PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21145940-1	2011	BACKGROUND: Activation of the protein tyrosine kinase c-Src (c-Src kinase) induced by the exposure to the environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) has been shown in various cell types.	Polychlorinated Dibenzodioxins	130-165	C-terminal Src kinase	Homo sapiens	61-73	
21145940-1	2011	BACKGROUND: Activation of the protein tyrosine kinase c-Src (c-Src kinase) induced by the exposure to the environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) has been shown in various cell types.	Polychlorinated Dibenzodioxins	167-171	C-terminal Src kinase	Homo sapiens	61-73	
21145940-5	2011	Data from FRET assay visualized and quantified the activation of c-Src kinase induced by TCDD in living cells of both cell types.	Polychlorinated Dibenzodioxins	89-93	C-terminal Src kinase	Homo sapiens	65-77	
9707505-13	1998	(2) TCDD-induced, AhR-associated c-Src kinase activity was abolished when an AhR immunoprecipitate from cervical cells was preincubated with alpha-naphthoflavone (AhR blocker) or geldanamycin (Src kinase inhibitor) prior to the addition of TCDD.	Polychlorinated Dibenzodioxins	4-8	C-terminal Src kinase	Homo sapiens	33-45	
17223712-1	2007	We investigated the mechanism by which activation of the Ah receptor by dioxin (TCDD) was accompanied by rapid activation of c-Src kinase activity.	Polychlorinated Dibenzodioxins	80-84	C-terminal Src kinase	Homo sapiens	125-137	
17223712-8	2007	Interestingly, such a role of cdc37 in mediating the action of TCDD appears to be limited to activation of c-Src kinase, but not kinases associated with activation of NFkB, C/EBPalpha, or ERK.	Polychlorinated Dibenzodioxins	63-67	C-terminal Src kinase	Homo sapiens	107-119	
15674841-0	2004	Studies on the mechanism of rapid activation of protein tyrosine phosphorylation activities, particularly c-Src kinase, by TCDD in MCF10A.	Polychlorinated Dibenzodioxins	123-127	C-terminal Src kinase	Homo sapiens	106-118	
15674841-10	2004	These results support the conclusion that c-Src kinase is at least one of the earliest and the most upstream components of toxic signaling of the Ah-receptor activated by TCDD through the post-transcriptional process.	Polychlorinated Dibenzodioxins	171-175	C-terminal Src kinase	Homo sapiens	42-54	
15674848-0	2004	TCDD causes suppression of growth and differentiation of MCF10A, human mammary epithelial cells by interfering with their insulin receptor signaling through c-Src kinase and ERK activation.	Polychlorinated Dibenzodioxins	0-4	C-terminal Src kinase	Homo sapiens	157-169	
15674848-5	2004	To test the hypothesis that TCDD-induced c-Src kinase activation is casually related to this compound"s antagonistic action against insulin, we treated MCF10A cells with two c-Src blocking agents, an anti-Src antisense oligonucleotides blocker and a known specific inhibitor of c-Src kinase, PP-2 and studied the effect of insulin and TCDD on cell proliferation.	Polychlorinated Dibenzodioxins	28-32	C-terminal Src kinase	Homo sapiens	41-53	
15674848-5	2004	To test the hypothesis that TCDD-induced c-Src kinase activation is casually related to this compound"s antagonistic action against insulin, we treated MCF10A cells with two c-Src blocking agents, an anti-Src antisense oligonucleotides blocker and a known specific inhibitor of c-Src kinase, PP-2 and studied the effect of insulin and TCDD on cell proliferation.	Polychlorinated Dibenzodioxins	28-32	C-terminal Src kinase	Homo sapiens	278-290	
9707505-8	1998	A marked increase in the protein amount of H-Ras and a significant increase in the activity of c-Src kinase, PTK, and Erk2 were found in cells from TCDD-treated animals.	Polychlorinated Dibenzodioxins	148-152	C-terminal Src kinase	Homo sapiens	95-107	
9707505-12	1998	(1) A structure-activity relationship study with TCDD and three dioxin congeners revealed a rank order for their potency in activation of AhR-associated c-Src kinase from cervical cells which was identical to that of previously determined toxicity indices.	Polychlorinated Dibenzodioxins	49-53	C-terminal Src kinase	Homo sapiens	153-165	
9707505-13	1998	(2) TCDD-induced, AhR-associated c-Src kinase activity was abolished when an AhR immunoprecipitate from cervical cells was preincubated with alpha-naphthoflavone (AhR blocker) or geldanamycin (Src kinase inhibitor) prior to the addition of TCDD.	Polychlorinated Dibenzodioxins	240-244	C-terminal Src kinase	Homo sapiens	33-45