PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10083838-1 1999 The ursane triterpenoid alpha-amyrin and the lupane triterpenoid lupeol are potent inhibitors of the catalytic subunit (cAK) of rat liver cyclic AMP-dependent protein kinase (PKA) with IC50 values of 8 and 5 microM, respectively. beta-amyrin 24-36 KIT proto-oncogene receptor tyrosine kinase Rattus norvegicus 159-173 10083838-1 1999 The ursane triterpenoid alpha-amyrin and the lupane triterpenoid lupeol are potent inhibitors of the catalytic subunit (cAK) of rat liver cyclic AMP-dependent protein kinase (PKA) with IC50 values of 8 and 5 microM, respectively. beta-amyrin 24-36 KIT proto-oncogene receptor tyrosine kinase Rattus norvegicus 175-178 10083838-3 1999 alpha-Amyrin, lupeol and lupeol linoleate are much less potent as inhibitors of rat brain Ca(2+)- and phospholipid-dependent protein kinase (PKC) (IC50 values 32, 82 and 35 microM; respectively) and alpha-amyrin linoleate and the palmitate esters of lupeol and alpha-amyrin are ineffective or very poor inhibitors of this protein kinase. beta-amyrin 0-12 KIT proto-oncogene receptor tyrosine kinase Rattus norvegicus 322-336 10083838-5 1999 alpha-Amyrin inhibits plant Ca(2+)-dependent protein kinase (CDPK) (IC50 52 microM) but lupeol and the triterpenoid esters tested are ineffective. beta-amyrin 0-12 KIT proto-oncogene receptor tyrosine kinase Rattus norvegicus 45-59