PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9353419-0	1997	Inhibition of NFkappaB-mediated interleukin-1beta-stimulated prostaglandin E2 formation by the marine natural product hymenialdisine.	hymenialdisine	118-132	nuclear factor kappa B subunit 1	Homo sapiens	14-22	
9353419-3	1997	Hymenialdisine, a marine natural product has recently been characterized as an inhibitor of NFkappaB activation and exposure of IL-1-stimulated RSF-inhibited PGE2 production in a concentration-dependent manner (IC50 approximately 1 microM).	hymenialdisine	0-14	nuclear factor kappa B subunit 1	Homo sapiens	92-100	
9353419-5	1997	Direct action of hymenialdisine on IL-1-induced NFkappaB activation was demonstrated by a significant reduction (approximately 80%) in NFkappaB binding to the classical kappaB consensus motif (as assessed by electrophoretic mobility shift assay) and inhibition of stimulated p65 migration from the cytosol of treated cells (as assessed by Western analysis).	hymenialdisine	17-31	nuclear factor kappa B subunit 1	Homo sapiens	48-56	
9353419-5	1997	Direct action of hymenialdisine on IL-1-induced NFkappaB activation was demonstrated by a significant reduction (approximately 80%) in NFkappaB binding to the classical kappaB consensus motif (as assessed by electrophoretic mobility shift assay) and inhibition of stimulated p65 migration from the cytosol of treated cells (as assessed by Western analysis).	hymenialdisine	17-31	nuclear factor kappa B subunit 1	Homo sapiens	135-143	
9353419-8	1997	Specificity of action is suggested as IL-1-stimulated interleukin-8 (IL-8) production, which is known to be an NFkappaB-regulated event, was also inhibited by hymenialdisine, whereas IL-1-induced production of vascular endothelial growth factor, a non-NFkappaB-regulated gene, was not affected by exposure to hymenialdisine.	hymenialdisine	159-173	nuclear factor kappa B subunit 1	Homo sapiens	111-119	
9353419-8	1997	Specificity of action is suggested as IL-1-stimulated interleukin-8 (IL-8) production, which is known to be an NFkappaB-regulated event, was also inhibited by hymenialdisine, whereas IL-1-induced production of vascular endothelial growth factor, a non-NFkappaB-regulated gene, was not affected by exposure to hymenialdisine.	hymenialdisine	159-173	nuclear factor kappa B subunit 1	Homo sapiens	252-260	
9353419-9	1997	Taken together, hymenialdisine inhibits IL-1-stimulated-RSF PGE2 formation acting predominately through modulation of NFkappaB activation and offers an interesting novel tool to evaluate the role of NFkappaB in inflammatory disease.	hymenialdisine	16-30	nuclear factor kappa B subunit 1	Homo sapiens	118-126	
9353419-9	1997	Taken together, hymenialdisine inhibits IL-1-stimulated-RSF PGE2 formation acting predominately through modulation of NFkappaB activation and offers an interesting novel tool to evaluate the role of NFkappaB in inflammatory disease.	hymenialdisine	16-30	nuclear factor kappa B subunit 1	Homo sapiens	199-207	
35014682-0	2022	10Z-Hymenialdisine inhibits angiogenesis by suppressing NF-kappaB activation in pancreatic cancer cell lines.	hymenialdisine	0-18	nuclear factor kappa B subunit 1	Homo sapiens	56-65