PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26721276-5 2016 Furthermore, acetic acid can also be transported by facilitated diffusion via Fps1 channel. Acetic Acid 13-24 Fps1p Saccharomyces cerevisiae S288C 78-82 17620418-0 2007 Hog1 mitogen-activated protein kinase phosphorylation targets the yeast Fps1 aquaglyceroporin for endocytosis, thereby rendering cells resistant to acetic acid. Acetic Acid 148-159 Fps1p Saccharomyces cerevisiae S288C 72-76 17620418-6 2007 As Fps1 is the membrane channel that facilitates passive diffusional flux of undissociated acetic acid into the cell, this loss downregulates such influx in low-pH cultures, where acetic acid (pKa, 4.75) is substantially undissociated. Acetic Acid 91-102 Fps1p Saccharomyces cerevisiae S288C 3-7 17620418-6 2007 As Fps1 is the membrane channel that facilitates passive diffusional flux of undissociated acetic acid into the cell, this loss downregulates such influx in low-pH cultures, where acetic acid (pKa, 4.75) is substantially undissociated. Acetic Acid 180-191 Fps1p Saccharomyces cerevisiae S288C 3-7 17620418-7 2007 Consistent with this downregulation of the acid entry generating resistance, sensitivity to acetic acid is seen with diverse mutational defects that abolish endocytic removal of Fps1 from the plasma membrane (loss of Hog1, loss of the soluble domains of Fps1, a T231A S537A double mutation of Fps1 that prevents its in vivo phosphorylation, or mutations generating a general loss of endocytosis of cell surface proteins [doa4Delta and end3Delta]). Acetic Acid 92-103 Fps1p Saccharomyces cerevisiae S288C 178-182 17620418-7 2007 Consistent with this downregulation of the acid entry generating resistance, sensitivity to acetic acid is seen with diverse mutational defects that abolish endocytic removal of Fps1 from the plasma membrane (loss of Hog1, loss of the soluble domains of Fps1, a T231A S537A double mutation of Fps1 that prevents its in vivo phosphorylation, or mutations generating a general loss of endocytosis of cell surface proteins [doa4Delta and end3Delta]). Acetic Acid 92-103 Fps1p Saccharomyces cerevisiae S288C 254-258 17620418-7 2007 Consistent with this downregulation of the acid entry generating resistance, sensitivity to acetic acid is seen with diverse mutational defects that abolish endocytic removal of Fps1 from the plasma membrane (loss of Hog1, loss of the soluble domains of Fps1, a T231A S537A double mutation of Fps1 that prevents its in vivo phosphorylation, or mutations generating a general loss of endocytosis of cell surface proteins [doa4Delta and end3Delta]). Acetic Acid 92-103 Fps1p Saccharomyces cerevisiae S288C 254-258 17620418-8 2007 Remarkably, targetting of Fps1 for degradation may be the major requirement for an active Hog1 in acetic acid resistance, since Hog1 is largely dispensable for such resistance when the cells lack Fps1. Acetic Acid 98-109 Fps1p Saccharomyces cerevisiae S288C 26-30 18240334-3 2008 Acquisition of resistance to acetic acid involves loss of Fps1p, the aquaglyceroporin of the plasma membrane that facilitates the passive diffusional entry of this acid into cells. Acetic Acid 29-40 Fps1p Saccharomyces cerevisiae S288C 58-63 19608606-0 2009 Presence of the Fps1p aquaglyceroporin channel is essential for Hog1p activation, but suppresses Slt2(Mpk1)p activation, with acetic acid stress of yeast. Acetic Acid 126-137 Fps1p Saccharomyces cerevisiae S288C 16-21 19608606-1 2009 When grown at pH 4.5, Saccharomyces cerevisiae acquires a resistance to inhibitory acetic acid levels ( approximately 0.1 M) by destabilizing Fps1p, the plasma membrane aquaglyceroporin that provides the main route for passive diffusional entry of this acid into the cell. Acetic Acid 83-94 Fps1p Saccharomyces cerevisiae S288C 142-147 19608606-2 2009 Acetic acid stress transiently activates Hog1p mitogen-activated protein (MAP) kinase, which, in turn, phosphorylates Fps1p in order to target this channel for endocytosis and degradation in the vacuole. Acetic Acid 0-11 Fps1p Saccharomyces cerevisiae S288C 118-123 19608606-8 2009 Lack of Fps1p therefore exerts opposing effects on the activation of Hog1p and Slt2p in yeast exposed to acetic acid stress. Acetic Acid 105-116 Fps1p Saccharomyces cerevisiae S288C 8-13 20953665-0 2011 Improvement of acetic acid tolerance and fermentation performance of Saccharomyces cerevisiae by disruption of the FPS1 aquaglyceroporin gene. Acetic Acid 15-26 Fps1p Saccharomyces cerevisiae S288C 115-119 20953665-4 2011 FPS1 gene disruption in an industrial ethanologenic yeast thus increases cell growth and ethanol yield under acetic acid stress, which suggests the potential utility of FPS1 gene disruption for bioethanol production from renewable resources such as lignocelluloses. Acetic Acid 109-120 Fps1p Saccharomyces cerevisiae S288C 0-4 22050823-5 2011 In baker"s yeast (Saccharomyces cerevisiae), resistance to high acetic acid is acquired partly by loss of the plasma membrane aquaglyceroporin that facilitates the passive diffusional entry of undissociated acid into cells (Fps1), and partly through a transcriptional response mediated by the transcription factor Haa1. Acetic Acid 64-75 Fps1p Saccharomyces cerevisiae S288C 224-228 20491941-1 2010 Saccharomyces cerevisiae acquires a resistance to high, toxic levels of acetic acid by destabilizing Fps1p, the plasma membrane aquaglyceroporin through which this acid - in its undissociated state - enters the cell. Acetic Acid 72-83 Fps1p Saccharomyces cerevisiae S288C 101-106 20491941-2 2010 In this study, Fps1p loss was shown to confer resistances to acetic acid, acrolein and allyl alcohol, not just in S. cerevisiae but also in the osmotolerant spoilage yeast Zygosaccharomyces rouxii. Acetic Acid 61-72 Fps1p Saccharomyces cerevisiae S288C 15-20 18240334-4 2008 Acetic acid stress transiently activates Hog1p mitogen-activated protein kinase, which then directly phosphorylates Fps1p in order to target this channel for endocytosis and degradation in the vacuole. Acetic Acid 0-11 Fps1p Saccharomyces cerevisiae S288C 116-121