PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21806984-10	2011	Finally, exposure of human colon biopsies from inflammatory bowel diseases patients to rifaximin reduced mRNA levels of IL-8, Rantes, MIP-3alpha and TNFalpha induced by LPS.	Rifaximin	87-96	tumor necrosis factor	Homo sapiens	149-157	
25835116-9	2015	Furthermore, patients on both rifaximin and norfloxacin therapies showed a statistically significant decrease in TNF-alpha and IL-6 serum levels compared with their baseline levels (p=0.000 and p=0.000, respectively).	Rifaximin	30-39	tumor necrosis factor	Homo sapiens	113-122	
16985094-1	2006	OBJECTIVE: To review the literature on novel immunomodulators such as tumor necrosis factor alpha (TNF-alpha)- and interleukin (IL)-related agents, 6-thioguanine (6-TG), tacrolimus, and leflunomide, and antibiotics such as ornidazole, rifaximin, and ciprofloxacin for the treatment of Crohn"s disease.	Rifaximin	235-244	tumor necrosis factor	Homo sapiens	70-97	
20832949-12	2011	Previous studies in experimental models of cirrhosis and cirrhotic patients have demonstrated that long-term administration of oral antibiotics such as trimethoprim-sulfamethoxazole, norfloxacin, and rifaximin can reduce bacterial translocation and circulating levels of endotoxin, TNF-alpha, IL-6, and NO.	Rifaximin	200-209	tumor necrosis factor	Homo sapiens	282-291	
20816942-8	2010	Knocking down the expression of PXR in colon epithelial cells by an anti-PXR siRNA, abrogated the counter-regulatory effects exerted by rifaximin on cell exposed to TNFalpha.	Rifaximin	136-145	tumor necrosis factor	Homo sapiens	165-173	
20816942-10	2010	In aggregate, these data illustrate that rifaximin increases the expression of PXR and PXR-regulated genes involved in the metabolism and excretion of xenobiotics and antagonizes the effects of TNFalpha in intestinal epithelial cells and colon biopsies.	Rifaximin	41-50	tumor necrosis factor	Homo sapiens	194-202	
16985094-1	2006	OBJECTIVE: To review the literature on novel immunomodulators such as tumor necrosis factor alpha (TNF-alpha)- and interleukin (IL)-related agents, 6-thioguanine (6-TG), tacrolimus, and leflunomide, and antibiotics such as ornidazole, rifaximin, and ciprofloxacin for the treatment of Crohn"s disease.	Rifaximin	235-244	tumor necrosis factor	Homo sapiens	99-108	
34281295-14	2022	TNF-alpha was reduced by rifaximin, which might have resulted in reduced expression of muscular MuRF1 and myostatin and improvements in myofiber diameters within muscle tissues.	Rifaximin	25-34	tumor necrosis factor	Homo sapiens	0-9	
34281295-16	2022	Rifaximin might be effective in reducing TNF-alpha levels and improving sarcopenia in LC, but these results need to be validated in future studies.	Rifaximin	0-9	tumor necrosis factor	Homo sapiens	41-50