PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22902721-6 2012 Telaprevir was shown to exhibit significant inhibition of the human renal drug transporters OCT2 and MATE1 with IC(50) values of 6.4 muM and 23.0 muM, respectively, whereas no inhibitory effect on OAT1 and OAT3 mediated transport by telaprevir was demonstrated. telaprevir 0-10 solute carrier family 47 member 1 Homo sapiens 101-106 24390473-2 2014 We speculated that this effect reflects inhibition of the renal organic cation transporters hOCT2, hMATE1, and hMATE2-K by telaprevir or its metabolites (VRT-127394 and VRT-0922061). telaprevir 123-133 solute carrier family 47 member 1 Homo sapiens 99-105 24390473-3 2014 Telaprevir, VRT-127394, and VRT-0922061 showed negligible or weak effects on hOCT2 at concentrations of >=20 microM, but inhibited hMATE1 by 35, 38, and 53% and hMATE2-K by 47, 45, and 61% at 100 microM, respectively. telaprevir 0-10 solute carrier family 47 member 1 Homo sapiens 134-140