PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25039814-11 2015 As telaprevir has been shown to inhibit mostly the drug transporter OCT2 which interacts with creatinine transport, the early decrease of eGFR observed could be a benign phenomenon. telaprevir 3-13 POU class 2 homeobox 2 Homo sapiens 68-72 24390473-2 2014 We speculated that this effect reflects inhibition of the renal organic cation transporters hOCT2, hMATE1, and hMATE2-K by telaprevir or its metabolites (VRT-127394 and VRT-0922061). telaprevir 123-133 POU class 2 homeobox 2 Homo sapiens 92-97 22902721-6 2012 Telaprevir was shown to exhibit significant inhibition of the human renal drug transporters OCT2 and MATE1 with IC(50) values of 6.4 muM and 23.0 muM, respectively, whereas no inhibitory effect on OAT1 and OAT3 mediated transport by telaprevir was demonstrated. telaprevir 0-10 POU class 2 homeobox 2 Homo sapiens 92-96