PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32598720-9	2020	68% of patients with exacerbation of CP, receiving in addition to the standard regimen rifaximin, achieved clinical improvement, normalization of intestinal biocenosis, reduced concentrations of cytokines in tissues, reducing signs of chronic inflammation in the colon mucosa with reducing concentrations of IL-2, IL-6, IL-8 in colon mucosa (p0.05).	Rifaximin	87-96	interleukin 6	Homo sapiens	314-318	
35582294-11	2022	Both EcN and rifaximin produced similar significant reductions in the proinflammatory cytokines INF-gamma, IL-6 and IL-8.	Rifaximin	13-22	interleukin 6	Homo sapiens	107-111	
20832949-12	2011	Previous studies in experimental models of cirrhosis and cirrhotic patients have demonstrated that long-term administration of oral antibiotics such as trimethoprim-sulfamethoxazole, norfloxacin, and rifaximin can reduce bacterial translocation and circulating levels of endotoxin, TNF-alpha, IL-6, and NO.	Rifaximin	200-209	interleukin 6	Homo sapiens	293-297	
31462286-7	2019	In these responder patients rifaximin normalized all alterations in the immune system measured while in non-responders it normalizes only IL-6, CCL20, and differentiation of T lymphocytes to Th22.	Rifaximin	28-37	interleukin 6	Homo sapiens	138-142	
30096092-7	2018	After 6 months of rifaximin therapy, patients with NASH showed a significant reduction in homeostatic model assessment, alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase, endotoxin, toll-like receptor-4, IL-6, tumor necrosis factor-alpha, CK-18, and NAFLD-liver fat score (all P<0.05), but no changes in the lipid profile; moreover, there was a mild nonstatistically significant reduction of BMI.	Rifaximin	18-27	interleukin 6	Homo sapiens	235-268	
25835116-9	2015	Furthermore, patients on both rifaximin and norfloxacin therapies showed a statistically significant decrease in TNF-alpha and IL-6 serum levels compared with their baseline levels (p=0.000 and p=0.000, respectively).	Rifaximin	30-39	interleukin 6	Homo sapiens	127-131