16 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 63-69 25858487-7 2015 We demonstrated AhR involvement in the TCDD-mediated increase in CYP1B1 expression by using small interfering RNA against AhR. Polychlorinated Dibenzodioxins 39-43 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 65-71 25858487-8 2015 Western blotting analysis also revealed an increase in CYP1B1 protein expression following TCDD exposure in hCMEC/D3. Polychlorinated Dibenzodioxins 91-95 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 55-61 25858487-10 2015 In conclusion our data indicated a differential modulation of CYP1B1 and ABCB1/ABCG2 expressions in hCMEC/D3 cells following TCDD exposure. Polychlorinated Dibenzodioxins 125-129 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 62-68 25637755-5 2015 Induction of CYP1A1 and CYP1B1 mRNA by TCDD in WT cells each exhibited bursts of activity in the initial hour which were about 3-fold greater than in LAI cells. Polychlorinated Dibenzodioxins 39-43 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 24-30 23700305-7 2015 CONCLUSIONS: TCDD pretreatment induces disparity in the disposition of E2 to reactive quinonoid metabolites and the subsequent formation of oxidative DNA lesions through alteration of CYP1A1 and CYP1B1 expression in human breast cancer cells. Polychlorinated Dibenzodioxins 13-17 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 195-201 26567990-6 2015 Nonetheless, treatment of parental as well as differentiated SH-SY5Y cells with TCDD resulted in the induction of AhR-regulated genes, CYP1A1 and CYP1B1; AhRR expression was also affected, but to a much smaller extent. Polychlorinated Dibenzodioxins 80-84 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 146-152 25327972-6 2015 Then, we observed that a 6 h exposure to 25 nM 2,3,7,8-tetrachlorodibenzo-p-dioxin, a strong AhR ligand, up-regulated CYP1A1 and CYP1B1 expression, and that this effect was AhR dependent. Polychlorinated Dibenzodioxins 47-82 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 129-135 25404385-12 2014 At 10 nM, TCDD time-dependently decreased AhR protein levels, while it significantly increased CYP1A1 and CYP1B1 mRNA levels in SKOV-3, OVCAR-3 and IOSE-385 cells, indicating activation of AhR signaling. Polychlorinated Dibenzodioxins 10-14 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 106-112 23275542-4 2013 RNAi-mediated knockdown of TiPARP in T-47D breast cancer and HuH-7 hepatoma cells increased TCDD-dependent cytochrome P450 1A1 (CYP1A1) and CYP1B1 messenger RNA (mRNA) expression levels and recruitment of AHR to both genes. Polychlorinated Dibenzodioxins 92-96 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 140-146 25110054-3 2014 Our results indicated that metformin down-regulated the expression of CYP1A1 and CYP1B1 in breast cancer cells under constitutive and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced conditions. Polychlorinated Dibenzodioxins 134-169 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 81-87 25110054-3 2014 Our results indicated that metformin down-regulated the expression of CYP1A1 and CYP1B1 in breast cancer cells under constitutive and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced conditions. Polychlorinated Dibenzodioxins 171-175 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 81-87 25123135-4 2014 In particular, human CYP1A1, CYP1A2, and CYP1B1 showed high activities toward monoCDDs, diCDDs, and triCDDs but no detectable activity toward 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-tetraCDD). Polychlorinated Dibenzodioxins 142-177 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 41-47 25123135-4 2014 In particular, human CYP1A1, CYP1A2, and CYP1B1 showed high activities toward monoCDDs, diCDDs, and triCDDs but no detectable activity toward 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-tetraCDD). Polychlorinated Dibenzodioxins 179-195 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 41-47 24299737-4 2014 Basal and TCDD-, 17beta-estradiol (E2)-, or TCDD + E2-dependent recruitment of AHR, ARNT, ERalpha, NCoA3, and RNA polymerase II to CYP1B1 as well as CYP1B1 mRNA levels were abolished in MCF7-AHR((ko)) and MDA-MB-231 AHR(ko) cells. Polychlorinated Dibenzodioxins 44-48 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 131-137 24299737-4 2014 Basal and TCDD-, 17beta-estradiol (E2)-, or TCDD + E2-dependent recruitment of AHR, ARNT, ERalpha, NCoA3, and RNA polymerase II to CYP1B1 as well as CYP1B1 mRNA levels were abolished in MCF7-AHR((ko)) and MDA-MB-231 AHR(ko) cells. Polychlorinated Dibenzodioxins 44-48 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 149-155 24299737-8 2014 Our data show that AHR and ARNT play critical roles in the basal, TCDD, and E2-induced regulation of CYP1B1 but also reveal distinct roles for both proteins in ERalpha transactivation. Polychlorinated Dibenzodioxins 66-70 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 101-107 24795504-8 2014 AhR in fibroblasts was activated by TCDD with an increased expression of cyp1a1 and cyp1b1. Polychlorinated Dibenzodioxins 36-40 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 84-90 24565903-9 2014 AhR dependent gene expression, i.e. CYP1A1 and CYP1B1 increased gradually with TCDD incubation time. Polychlorinated Dibenzodioxins 79-83 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 47-53 24565903-12 2014 Exposure of HSY cells to TCDD resulted in time-dependent induction of CYP1A1 and CYP1B1 enzymatic activity. Polychlorinated Dibenzodioxins 25-29 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 81-87 24299737-4 2014 Basal and TCDD-, 17beta-estradiol (E2)-, or TCDD + E2-dependent recruitment of AHR, ARNT, ERalpha, NCoA3, and RNA polymerase II to CYP1B1 as well as CYP1B1 mRNA levels were abolished in MCF7-AHR((ko)) and MDA-MB-231 AHR(ko) cells. Polychlorinated Dibenzodioxins 10-14 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 131-137 24299737-4 2014 Basal and TCDD-, 17beta-estradiol (E2)-, or TCDD + E2-dependent recruitment of AHR, ARNT, ERalpha, NCoA3, and RNA polymerase II to CYP1B1 as well as CYP1B1 mRNA levels were abolished in MCF7-AHR((ko)) and MDA-MB-231 AHR(ko) cells. Polychlorinated Dibenzodioxins 10-14 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 149-155 23855798-12 2013 Whereas TCDD AhR and E2 ERalpha appeared to regulate CYP1B1 separately through their binding sites, E2 ERalpha increased the TCDD responsiveness and mRNA expression of CYP1A1 in a noncanonical way. Polychlorinated Dibenzodioxins 8-12 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 57-63 20417221-10 2010 Indeed, induction by TCDD has prevailing effects in gene expression of CYP1A1, CYP1A2 and CYP1B1 in Apc(Min/+) cells, compared with Apc(+/+) ones. Polychlorinated Dibenzodioxins 21-25 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 90-96 22888330-6 2012 Treatment with TCDD induced the expression of Cyp1a1, Cyp1b1, and Ahrr in CD4(+) T-cells from AhR(+/+) mice under all culture conditions, validating the presence and activation of AhR in these cells. Polychlorinated Dibenzodioxins 15-19 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 54-60 22560882-3 2012 In a model of human non-tumorigenic prostate epithelial cells BPH-1, derived from the benign prostatic hyperplasia, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) persistently activates the AhR signaling pathway and induces expression of xenobiotic metabolizing enzymes, such as CYP1A1 or CYP1B1. Polychlorinated Dibenzodioxins 116-151 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 285-291 22187486-7 2012 Exposure of A549, HepG2 hepatic carcinoma cells, and MCF-7 breast carcinoma cells to tetrachlorodibenzo-p-dioxin induced the expression and enzymatic activity of CYP1A1 and CYP1B1, which were also suppressed by SWCNTs, suggesting that SWCNTs down-regulated both basal and induced CYP1A1 and CYP1B1 activities. Polychlorinated Dibenzodioxins 85-112 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 173-179 22187486-7 2012 Exposure of A549, HepG2 hepatic carcinoma cells, and MCF-7 breast carcinoma cells to tetrachlorodibenzo-p-dioxin induced the expression and enzymatic activity of CYP1A1 and CYP1B1, which were also suppressed by SWCNTs, suggesting that SWCNTs down-regulated both basal and induced CYP1A1 and CYP1B1 activities. Polychlorinated Dibenzodioxins 85-112 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 291-297 19919114-9 2009 Urolithins A and B were studied for their cellular uptake and inhibition of TCDD-induced CYP1B1 expression. Polychlorinated Dibenzodioxins 76-80 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 89-95 20619336-5 2010 SiAhR-transfected human hepatocytes or HepaRG cells, exposed to TCDD, were found to exhibit reduced mRNA expression of various TCDD-responsive genes, i.e. CYP1A1, CYP1A2, CYP1B1, ALDH3A1, IL17RB, FER1L3 and SLC7A5, when compared to TCDD-treated counterparts transfected with non-targeting small-interfering RNAs. Polychlorinated Dibenzodioxins 64-68 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 171-177 20619336-6 2010 AhR silencing was moreover shown to markedly counteract TCDD-mediated induction of CYP1A1/CYP1A2/CYP1B1-related ethoxyresorufin O-deethylase activity in both human hepatocytes and HepaRG cells. Polychlorinated Dibenzodioxins 56-60 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 97-103 19755661-7 2010 TCDD treatment upregulated the expression levels of AhR, CYP1A1 and CYP1B1. Polychlorinated Dibenzodioxins 0-4 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 68-74 20171976-8 2010 TCDD concentration-dependently increased CYP1A1 and CYP1B1 mRNA, protein, and enzyme activity. Polychlorinated Dibenzodioxins 0-4 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 52-58 20035023-7 2010 2,3,7,8-Tetrachlorodibenzo-p-dioxin and prochloraz induced CYP1A1 and CYP1B1 expression in both tissues. Polychlorinated Dibenzodioxins 0-35 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 70-76 19755661-6 2010 To determine whether the AhR pathway can be activated in the T24 UC cell line, we examined the expression of cytochrome P450 (CYP) 1A1 and CYP1B1, which are target genes of the AhR pathway, following exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a ligand of AhR. Polychlorinated Dibenzodioxins 212-247 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 139-145 19463925-8 2009 Moreover, 2,2",4,6"-TMS significantly suppressed EROD activity and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced CYP1A1 or CYP1B1 gene expression in human tumor cells such as HepG2 and MCF-10A. Polychlorinated Dibenzodioxins 67-102 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 128-134 19463925-8 2009 Moreover, 2,2",4,6"-TMS significantly suppressed EROD activity and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced CYP1A1 or CYP1B1 gene expression in human tumor cells such as HepG2 and MCF-10A. Polychlorinated Dibenzodioxins 104-108 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 128-134 19376845-2 2009 Resveratrol (3,4,5-trihydroxystelbine) is a naturally occurring compound that has been shown in a number of studies to inhibit the induction of CYP1A1 and CYP1B1 by dioxin (2,3,7,8-tetrachloro-dibenzo-p-dioxin), but the mechanism(s) of resveratrol inhibition is controversial. Polychlorinated Dibenzodioxins 173-209 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 155-161 19324859-0 2009 Expression of cytochrome P450 (CYP) enzymes in human nonpigmented ciliary epithelial cells: induction of CYP1B1 expression by TCDD. Polychlorinated Dibenzodioxins 126-130 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 105-111 19324859-10 2009 CYP1B1 mRNA was strongly and dose dependently induced by TCDD. Polychlorinated Dibenzodioxins 57-61 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-6 19324859-11 2009 CYP1B1 protein was detected only after TCDD treatment of the human nonpigmented ciliary epithelial cells. Polychlorinated Dibenzodioxins 39-43 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-6 19324859-12 2009 CYP1B1 promoter was activated by TCDD. Polychlorinated Dibenzodioxins 33-37 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-6 19324859-14 2009 CONCLUSIONS: TCDD potently induces CYP1B1 mRNA in human nonpigmented ciliary epithelial cells, suggesting the involvement of an AHR-mediated pathway in the regulation of ciliary CYP1B1 expression. Polychlorinated Dibenzodioxins 13-17 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 35-41 19324859-14 2009 CONCLUSIONS: TCDD potently induces CYP1B1 mRNA in human nonpigmented ciliary epithelial cells, suggesting the involvement of an AHR-mediated pathway in the regulation of ciliary CYP1B1 expression. Polychlorinated Dibenzodioxins 13-17 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 178-184 18402469-9 2008 Basal mRNA transcript levels of AKR1C1-1C3 exceed those of both basal and 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD)-induced P450 1A1 and 1B1 by up to 90-fold in A549 cells as measured by real-time reverse transcriptase polymerase chain reaction (RT-PCR) methods. Polychlorinated Dibenzodioxins 74-110 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 126-142 19038280-4 2009 In vitro experiments yielded similar results demonstrating that siRNA inhibition of Per1 significantly increases the TCDD-induced expression of Cyp1A1 and Cyp1B1 in Hepa1c1c7 cells. Polychlorinated Dibenzodioxins 117-121 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 155-161 18842620-1 2009 Cytochrome P450 (CYP) 1A1 and CYP1B1 are inducible by 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin) in the human breast cancer cell line, MCF-7. Polychlorinated Dibenzodioxins 54-89 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 30-36 18558727-0 2008 2,3,7,8-Tetrachlorodibenzo-p-dioxin modulates the induction of DNA strand breaks and poly(ADP-ribose) polymerase-1 activation by 17beta-estradiol in human breast carcinoma cells through alteration of CYP1A1 and CYP1B1 expression. Polychlorinated Dibenzodioxins 0-35 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 211-217 18434241-12 2008 Quantitative real-time reverse transcription polymerase chain reaction experiments demonstrate that induction by TCDD has prevailing effects in gene expression of CYP1A1, CYP1A2 and CYP1B1 in Apc(Min/+) cells. Polychlorinated Dibenzodioxins 113-117 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 182-188 19138946-5 2008 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induces CYP1B1 expression through the aryl hydrocarbon receptor (AhR). Polychlorinated Dibenzodioxins 0-35 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 51-57 19138946-5 2008 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induces CYP1B1 expression through the aryl hydrocarbon receptor (AhR). Polychlorinated Dibenzodioxins 37-41 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 51-57 19138946-10 2008 TCDD induced expression of CYP1B1 and its redistribution in the nucleus and cytoplasm. Polychlorinated Dibenzodioxins 0-4 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 27-33 19138946-11 2008 Concomitant treatment with resveratrol dose-dependently suppressed TCDD-induced expression of CYP1B1, mainly in the cytoplasm. Polychlorinated Dibenzodioxins 67-71 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 94-100 18402469-9 2008 Basal mRNA transcript levels of AKR1C1-1C3 exceed those of both basal and 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD)-induced P450 1A1 and 1B1 by up to 90-fold in A549 cells as measured by real-time reverse transcriptase polymerase chain reaction (RT-PCR) methods. Polychlorinated Dibenzodioxins 112-116 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 126-142 18402469-10 2008 AKR expression levels were comparable to TCDD-induced P450 1A1 and 1B1 in HBEC-KT immortalized normal human bronchial epithelial cells. Polychlorinated Dibenzodioxins 41-45 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 54-70 18089838-7 2008 TCDD-mediated inductions of various AhR targets, such as the drug metabolizing CYP1B1, the cytokine interleukin-1beta, the chemokines interleukin-8 and CCL1, the adhesion molecule beta7 integrin, and the AhR repressor, were also prevented by KN-93 in human macrophages. Polychlorinated Dibenzodioxins 0-4 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 79-85 16704738-5 2006 RESULTS: Thirty eight TCDD-inducible genes, including cytochromeP4501A1 and cytochromeP4501B1, were identified. Polychlorinated Dibenzodioxins 22-26 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 76-93 17785579-2 2007 Both CYP1A genes and CYP1B1 are transcriptionally induced by the aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor that binds 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin). Polychlorinated Dibenzodioxins 149-184 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 21-27 17785579-2 2007 Both CYP1A genes and CYP1B1 are transcriptionally induced by the aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor that binds 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin). Polychlorinated Dibenzodioxins 186-190 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 21-27 17785579-3 2007 Although the TCDD-responsive enhancers for CYP1A1 and CYP1B1 are well characterized, a similar CYP1A2 enhancer has not been identified. Polychlorinated Dibenzodioxins 13-17 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 54-60 17785579-8 2007 As expected, the CYP1A1 and CYP1B1 enhancers bind AhR in TCDD-treated cells. Polychlorinated Dibenzodioxins 57-61 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 28-34 17257637-4 2007 Our data show that normal human dermal fibroblasts (NHDFs) are responsive to TCDD, as demonstrated by induction of cytochrome p450 1B1 (CYP1B1) expression. Polychlorinated Dibenzodioxins 77-81 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 115-134 17257637-4 2007 Our data show that normal human dermal fibroblasts (NHDFs) are responsive to TCDD, as demonstrated by induction of cytochrome p450 1B1 (CYP1B1) expression. Polychlorinated Dibenzodioxins 77-81 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 136-142 16411658-4 2006 In TCDD-treated H358 cells (P4501B1 expression), the anti-BPDE hydrolysis product BP-tetrol-1 increased over 3-12 h to a constant level. Polychlorinated Dibenzodioxins 3-7 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 28-35 16527260-4 2006 2,3,7,8-Tetrachlorodibenzo-p-dioxin treatment of confluent MCF10A cells markedly induced microsomal ethoxyresorufin O-deethylase activity and CYP1A1, CYP1A2 and CYP1B1 mRNA levels, as determined by real-time RT-PCR, while treatment with 10(-4)M PhIP had little effect on these P450 transcript levels. Polychlorinated Dibenzodioxins 0-35 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 161-167 16271822-7 2006 22Rv1 cells express constitutive and TCDD-inducible CYP 1A1 and CYP 1B1 mRNA. Polychlorinated Dibenzodioxins 37-41 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 64-71 16120791-4 2005 TCDD-stimulated CYP1B1 protein and mRNA expression was significantly suppressed by TMS in a concentration-dependent manner in MCF-7, MCF-10A, and HL-60 cells. Polychlorinated Dibenzodioxins 0-4 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 16-22 16237193-8 2006 BaP- and TCDD-induced mRNA and protein levels of CYP1A1 and CYP1B1 levels were significantly elevated in CCSP-positive cell cultures. Polychlorinated Dibenzodioxins 9-13 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 60-66 16054781-7 2005 The inducibility of XRE-dependent reporter genes and CYP1B1 by TCDD was restored in these cells. Polychlorinated Dibenzodioxins 63-67 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 53-59 16120791-5 2005 Whereas TMS down-regulated TCDD-induced CYP1B1 gene expression, the levels of aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator mRNA expression were not changed by TMS treatment. Polychlorinated Dibenzodioxins 27-31 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 40-46 16120791-8 2005 Metabolic activation of TMS by CYP1B1 induced by TCDD may mediate cellular toxicity of TMS in human cancer cells because the sensitivity to TMS in MCF-7 cells treated with TCDD was more significant than in HL-60 cells treated with TCDD. Polychlorinated Dibenzodioxins 49-53 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 31-37 16120791-8 2005 Metabolic activation of TMS by CYP1B1 induced by TCDD may mediate cellular toxicity of TMS in human cancer cells because the sensitivity to TMS in MCF-7 cells treated with TCDD was more significant than in HL-60 cells treated with TCDD. Polychlorinated Dibenzodioxins 172-176 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 31-37 16120791-8 2005 Metabolic activation of TMS by CYP1B1 induced by TCDD may mediate cellular toxicity of TMS in human cancer cells because the sensitivity to TMS in MCF-7 cells treated with TCDD was more significant than in HL-60 cells treated with TCDD. Polychlorinated Dibenzodioxins 172-176 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 31-37 12376470-9 2002 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD, dioxin) induced expression of CYP1B1 in MCF-7 cells is increased by Trx-1. Polychlorinated Dibenzodioxins 0-35 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 73-79 15993909-9 2005 Genes in the conventional AH gene battery (e.g. CYP1A1, CYP1A2, CYP1B1, ALDH3A1, NQO1 and UGT1A1) remain responsive to TCDD in H/W rats despite the large deletion. Polychlorinated Dibenzodioxins 119-123 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 64-70 15596250-0 2005 CYP1A1 and CYP1B1 genotypes, haplotypes, and TCDD-induced gene expression in subjects from Seveso, Italy. Polychlorinated Dibenzodioxins 45-49 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 11-17 15596250-7 2005 However, when lymphocytes were treated in vitro with 10 nM TCDD, CYP1B1 and CYP1A1 mRNA expression was strongly induced and modified by CYP variant alleles. Polychlorinated Dibenzodioxins 59-63 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 65-71 15142886-6 2004 Our data suggest that CYP1A1- and CYP1B1-catalyzed catechol estrogen formation might play a key role in TCDD-induced oxidative damage, and resveratrol can act as a potential chemopreventive against dioxin-induced human mammary carcinogenesis by blocking the metabolic formation of the catechol estrogens and scavenging the ROS generated during their redox cycling. Polychlorinated Dibenzodioxins 104-108 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 34-40 14962508-8 2004 Meanwhile, because TCDD- and PCB126-enhanced CYP1A1 and CYP1B1 expressions were significantly reduced by the AhR antagonist and CYP1 inhibitor alpha-naphthoflavone (ANF), this indicated that the effects of TCDD and PCB126 were AhR and cytochrome p450 1 dependent. Polychlorinated Dibenzodioxins 19-23 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 56-62 14962508-8 2004 Meanwhile, because TCDD- and PCB126-enhanced CYP1A1 and CYP1B1 expressions were significantly reduced by the AhR antagonist and CYP1 inhibitor alpha-naphthoflavone (ANF), this indicated that the effects of TCDD and PCB126 were AhR and cytochrome p450 1 dependent. Polychlorinated Dibenzodioxins 206-210 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 56-62 14594946-2 2004 We found that p38 MAP kinase inhibitors (SB203580 and SB202190; 40 microm each; pyridinyl imidazole compounds) suppressed CYP1A1-mRNA induction by TCDD (2 nm) in mouse hepatoma Hepa-1 cells and in human hepatoma HepG2 cells, and also suppressed CYP1B1-mRNA induction by TCDD (2 nm) in human breast adenocarcinoma MCF7 cells. Polychlorinated Dibenzodioxins 147-151 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 245-251 12970067-4 2003 Short-term exposure to 1 nM E2 elevated the ratio of the 4- to 2-hydroxylation pathways of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced E2 metabolism and the ratio of the induced CYP1B1 to CYP1A1 mRNA levels, as determined by real-time PCR. Polychlorinated Dibenzodioxins 128-132 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 185-191 12970067-5 2003 Cells maintained long-term (9-12 months) in low-E2 medium progressively lost Ah responsiveness, as indicated by diminished rates of TCDD-induced E2 metabolism and ethoxyresorufin O-deethylase activity, and the reduced expression of the CYP1A1 and CYP1B1 mRNAs and proteins levels. Polychlorinated Dibenzodioxins 132-136 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 247-253 12927368-8 2003 Interestingly, pretreatment with TSA and AzaC increased the levels of CYP1A1, CYP1A2, and CYP1B1 induced by TCDD in HeLa cells. Polychlorinated Dibenzodioxins 108-112 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 90-96 12801909-1 2003 Cytochrome P450 (CYP) 1B1 is known to be induced by polycyclic aromatic hydrocarbons including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Polychlorinated Dibenzodioxins 95-130 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-25 12801909-1 2003 Cytochrome P450 (CYP) 1B1 is known to be induced by polycyclic aromatic hydrocarbons including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Polychlorinated Dibenzodioxins 132-136 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-25 12801909-2 2003 The constitutive and TCDD-inducible transcriptional expression of human CYP1B1 is known to be cell-specific. Polychlorinated Dibenzodioxins 21-25 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 72-78 12376470-14 2002 The results suggest that Trx-1 is involved in the constitutive expression of CYP1B1 and is required for the induction of CYP1B1 and CYP1A1 by TCDD in human MCF-7 breast cancer cells. Polychlorinated Dibenzodioxins 142-146 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 121-127 16115918-8 2005 In prostate cancer cells, CYP1B1 mRNA was induced by 2,3,7,8-tetrachlorodigenzo-p-dioxin (TCDD) and/or demethylation agent (5-aza-2-deoxycytidine). Polychlorinated Dibenzodioxins 90-94 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 26-32 15953582-0 2005 2,3,7,8-tetrachlorodibenzo-p-dioxin induces CYP1B1 expression in human luteinized granulosa cells. Polychlorinated Dibenzodioxins 0-35 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 44-50 15953582-3 2005 Exposure to 10 nM TCDD for 24 h induced a significant increase in CYP1B1, while few other genes responded. Polychlorinated Dibenzodioxins 18-22 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 66-72 15837795-5 2005 17Beta-estradiol repressed TCDD-activated Cyp1a1 and Cyp1b1 gene transcription in MCF-7 cells in the presence of cycloheximide, as determined by reverse transcription/real-time PCR. Polychlorinated Dibenzodioxins 27-31 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 53-59 15142886-0 2004 Resveratrol inhibits TCDD-induced expression of CYP1A1 and CYP1B1 and catechol estrogen-mediated oxidative DNA damage in cultured human mammary epithelial cells. Polychlorinated Dibenzodioxins 21-25 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 59-65 15142886-2 2004 In our present study, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), when treated with the cultured human mammary epithelial (MCF-10A) cells, induced the expression of cytochrome P450 1A1 (CYP1A1) and 1B1 (CYP1B1) that are responsible for the oxidation of 17beta-estradiol to produce catechol estrogens. Polychlorinated Dibenzodioxins 22-57 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 203-209 15142886-2 2004 In our present study, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), when treated with the cultured human mammary epithelial (MCF-10A) cells, induced the expression of cytochrome P450 1A1 (CYP1A1) and 1B1 (CYP1B1) that are responsible for the oxidation of 17beta-estradiol to produce catechol estrogens. Polychlorinated Dibenzodioxins 59-63 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 203-209 15157572-12 2004 Interestingly, Both E2 and ZEA could promote basal and TCDD-induced CYP1B1 activity but with no effect on CYP1B1 mRNA expression. Polychlorinated Dibenzodioxins 55-59 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 68-74 15157572-13 2004 These results suggest that the effect of ZEA on the TCDD-induced CYP1A1 activity and gene expression involved the estrogen receptor pathway and that the increase in the CYP1B1/CYP1A1 ratio underlying the basal or TCDD-treated condition might constitute one of the mechanisms underlying the synergic carcinogenic action of these compounds. Polychlorinated Dibenzodioxins 213-217 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 169-175 12927368-1 2003 Human CYP1A1, CYP1A2, and CYP1B1 mRNAs were constitutively expressed in MCF-7 (human breast carcinoma) cells and were extensively (6-12-fold) induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Polychlorinated Dibenzodioxins 153-188 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 26-32 12927368-1 2003 Human CYP1A1, CYP1A2, and CYP1B1 mRNAs were constitutively expressed in MCF-7 (human breast carcinoma) cells and were extensively (6-12-fold) induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Polychlorinated Dibenzodioxins 190-194 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 26-32 12927368-2 2003 In contrast, in HeLa (human cervical adenocarcinoma) cells, CYP1A1 and CYP1B1 were induced by TCDD by up to 2-3-fold but CYP1A2 was not detected even when the cells were treated with TCDD. Polychlorinated Dibenzodioxins 94-98 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 71-77 12927368-2 2003 In contrast, in HeLa (human cervical adenocarcinoma) cells, CYP1A1 and CYP1B1 were induced by TCDD by up to 2-3-fold but CYP1A2 was not detected even when the cells were treated with TCDD. Polychlorinated Dibenzodioxins 183-187 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 71-77 12376470-9 2002 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD, dioxin) induced expression of CYP1B1 in MCF-7 cells is increased by Trx-1. Polychlorinated Dibenzodioxins 37-41 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 73-79 12376470-11 2002 The redox inactive mutant Trx-1 completely blocks the induction of both CYP1B1 and CYP1A1 by TCDD. Polychlorinated Dibenzodioxins 93-97 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 72-78 11728381-0 2001 Suppression of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated CYP1A1 and CYP1B1 induction by 12-O-tetradecanoylphorbol-13-acetate: role of transforming growth factor beta and mitogen-activated protein kinases. Polychlorinated Dibenzodioxins 15-50 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 78-84 12213569-2 2002 Most, if not all, the biological effects of TCDD are mediated by the activation of AHR, which is a ligand-activated transcription factor required for ligand-induced expression of several detoxification genes, including those encoding for cytochrome P450 enzymes CYP1A1, CYP1A2, and CYP1B1. Polychlorinated Dibenzodioxins 44-48 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 282-288 12097275-5 2002 Both DMBA and TCDD caused a dramatic increase in the amount of CYP1A1 and CYP1B1 mRNA, the two major isoforms involved in carcinogen activation in these cells. Polychlorinated Dibenzodioxins 14-18 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 74-80 11891538-1 2002 The study was conducted to investigate whether 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces cytochrome P450 (CYP) 1A1 and CYP1B1 via the aryl hydrocarbon receptor (AhR) in the hormone-independent human prostate cancer cell lines PC 3 and DU 145. Polychlorinated Dibenzodioxins 47-82 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 128-134 11891538-1 2002 The study was conducted to investigate whether 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces cytochrome P450 (CYP) 1A1 and CYP1B1 via the aryl hydrocarbon receptor (AhR) in the hormone-independent human prostate cancer cell lines PC 3 and DU 145. Polychlorinated Dibenzodioxins 84-88 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 128-134 11891538-4 2002 Besides stimulation of EROD activity, induction of the expression of CYP1A1 and, to a lesser extend, of CYP1B1 by TCDD was also demonstrated by RT-PCR and Western blotting. Polychlorinated Dibenzodioxins 114-118 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 104-110 11728381-0 2001 Suppression of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated CYP1A1 and CYP1B1 induction by 12-O-tetradecanoylphorbol-13-acetate: role of transforming growth factor beta and mitogen-activated protein kinases. Polychlorinated Dibenzodioxins 52-56 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 78-84 11728381-3 2001 Exposure of the immortalized human breast epithelial cell line MCF10A-Neo to TPA at the time of, or up to 12 hr prior to, the addition of TCDD strongly suppressed the transcriptional activation of CYP1A1 and CYP1B1 (IC(50) approximately 0.5 nM). Polychlorinated Dibenzodioxins 138-142 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 208-214 11452142-3 2001 In a parallel, companion study using this model, TCDD exposure was shown to induce CYP1A1 mRNA, CYP1B1 mRNA, EROD (7-ethoxyresorufin-O-deethylase) activity, and CYP1B1 protein in human endometrial explants. Polychlorinated Dibenzodioxins 49-53 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 96-102 11452143-5 2001 The expression of CYP1A1 and CYP1B1 mRNA was greatest with 10 nM TCDD and increased up to 72 h after initial exposure. Polychlorinated Dibenzodioxins 65-69 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 29-35 11452143-6 2001 EROD activity increased up to 120 h. Explants from a secretory phase biopsy became reorganized in culture and formed a new epithelial membrane, while maintaining basic endometrial morphology and viability for up to 120 h. At 24 h, TCDD significantly increased CYP1A1 and CYP1B1 mRNA, and at 72 h, TCDD significantly increased EROD activity and CYP1B1 protein compared to explants cultured without TCDD for similar times. Polychlorinated Dibenzodioxins 231-235 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 271-277 11452143-6 2001 EROD activity increased up to 120 h. Explants from a secretory phase biopsy became reorganized in culture and formed a new epithelial membrane, while maintaining basic endometrial morphology and viability for up to 120 h. At 24 h, TCDD significantly increased CYP1A1 and CYP1B1 mRNA, and at 72 h, TCDD significantly increased EROD activity and CYP1B1 protein compared to explants cultured without TCDD for similar times. Polychlorinated Dibenzodioxins 231-235 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 344-350 11452143-8 2001 In explants cultured with and without TCDD exposure, CYP1B1 protein was localized in the cytoplasm of the new surface epithelial membrane and glands closest to the surface. Polychlorinated Dibenzodioxins 38-42 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 53-59 11452142-3 2001 In a parallel, companion study using this model, TCDD exposure was shown to induce CYP1A1 mRNA, CYP1B1 mRNA, EROD (7-ethoxyresorufin-O-deethylase) activity, and CYP1B1 protein in human endometrial explants. Polychlorinated Dibenzodioxins 49-53 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 161-167 11452143-0 2001 Effect of TCDD exposure on CYP1A1 and CYP1B1 expression in explant cultures of human endometrium. Polychlorinated Dibenzodioxins 10-14 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 38-44 11452143-2 2001 The present study characterizes a human endometrial explant culture model for studying the direct effects of TCDD exposure by assessing the expression of CYP1A1 and CYP1B1 mRNA (Northern blotting), protein (Western blotting), and activity (7-ethoxyresorufin-O-deethylase; EROD) in explants cultured with and without TCDD. Polychlorinated Dibenzodioxins 109-113 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 165-171 11368557-9 2001 Rates of equilenin metabolism were markedly elevated in cultures exposed to the Ah-receptor agonists, 2,3,7,8-tetrachlorodibenzo-p-dioxin and 3,4,4",5-tetrachlorobiphenyl, implicating the activities of P450s 1A1 and 1B1 in the metabolism. Polychlorinated Dibenzodioxins 102-137 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 202-219 11281733-6 2000 Expression of the CYP1B1 and PAI-2 genes was induced by TCDD in MCF-7 and RL95-2, but not in LNCaP, cells. Polychlorinated Dibenzodioxins 56-60 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 18-24 11162886-1 2000 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induced erbB2 and erbB3 in estrogen receptor (ER) positive T47D (T47D+) cells, but substantially slower than the direct induction of CYP1A1 or CYP1B1. Polychlorinated Dibenzodioxins 37-41 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 186-192 10696073-6 2000 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced CYP1A1 and CYP1B1 mRNAs 56-fold and 2.5-fold, respectively. Polychlorinated Dibenzodioxins 0-35 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 62-68 10702233-2 2000 The cytochrome P450 1B1 gene (CYP1B1) is expressed constitutively and is inducible by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the human breast adenocarcinoma cell line MCF-7 but not in the human hepatoma cell line HepG2. Polychlorinated Dibenzodioxins 86-121 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 4-23 10702233-2 2000 The cytochrome P450 1B1 gene (CYP1B1) is expressed constitutively and is inducible by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the human breast adenocarcinoma cell line MCF-7 but not in the human hepatoma cell line HepG2. Polychlorinated Dibenzodioxins 86-121 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 30-36 10702233-2 2000 The cytochrome P450 1B1 gene (CYP1B1) is expressed constitutively and is inducible by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the human breast adenocarcinoma cell line MCF-7 but not in the human hepatoma cell line HepG2. Polychlorinated Dibenzodioxins 123-127 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 4-23 10702233-2 2000 The cytochrome P450 1B1 gene (CYP1B1) is expressed constitutively and is inducible by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the human breast adenocarcinoma cell line MCF-7 but not in the human hepatoma cell line HepG2. Polychlorinated Dibenzodioxins 123-127 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 30-36 10696073-6 2000 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced CYP1A1 and CYP1B1 mRNAs 56-fold and 2.5-fold, respectively. Polychlorinated Dibenzodioxins 37-41 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 62-68 10696073-10 2000 Protein phosphatase inhibitors okadaic acid and calyculin A enhanced TCDD-induction of CYP1B1 slightly, but had negligible effects on CYP1A1 induction. Polychlorinated Dibenzodioxins 69-73 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 87-93 10415108-2 1999 RL95-2 cells were highly responsive to TCDD in terms of cytochrome P4501A1 (CYP1A1), cytochrome P4501B1 (CYP1B1), and plasminogen activator inhibitor-2 (PAI-2), whereas KLE cells showed little stimulatory effects only at high doses. Polychlorinated Dibenzodioxins 39-43 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 85-103 10568693-5 1999 A dose-dependent increase in concentration of TCDD was accompanied by a dose-dependent increase in CYP1A1, CYP1A2, and CYP1B1 mRNA expression and associated enzymes in all liver-cell populations. Polychlorinated Dibenzodioxins 46-50 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 119-125 10568693-8 1999 Furthermore, centrilobular hepatocytes showed an elevated concentration of induced CYP1A2 and CYP1B1 mRNA as compared to periportal hepatocytes within the 0.01- and 0.3-microg TCDD/kg-treatment groups. Polychlorinated Dibenzodioxins 176-180 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 94-100 10415108-2 1999 RL95-2 cells were highly responsive to TCDD in terms of cytochrome P4501A1 (CYP1A1), cytochrome P4501B1 (CYP1B1), and plasminogen activator inhibitor-2 (PAI-2), whereas KLE cells showed little stimulatory effects only at high doses. Polychlorinated Dibenzodioxins 39-43 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 105-111 9783729-7 1998 CYP1A1 and CYP1B1, additional CYP1 enzymes regulated by the aryl hydrocarbon receptor (AHR), also were inducible by TCDD and MC in LS180 cells; their concentration-dependent induction was highly correlated with induction of CYP1A2 at mRNA, protein, and catalytic levels. Polychlorinated Dibenzodioxins 116-120 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 11-17 10357772-11 1999 TCDD-induced MDA+ cells demonstrated CYP1A1 activity, whereas TCDD-induced MDA- cells displayed CYP1B1 activity. Polychlorinated Dibenzodioxins 62-66 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 96-102 10067811-0 1999 Quantitative analysis of constitutive and 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced cytochrome P450 1B1 expression in human lymphocytes. Polychlorinated Dibenzodioxins 42-77 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 86-105 10067811-6 1999 In vitro treatment of mitogen-stimulated lymphocytes with TCDD for 1-5 days of culture resulted in a peak induction of CYP1B1 after 3 days. Polychlorinated Dibenzodioxins 58-62 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 119-125 10067811-7 1999 The induction of CYP1B1 RNA levels after 3 days of culture was dose-dependent, exhibited a maximum response above 10 nM TCDD, and varied greatly among different individuals. Polychlorinated Dibenzodioxins 120-124 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 17-23 10067811-9 1999 These observations indicate that CYP1B1 exhibits variable constitutive expression and is inducible in vitro by TCDD in human lymphocytes and that the magnitude of induction varies within the population. Polychlorinated Dibenzodioxins 111-115 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 33-39 10357772-3 1999 In all lines, CYP1B1 was expressed constitutively and was induced by 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD), whereas CYP1A1 was expressed only following induction. Polychlorinated Dibenzodioxins 69-105 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 14-20 10357772-3 1999 In all lines, CYP1B1 was expressed constitutively and was induced by 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD), whereas CYP1A1 was expressed only following induction. Polychlorinated Dibenzodioxins 107-111 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 14-20 9498279-6 1998 In MDA-MB-157, MDA-MB-231 and MDA-MB-436 cells, which did not express detectable ER alpha mRNA and generally displayed fibroblastic or mesenchymal rather than epithelial morphology, CYP1B1 induction was favored, and the rate of E2 4-hydroxylation exceeded that of 2-hydroxylation in TCDD-treated cells. Polychlorinated Dibenzodioxins 283-287 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 182-188 9622076-3 1998 CYP1B1 expression was substantially induced by exposure of the cells to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) to levels ranging from 2.3 to 16.6 pmol/mg among the seven donors. Polychlorinated Dibenzodioxins 72-107 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-6 9622076-3 1998 CYP1B1 expression was substantially induced by exposure of the cells to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) to levels ranging from 2.3 to 16.6 pmol/mg among the seven donors. Polychlorinated Dibenzodioxins 109-113 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-6 9622076-6 1998 Northern and reverse transcriptase PCR analyses corroborate the donor-dependent differences in protein expression, whereby CYP1B1 mRNA (5.2 kb) was constitutively expressed and was highly induced by TCDD (33-fold). Polychlorinated Dibenzodioxins 199-203 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 123-129 9706865-6 1998 In MCF-7 cells treated with TPA prior to treatment with TCDD, the AhR mRNA level was elevated, the ERalpha mRNA level remained suppressed, and the ratio of CYP1B1 to CYP1A1 mRNA was increased compared with treatment with TCDD alone. Polychlorinated Dibenzodioxins 221-225 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 156-162 9525272-1 1998 Knowledge of the response of cytochrome P450 1B1 (CYP1B1) to exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in both humans and rodents is limited. Polychlorinated Dibenzodioxins 73-108 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 29-48 9525272-1 1998 Knowledge of the response of cytochrome P450 1B1 (CYP1B1) to exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in both humans and rodents is limited. Polychlorinated Dibenzodioxins 73-108 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 50-56 9525272-1 1998 Knowledge of the response of cytochrome P450 1B1 (CYP1B1) to exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in both humans and rodents is limited. Polychlorinated Dibenzodioxins 110-114 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 29-48 9525272-1 1998 Knowledge of the response of cytochrome P450 1B1 (CYP1B1) to exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in both humans and rodents is limited. Polychlorinated Dibenzodioxins 110-114 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 50-56 8759031-7 1996 BaP and TCDD also induced expression of the CYP1B1 protein and the pattern of induction was comparable to that observed for CYP1A1. Polychlorinated Dibenzodioxins 8-12 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 44-50 9405238-2 1997 Here, we describe a dose-dependent inhibition of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced cytochrome P450 (CYP) 1A1, CYP1B1 and NADPH-quinone-oxidoreductase (NMO-1) mRNA expression as well as TCDD-induced 7-ethoxyresorufin-O-deethylase (EROD) activity in MDA-MB 231 cells. Polychlorinated Dibenzodioxins 49-84 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 127-133 9405238-2 1997 Here, we describe a dose-dependent inhibition of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced cytochrome P450 (CYP) 1A1, CYP1B1 and NADPH-quinone-oxidoreductase (NMO-1) mRNA expression as well as TCDD-induced 7-ethoxyresorufin-O-deethylase (EROD) activity in MDA-MB 231 cells. Polychlorinated Dibenzodioxins 86-90 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 127-133 9299508-3 1997 Northern blot analysis showed that TCDD significantly increased the steady state mRNA level of CYP1A1 and CYP1B1 which was maximal at 1 nM. Polychlorinated Dibenzodioxins 35-39 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 106-112 9145908-3 1997 In the present study, we report that not only TCDD-induced expression of CYP1A1 but also basal mRNA expression of CYP1A1, CYP1B1, and aryl hydrocarbon receptor (AHR) was down-regulated by TGF-beta1 in cells not treated with TCDD. Polychlorinated Dibenzodioxins 46-50 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 122-128 9145908-3 1997 In the present study, we report that not only TCDD-induced expression of CYP1A1 but also basal mRNA expression of CYP1A1, CYP1B1, and aryl hydrocarbon receptor (AHR) was down-regulated by TGF-beta1 in cells not treated with TCDD. Polychlorinated Dibenzodioxins 224-228 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 122-128 9145908-5 1997 Furthermore, TCDD-induced expression of CYP1B1 and NMO-1 was inhibited, and the IC50 values of 5-10 pM TGF-beta1 were in the same range as observed for inhibition of CYP1A1 and AHR mRNA expression. Polychlorinated Dibenzodioxins 13-17 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 40-46 9145908-8 1997 The treatment of cells with cycloheximide led to a superinduction of TCDD-induced CYP1A1 and CYP1B1 mRNA expression and abolished the inhibitory effect of TGF-beta1 on basal as well as TCDD-induced CYP1 and AHR mRNA expression. Polychlorinated Dibenzodioxins 69-73 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 93-99 9054634-8 1997 Inducibility of CYP1B1 in cells in culture by the Ah receptor ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin was studied in primary fibroblasts and chorion carcinoma cell line JEG-3 having different CYP1A1 induction properties. Polychlorinated Dibenzodioxins 69-104 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 16-22 9393958-10 1997 The EC50 for induction of the CYP1B1 mRNA was 1.5 nM TCDD; EC50s for the stimulation of 2- and 4-MeOE2 formation were 0.68 and 1.1 nM TCDD. Polychlorinated Dibenzodioxins 53-57 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 30-36 9102211-1 1997 In this report, we present a characterization of the cell-specific expression of two human cytochrome P450 genes, CYP1A1 and CYP1B1, by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Polychlorinated Dibenzodioxins 136-171 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 125-131 9102211-1 1997 In this report, we present a characterization of the cell-specific expression of two human cytochrome P450 genes, CYP1A1 and CYP1B1, by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Polychlorinated Dibenzodioxins 173-177 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 125-131 8910454-11 1996 Deletion analysis of chloramphenicol acetyltransferase reporter gene constructs containing 5" CYP1B1 genomic fragments indicates that a region from -1022 to -835 containing three of the nine core binding motifs contributes to the TCDD-inducible expression of CYP1B1. Polychlorinated Dibenzodioxins 230-234 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 94-100 8910454-11 1996 Deletion analysis of chloramphenicol acetyltransferase reporter gene constructs containing 5" CYP1B1 genomic fragments indicates that a region from -1022 to -835 containing three of the nine core binding motifs contributes to the TCDD-inducible expression of CYP1B1. Polychlorinated Dibenzodioxins 230-234 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 259-265 8759031-9 1996 These results demonstrate that CYP1A1 and CYP1B1-related activities are induced in GMCs by BaP and TCDD and this induction is associated with metabolism of BaP to reactive intermediates that bind covalently to DNA. Polychlorinated Dibenzodioxins 99-103 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 42-48 8674051-7 1996 P450 1B1 is expressed constitutively in extrahepatic organs, including fetal tissue samples, and is highly inducible in various organs by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds in experimental animal models. Polychlorinated Dibenzodioxins 138-173 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-8 7788849-5 1995 We cloned the 5.0 kb rat homolog of CYP1B1 from a TCDD-treated rat liver cDNA library and showed that the rat and human CYP1B1 predicted amino acid sequences are 80% identical. Polychlorinated Dibenzodioxins 50-54 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 120-126 7646066-5 1995 Transcripts of CYP1B1 were detected in both cell lines and mRNA content was enhanced 8- and 30-fold in MCF-7 and MDA-MB 231 cells treated with 1 nM TCDD, respectively. Polychlorinated Dibenzodioxins 148-152 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 15-21 7597708-2 1995 Genes altered by TCDD at the transcriptional level in the transformed human keratinocyte cell line SCC-12F include cytochrome P4501A1 (CYP1A1), CYP1B1, transforming growth factor-beta 2, and plasminogen activator inhibitor-2 (PAI-2). Polychlorinated Dibenzodioxins 17-21 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 144-150 8167904-4 1993 Serum-free cells were also similar to their serum-supplemented counterparts with respect to the expression of cathepsin B activity and the induction of aryl hydrocarbon hydroxylase by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Polychlorinated Dibenzodioxins 184-219 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 152-180 7826886-8 1994 Northern blots of RNA isolated from untreated and TCDD-treated cells, when probed with the human CYP1B1 cDNA, showed induction of a 5.2 kb RNA in MCF-7 cells but not in HepG2 cells in response to treatment with TCDD. Polychlorinated Dibenzodioxins 50-54 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 97-103 7826886-8 1994 Northern blots of RNA isolated from untreated and TCDD-treated cells, when probed with the human CYP1B1 cDNA, showed induction of a 5.2 kb RNA in MCF-7 cells but not in HepG2 cells in response to treatment with TCDD. Polychlorinated Dibenzodioxins 211-215 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 97-103 8175734-7 1994 Northern blot analysis of RNA isolated from primary cultures of normal human epidermal keratinocytes showed approximately 100-fold increased levels of the CYP1B1 mRNA after treatment with 10 nM TCDD for 24 h. Low levels of constitutive CYP1B1 mRNA were detected in 15 different human tissue samples. Polychlorinated Dibenzodioxins 194-198 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 155-161 8175734-7 1994 Northern blot analysis of RNA isolated from primary cultures of normal human epidermal keratinocytes showed approximately 100-fold increased levels of the CYP1B1 mRNA after treatment with 10 nM TCDD for 24 h. Low levels of constitutive CYP1B1 mRNA were detected in 15 different human tissue samples. Polychlorinated Dibenzodioxins 194-198 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 236-242 8175734-8 1994 These results indicate that CYP1B1 is expressed in many normal human tissues and advance our understanding of the complexity of a gene family of cytochromes P450 whose expression is altered by TCDD. Polychlorinated Dibenzodioxins 193-197 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 28-34 31268702-6 2019 Among the selected TCDD responsive (CYP1A1, CYP1A2, AHR, CYP1B1, and TIPARP) genes, a nonsignificant increasing trend of the CYP1A1 expression was observed from 0.2 to 10 pg/mL of TCDD concentration through milk fat. Polychlorinated Dibenzodioxins 19-23 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 57-63 6421503-9 1984 TCDD caused an increase in AHH and ODC activities when the cells were incubated in either LHC-0 or LHC-4 medium. Polychlorinated Dibenzodioxins 0-4 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 27-30 7385237-0 1980 Dependence of the porphyrogenic effect of 2,3,7,8-tetrachlorodibenzo(p)dioxin upon inheritance of aryl hydrocarbon hydroxylase responsiveness. Polychlorinated Dibenzodioxins 42-77 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 98-126 4549995-0 1974 Aryl hydrocarbon hydroxylase induction in human lymphocyte cultures by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Polychlorinated Dibenzodioxins 71-106 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-28 8346970-3 1993 The concentration data were multiplied by potency factors derived from aryl hydrocarbon hydroxylase (AHH) induction to give 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) equivalents. Polychlorinated Dibenzodioxins 124-159 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 101-104 8346970-3 1993 The concentration data were multiplied by potency factors derived from aryl hydrocarbon hydroxylase (AHH) induction to give 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) equivalents. Polychlorinated Dibenzodioxins 161-165 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 71-99 8346970-3 1993 The concentration data were multiplied by potency factors derived from aryl hydrocarbon hydroxylase (AHH) induction to give 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) equivalents. Polychlorinated Dibenzodioxins 161-165 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 101-104 34698116-5 2021 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) significantly increased the expression of CYP1A1, CYP1B1 and AHRR in ARPE-19 cells, whereas FLII or MLL1 depletion significantly reduced the expression of these genes induced by TCDD. Polychlorinated Dibenzodioxins 0-35 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 93-99 34698116-5 2021 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) significantly increased the expression of CYP1A1, CYP1B1 and AHRR in ARPE-19 cells, whereas FLII or MLL1 depletion significantly reduced the expression of these genes induced by TCDD. Polychlorinated Dibenzodioxins 37-41 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 93-99 34698116-5 2021 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) significantly increased the expression of CYP1A1, CYP1B1 and AHRR in ARPE-19 cells, whereas FLII or MLL1 depletion significantly reduced the expression of these genes induced by TCDD. Polychlorinated Dibenzodioxins 221-225 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 93-99 2897254-4 1988 The concentration dependence on TCDD for induction of aryl hydrocarbon hydroxylase was nearly identical to that for its suppression of transglutaminase induction, with half-maximal effects observed at approximately 20 pM in each instance. Polychlorinated Dibenzodioxins 32-36 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 54-82 136041-4 1976 Among the chlorinated azoxy and azobenzenes, the potency of a congener to induce aryl hydrocarbon hydroxylase activity correlates with its binding affinity for the hepatic cytosol specific binding sites and its capacity to induce acne; this relation between structure and activity parallels that observed for the chlorinated dibenzo-p-dioxins and dibenzofurans. Polychlorinated Dibenzodioxins 313-342 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 81-109 4851117-0 1974 Comparison of 2,3,7,8-tetrachlorodibenzo-p-dioxin, a potent inducer of aryl hydrocarbon hydroxylase, with 3-methylcholanthrene. Polychlorinated Dibenzodioxins 14-49 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 71-99 4762634-0 1973 Chlorinated dibenzo-p-dioxins: potent inducers of delta-aminolevulinic acid synthetase and aryl hydrocarbon hydroxylase. Polychlorinated Dibenzodioxins 0-29 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 91-119 31268702-6 2019 Among the selected TCDD responsive (CYP1A1, CYP1A2, AHR, CYP1B1, and TIPARP) genes, a nonsignificant increasing trend of the CYP1A1 expression was observed from 0.2 to 10 pg/mL of TCDD concentration through milk fat. Polychlorinated Dibenzodioxins 180-184 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 57-63 32002969-8 2018 Treatment of HUVECs with TCDD (AhR inducer) resulted in a significant induction of AHR target genes CYP1A1, CYP1B1 and NQO1. Polychlorinated Dibenzodioxins 25-29 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 108-114 30092417-9 2018 Treatment of HUVECs with TCDD (AhR inducer) resulted in a significant induction of AHR target genes CYP1A1, CYP1B1 and NQO1. Polychlorinated Dibenzodioxins 25-29 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 108-114 30092417-12 2018 Western blot analysis confirmed CYP1B1 induction in TCDD-treated HUVECs, but not in the simvastatin group. Polychlorinated Dibenzodioxins 52-56 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 32-38 30092417-13 2018 Moreover, HUVEC exposure to TCDD resulted in induction of CYP1A1/CYP1B1 enzymatic activity. Polychlorinated Dibenzodioxins 28-32 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 65-71 32002969-11 2018 Western blot analysis confirmed CYP1B1 induction in TCDD-treated HUVECs, but not in the simvastatin group. Polychlorinated Dibenzodioxins 52-56 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 32-38 32002969-12 2018 Moreover, HUVEC exposure to TCDD resulted in induction of CYP1A1/CYP1B1 enzymatic activity. Polychlorinated Dibenzodioxins 28-32 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 65-71 29541735-9 2018 In addition, QA activated the gene expression of aryl hydrocarbon receptor target genes (CYP1A1, CYP1B1) in TCDD-treated RPE cells. Polychlorinated Dibenzodioxins 108-112 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 97-103 28886471-3 2017 In silico study showed that conformational changes and energies involved in the binding of TCDD to cytochrome P450 1B1 (CYP1B1) were crucial for its target proteins. Polychlorinated Dibenzodioxins 91-95 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 99-118 28886471-3 2017 In silico study showed that conformational changes and energies involved in the binding of TCDD to cytochrome P450 1B1 (CYP1B1) were crucial for its target proteins. Polychlorinated Dibenzodioxins 91-95 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 120-126 28886471-5 2017 Further, TCDD-CYP1B1 complex showed strong binding affinity for caspase 3, showing a binding energy of -518.5 Kcal/mol, and the docking of caspase inhibitors in the complex showed weak interaction with low binding energy as compared to TCDD-CYP1B1 caspase complexes. Polychlorinated Dibenzodioxins 9-13 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 14-20 28886471-5 2017 Further, TCDD-CYP1B1 complex showed strong binding affinity for caspase 3, showing a binding energy of -518.5 Kcal/mol, and the docking of caspase inhibitors in the complex showed weak interaction with low binding energy as compared to TCDD-CYP1B1 caspase complexes. Polychlorinated Dibenzodioxins 9-13 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 241-247 28886471-5 2017 Further, TCDD-CYP1B1 complex showed strong binding affinity for caspase 3, showing a binding energy of -518.5 Kcal/mol, and the docking of caspase inhibitors in the complex showed weak interaction with low binding energy as compared to TCDD-CYP1B1 caspase complexes. Polychlorinated Dibenzodioxins 236-240 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 14-20 28886471-8 2017 The role of CYP1B1 and AhR in DNA damage and apoptosis was demonstrated, and clotrimazole as well as knockdown of CYP1B1 and AhR could inhibit TCDD activation and suppress DNA damage followed by apoptosis in HaCaT cells. Polychlorinated Dibenzodioxins 143-147 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 12-18 28886471-8 2017 The role of CYP1B1 and AhR in DNA damage and apoptosis was demonstrated, and clotrimazole as well as knockdown of CYP1B1 and AhR could inhibit TCDD activation and suppress DNA damage followed by apoptosis in HaCaT cells. Polychlorinated Dibenzodioxins 143-147 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 114-120 28886471-10 2017 This study highlights the critical role of CYP1B1 and AhR in TCDD activity and proposes that inhibition of these key molecules might serve as a potential therapeutic approach for treatment of allergy and cancer. Polychlorinated Dibenzodioxins 61-65 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 43-49