PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17140562-0	2007	Ilimaquinone, a marine sponge metabolite, displays anticancer activity via GADD153-mediated pathway.	ilimaquinone	0-12	DNA damage inducible transcript 3	Homo sapiens	75-82	
24930757-0	2014	Ilimaquinone induces death receptor expression and sensitizes human colon cancer cells to TRAIL-induced apoptosis through activation of ROS-ERK/p38 MAPK-CHOP signaling pathways.	ilimaquinone	0-12	DNA damage inducible transcript 3	Homo sapiens	153-157	
24930757-7	2014	Induction of DR4 and DR5 by ilimaquinone was mediated through up-regulation of CCAAT/enhancer-binding protein homologous protein (CHOP).	ilimaquinone	28-40	DNA damage inducible transcript 3	Homo sapiens	79-128	
24930757-7	2014	Induction of DR4 and DR5 by ilimaquinone was mediated through up-regulation of CCAAT/enhancer-binding protein homologous protein (CHOP).	ilimaquinone	28-40	DNA damage inducible transcript 3	Homo sapiens	130-134	
24930757-9	2014	Finally, the generation of ROS was required for CHOP and DR5 up-regulation by ilimaquinone.	ilimaquinone	78-90	DNA damage inducible transcript 3	Homo sapiens	48-52	
24930757-10	2014	These results demonstrate that ilimaquinone enhanced the sensitivity of human colon cancer cells to TRAIL-induced apoptosis through ROS-ERK/p38 MAPK-CHOP-mediated up-regulation of DR4 and DR5 expression, suggesting that ilimaquinone could be developed into an adjuvant chemotherapeutic drug.	ilimaquinone	31-43	DNA damage inducible transcript 3	Homo sapiens	149-153	
17140562-9	2007	The data demonstrated that ilimaquinone did not activate extracellular signal-regulated kinase and phosphatidylinositol 3-kinase but induce the up-regulation and nuclear translocation of growth arrest and DNA damage inducible gene 153 (CHOP/GADD153).	ilimaquinone	27-39	DNA damage inducible transcript 3	Homo sapiens	236-240	
17140562-9	2007	The data demonstrated that ilimaquinone did not activate extracellular signal-regulated kinase and phosphatidylinositol 3-kinase but induce the up-regulation and nuclear translocation of growth arrest and DNA damage inducible gene 153 (CHOP/GADD153).	ilimaquinone	27-39	DNA damage inducible transcript 3	Homo sapiens	241-248	
17140562-10	2007	Furthermore, ilimaquinone-mediated anti-proliferative effect is significantly reduced in the antisense CHOP/GADD153-overexpressing cells.	ilimaquinone	13-25	DNA damage inducible transcript 3	Homo sapiens	103-107	
17140562-10	2007	Furthermore, ilimaquinone-mediated anti-proliferative effect is significantly reduced in the antisense CHOP/GADD153-overexpressing cells.	ilimaquinone	13-25	DNA damage inducible transcript 3	Homo sapiens	108-115	
17140562-12	2007	In summary, it is suggested that ilimaquinone induces the anti-proliferative effect through the G(1) arrest of the cell cycle and the up-regulation and nuclear translocation of CHOP/GADD153.	ilimaquinone	33-45	DNA damage inducible transcript 3	Homo sapiens	177-181	
17140562-12	2007	In summary, it is suggested that ilimaquinone induces the anti-proliferative effect through the G(1) arrest of the cell cycle and the up-regulation and nuclear translocation of CHOP/GADD153.	ilimaquinone	33-45	DNA damage inducible transcript 3	Homo sapiens	182-189