PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12147235-1 2002 Delta-6 Desaturase (D6D) catalyzes the first step of the synthesis of highly unsaturated fatty acids (HUFA) that play pivotal roles in many biological functions. hufa 102-106 fatty acid desaturase 2 Homo sapiens 0-18 12147235-1 2002 Delta-6 Desaturase (D6D) catalyzes the first step of the synthesis of highly unsaturated fatty acids (HUFA) that play pivotal roles in many biological functions. hufa 102-106 fatty acid desaturase 2 Homo sapiens 20-23 28657495-2 2018 The fatty acyl delta6-desaturase (Delta6 desaturase) is a rate-limiting enzyme in the biosynthetic pathway of highly unsaturated fatty acids (HUFA) that converts polyunsaturated fatty acids (PUFA) such as linoleic (18:2n-6) and alpha-linolenic (18:3n-3) acids into HUFA. hufa 142-146 fatty acid desaturase 2 Homo sapiens 15-32 28657495-2 2018 The fatty acyl delta6-desaturase (Delta6 desaturase) is a rate-limiting enzyme in the biosynthetic pathway of highly unsaturated fatty acids (HUFA) that converts polyunsaturated fatty acids (PUFA) such as linoleic (18:2n-6) and alpha-linolenic (18:3n-3) acids into HUFA. hufa 142-146 fatty acid desaturase 2 Homo sapiens 40-51 28657495-2 2018 The fatty acyl delta6-desaturase (Delta6 desaturase) is a rate-limiting enzyme in the biosynthetic pathway of highly unsaturated fatty acids (HUFA) that converts polyunsaturated fatty acids (PUFA) such as linoleic (18:2n-6) and alpha-linolenic (18:3n-3) acids into HUFA. hufa 265-269 fatty acid desaturase 2 Homo sapiens 15-32 28657495-2 2018 The fatty acyl delta6-desaturase (Delta6 desaturase) is a rate-limiting enzyme in the biosynthetic pathway of highly unsaturated fatty acids (HUFA) that converts polyunsaturated fatty acids (PUFA) such as linoleic (18:2n-6) and alpha-linolenic (18:3n-3) acids into HUFA. hufa 265-269 fatty acid desaturase 2 Homo sapiens 40-51 28657495-8 2018 Herein, we report, for the first time, a 3D native structure of Delta6 desaturase protein by homology modeling approach; molecular docking analysis was performed with linoleic (18:2n-6) and alpha-linolenic (18:3n-3) acids, which are the two key substrates in the HUFA biosynthetic pathway. hufa 263-267 fatty acid desaturase 2 Homo sapiens 70-81 28657495-9 2018 This work provides insight into the structural and functional characterization of Delta6 desaturase, which is involved in HUFA biosynthesis as a rate-limiting enzyme. hufa 122-126 fatty acid desaturase 2 Homo sapiens 88-99 11724468-2 2001 Following the cloning of mammalian Delta6-desaturase (D6D), the D6D mRNA was found in many tissues, including adult brain, maternal organs, and fetal tissue, suggesting an active synthesis of HUFA in these tissues. hufa 192-196 fatty acid desaturase 2 Homo sapiens 41-52 11724468-2 2001 Following the cloning of mammalian Delta6-desaturase (D6D), the D6D mRNA was found in many tissues, including adult brain, maternal organs, and fetal tissue, suggesting an active synthesis of HUFA in these tissues. hufa 192-196 fatty acid desaturase 2 Homo sapiens 54-57 11724468-2 2001 Following the cloning of mammalian Delta6-desaturase (D6D), the D6D mRNA was found in many tissues, including adult brain, maternal organs, and fetal tissue, suggesting an active synthesis of HUFA in these tissues. hufa 192-196 fatty acid desaturase 2 Homo sapiens 64-67 35211495-3 2021 Interactions are particularly relevant with the FADS1 and FADS2 genes, which encode key fatty acid desaturases in the pathway that converts LA and ALA to their long chain (>=20 carbons), highly unsaturated fatty acid (HUFA) counterparts. hufa 218-222 fatty acid desaturase 2 Homo sapiens 58-63