PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21031626-0	2010	Reversible inhibition of three important human liver cytochrome p450 enzymes by tiliroside.	tiliroside	80-90	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	53-68	
21031626-3	2010	The inhibition of seven CYP isoforms (CYP3A4, CYP1A2, CYP2A6, CYP2D6, CYP2C9, CYP2C8 and CYP2E1) by tiliroside was investigated using in vitro human liver microsomal incubation assays.	tiliroside	100-110	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	24-27	
21031626-4	2010	The results showed that tiliroside strongly inhibited the activity of CYP3A4 (IC(50) = 9.0 +- 1.7 mum), CYP2C8 (IC(50) = 12.1 +- 0.9 mum) and CYP2C9 (IC(50) = 10.2 +- 0.9 mum) with other CYP isoforms negligibly influenced.	tiliroside	24-34	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	70-73	
21031626-5	2010	Further kinetic analysis showed that inhibition of these three CYP isoforms by tiliroside is best fit to a competitive way.	tiliroside	79-89	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	63-66	
21031626-7	2010	The relatively low K(i) values suggested that tiliroside might induce drug-drug interactions with many clinically used drugs which are mainly metabolized by these three CYP isoforms.	tiliroside	46-56	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	169-172