PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23029106-0	2012	A novel small molecule FL118 that selectively inhibits survivin, Mcl-1, XIAP and cIAP2 in a p53-independent manner, shows superior antitumor activity.	7-ethyl-7-hydroxy-10H-1,3-Dioxolo(4,5-g)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-8,11(7H,12H)-dione	23-28	tumor protein p53	Homo sapiens	92-95	
25512388-0	2014	FL118 induces p53-dependent senescence in colorectal cancer cells by promoting degradation of MdmX.	7-ethyl-7-hydroxy-10H-1,3-Dioxolo(4,5-g)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-8,11(7H,12H)-dione	0-5	tumor protein p53	Homo sapiens	14-17	
25512388-4	2014	Here, we report that FL118 activates tumor suppressor p53 as a novel MOA in p53 wild-type cancer cells.	7-ethyl-7-hydroxy-10H-1,3-Dioxolo(4,5-g)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-8,11(7H,12H)-dione	21-26	tumor protein p53	Homo sapiens	54-57	
25512388-4	2014	Here, we report that FL118 activates tumor suppressor p53 as a novel MOA in p53 wild-type cancer cells.	7-ethyl-7-hydroxy-10H-1,3-Dioxolo(4,5-g)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-8,11(7H,12H)-dione	21-26	tumor protein p53	Homo sapiens	76-79	
25512388-6	2014	FL118 inhibits p53 polyubiquitination and monoubiquitination by Mdm2-MdmX E3 complex in cells and in cell-free systems.	7-ethyl-7-hydroxy-10H-1,3-Dioxolo(4,5-g)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-8,11(7H,12H)-dione	0-5	tumor protein p53	Homo sapiens	15-18	
25512388-8	2014	Coimmunoprecipitation revealed that FL118 slightly decreases Mdm2-p53 interactions and moderately increases Mdm2-MdmX interactions, suggesting a change of targeting specificity of Mdm2-MdmX E3 complex from p53 to MdmX, resulting in accelerated MdmX degradation.	7-ethyl-7-hydroxy-10H-1,3-Dioxolo(4,5-g)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-8,11(7H,12H)-dione	36-41	tumor protein p53	Homo sapiens	66-69	
25512388-8	2014	Coimmunoprecipitation revealed that FL118 slightly decreases Mdm2-p53 interactions and moderately increases Mdm2-MdmX interactions, suggesting a change of targeting specificity of Mdm2-MdmX E3 complex from p53 to MdmX, resulting in accelerated MdmX degradation.	7-ethyl-7-hydroxy-10H-1,3-Dioxolo(4,5-g)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-8,11(7H,12H)-dione	36-41	tumor protein p53	Homo sapiens	206-209	
25512388-10	2014	Activation of the p53 pathway by FL118 induces p53-dependent senescence in colorectal cancer cells.	7-ethyl-7-hydroxy-10H-1,3-Dioxolo(4,5-g)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-8,11(7H,12H)-dione	33-38	tumor protein p53	Homo sapiens	18-21	
25512388-10	2014	Activation of the p53 pathway by FL118 induces p53-dependent senescence in colorectal cancer cells.	7-ethyl-7-hydroxy-10H-1,3-Dioxolo(4,5-g)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-8,11(7H,12H)-dione	33-38	tumor protein p53	Homo sapiens	47-50	
25512388-11	2014	However, in the absence of p53 or in the presence of MdmX overexpression, FL118 promotes p53-independent apoptosis.	7-ethyl-7-hydroxy-10H-1,3-Dioxolo(4,5-g)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-8,11(7H,12H)-dione	74-79	tumor protein p53	Homo sapiens	89-92	
24959385-10	2014	Importantly, inhibition of these target genes and of tumor growth by FL118 is independent of p53 status (wild type, mutant or null), although mechanisms of action may be distinct among cells with different p53 status.	7-ethyl-7-hydroxy-10H-1,3-Dioxolo(4,5-g)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-8,11(7H,12H)-dione	69-74	tumor protein p53	Homo sapiens	206-209	
24959385-11	2014	Therefore, FL118 may effectively control cancer that loses functional p53, in which most DNA damage drugs (if not all) show a marked lack of efficiency.	7-ethyl-7-hydroxy-10H-1,3-Dioxolo(4,5-g)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-8,11(7H,12H)-dione	11-16	tumor protein p53	Homo sapiens	70-73	
23029106-7	2012	Moreover, FL118 selectively inhibited survivin promoter activity and gene expression also in a p53 status-independent manner.	7-ethyl-7-hydroxy-10H-1,3-Dioxolo(4,5-g)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-8,11(7H,12H)-dione	10-15	tumor protein p53	Homo sapiens	95-98	
23029106-8	2012	Although the survivin promoter-reporter system was used for the identification of FL118, our studies revealed that FL118 not only inhibits survivin expression but also selectively and independently inhibits three additional cancer-associated survival genes (Mcl-1, XIAP and cIAP2) in a p53 status-independent manner, while showing no inhibitory effects on control genes.	7-ethyl-7-hydroxy-10H-1,3-Dioxolo(4,5-g)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-8,11(7H,12H)-dione	115-120	tumor protein p53	Homo sapiens	286-289	
34377229-5	2021	This finding suggests that both KrasG12V and KrasG12D are required for showing higher FL118 efficacy, while the presence of KrasG13D could somehow decrease FL118 efficacy under the defined p53/APC genetic status.	7-ethyl-7-hydroxy-10H-1,3-Dioxolo(4,5-g)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-8,11(7H,12H)-dione	156-161	tumor protein p53	Homo sapiens	189-192	
34377229-10	2021	These findings would be useful for predicting FL118 sensitivity to patients" CRC tumors with the defined Kras mutation subtypes under the defined p53/APC genetic status.	7-ethyl-7-hydroxy-10H-1,3-Dioxolo(4,5-g)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-8,11(7H,12H)-dione	46-51	tumor protein p53	Homo sapiens	146-149