PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34343636-8	2021	The AKT1/FOXP3 axis mediated the CerS6 expression and promoted p53 mutant pancreatic tumorigenesis by producing excessive C16-ceramide, which induced the accumulation of mutant p53.	N-palmitoylsphingosine	122-134	tumor protein p53	Homo sapiens	63-66	
34343636-8	2021	The AKT1/FOXP3 axis mediated the CerS6 expression and promoted p53 mutant pancreatic tumorigenesis by producing excessive C16-ceramide, which induced the accumulation of mutant p53.	N-palmitoylsphingosine	122-134	tumor protein p53	Homo sapiens	177-180	
18400537-10	2008	These studies indicate that p53 specifically drives de novo ceramide synthesis by activation of a ceramide synthase that favors the synthesis of N-palmitoylsphingosine.	N-palmitoylsphingosine	145-167	tumor protein p53	Homo sapiens	28-31	
30297838-0	2018	C16-ceramide is a natural regulatory ligand of p53 in cellular stress response.	N-palmitoylsphingosine	0-12	tumor protein p53	Homo sapiens	47-50	
30297838-2	2018	Here we report the mechanism for activation of p53 tumor suppressor by C16-ceramide.	N-palmitoylsphingosine	71-83	tumor protein p53	Homo sapiens	47-50	
30297838-3	2018	C16-ceramide tightly binds within the p53 DNA-binding domain (Kd ~ 60 nM), in close vicinity to the Box V motif.	N-palmitoylsphingosine	0-12	tumor protein p53	Homo sapiens	38-41	
30297838-8	2018	Our study establishes C16-ceramide as a natural small molecule activating p53 through the direct binding.	N-palmitoylsphingosine	22-34	tumor protein p53	Homo sapiens	74-77	
18400537-0	2008	De novo N-palmitoylsphingosine synthesis is the major biochemical mechanism of ceramide accumulation following p53 up-regulation.	N-palmitoylsphingosine	8-30	tumor protein p53	Homo sapiens	111-114	
18400537-5	2008	In both Molt-4 LXSN leukemia cells exposed to gamma-irradiation and in EB-1 colon cancer cells treated with ZnCl(2), p53 up-regulation led to de novo ceramide synthesis with predominance of N-palmitoylsphingosine (C16-ceramide) synthesis.	N-palmitoylsphingosine	190-212	tumor protein p53	Homo sapiens	117-120	
18400537-5	2008	In both Molt-4 LXSN leukemia cells exposed to gamma-irradiation and in EB-1 colon cancer cells treated with ZnCl(2), p53 up-regulation led to de novo ceramide synthesis with predominance of N-palmitoylsphingosine (C16-ceramide) synthesis.	N-palmitoylsphingosine	214-226	tumor protein p53	Homo sapiens	117-120	
34062962-6	2021	We therefore determined how modulation of C16-ceramide, either through CerS6 or p53, a known PGCC suppressor and enhancer of CerS6-derived C16-ceramide, affected PGCC progeny formation.	N-palmitoylsphingosine	42-54	tumor protein p53	Homo sapiens	80-83	
34062962-6	2021	We therefore determined how modulation of C16-ceramide, either through CerS6 or p53, a known PGCC suppressor and enhancer of CerS6-derived C16-ceramide, affected PGCC progeny formation.	N-palmitoylsphingosine	139-151	tumor protein p53	Homo sapiens	80-83