PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24332840-0	2014	Telaprevir is a substrate and moderate inhibitor of P-glycoprotein, a strong inductor of ABCG2, but not an activator of PXR in vitro.	telaprevir	0-10	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	89-94	
24332840-2	2014	The in vitro potency of telaprevir to inhibit P-glycoprotein (P-gp, ABCB1) and breast cancer resistance protein (BCRP, ABCG2) was assessed and its substrate characteristics for P-gp, BCRP and the multidrug resistance-associated proteins (MRPs, ABCCs) 1-3 were evaluated.	telaprevir	24-34	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	79-111	
24332840-2	2014	The in vitro potency of telaprevir to inhibit P-glycoprotein (P-gp, ABCB1) and breast cancer resistance protein (BCRP, ABCG2) was assessed and its substrate characteristics for P-gp, BCRP and the multidrug resistance-associated proteins (MRPs, ABCCs) 1-3 were evaluated.	telaprevir	24-34	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	113-117	
24332840-2	2014	The in vitro potency of telaprevir to inhibit P-glycoprotein (P-gp, ABCB1) and breast cancer resistance protein (BCRP, ABCG2) was assessed and its substrate characteristics for P-gp, BCRP and the multidrug resistance-associated proteins (MRPs, ABCCs) 1-3 were evaluated.	telaprevir	24-34	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	119-124	
24332840-2	2014	The in vitro potency of telaprevir to inhibit P-glycoprotein (P-gp, ABCB1) and breast cancer resistance protein (BCRP, ABCG2) was assessed and its substrate characteristics for P-gp, BCRP and the multidrug resistance-associated proteins (MRPs, ABCCs) 1-3 were evaluated.	telaprevir	24-34	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	183-187	
24332840-6	2014	In LS180 cells, telaprevir strongly induced mRNA expression of ABCG2 (4.3-fold at 30 mumol/L) and weakly induced ABCB11, CYP2C19 and UGT1A3.	telaprevir	16-26	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	63-68	
24196382-4	2013	We studied the kinetics of in vitro interactions between telaprevir and P-gp and BCRP to understand the molecular basis of that interaction.	telaprevir	57-67	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	81-85	
24196382-5	2013	FINDINGS: The effect of telaprevir on P-gp- and BCRP-mediated transport was evaluated by an in vitro vesicle transporter assay using different transport substrates, and the kinetics of transporter inhibition was determined.	telaprevir	24-34	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	48-52	
24196382-6	2013	The results showed that telaprevir could inhibit P-gp- and BCRP-mediated transport in the in vitro vesicle transport assay, with each IC50 values of   7 mumol/L and   30 mumol/L, respectively.	telaprevir	24-34	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	59-63	
24196382-7	2013	Analyses of Lineweaver-Burk plots showed that telaprevir was likely to be a competitive inhibitor against P-gp and BCRP.	telaprevir	46-56	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	115-119	
24196382-8	2013	Photoaffinity labeling experiments were employed to observe competitive inhibition by telaprevir using iodoarylazidoprazosin (IAAP) as a binding substrate for P-gp and BCRP.	telaprevir	86-96	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	168-172	
24196382-9	2013	These experiments revealed that telaprevir inhibited [125I]-IAAP-binding with P-gp and BCRP.	telaprevir	32-42	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	87-91	
24196382-10	2013	CONCLUSION: Telaprevir competitively inhibited P-gp and BCRP, and P-gp-mediated transport was more sensitive to telaprevir compared with BCRP-mediated transport.	telaprevir	12-22	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	56-60	
24196382-11	2013	These data suggest that telaprevir represses the transporter functions of P-gp and BCRP via direct inhibition.	telaprevir	24-34	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	83-87