PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33925873-5 2021 Ilimaquinone induces apoptosis, which is accompanied by multiple biological biomarkers, including the downregulation of Akt, ERK, and Bax, upregulation of p38, loss of mitochondrial membrane potential, increased reactive oxygen species generation, and induced autophagy. ilimaquinone 0-12 mitogen-activated protein kinase 1 Homo sapiens 125-128 24930757-0 2014 Ilimaquinone induces death receptor expression and sensitizes human colon cancer cells to TRAIL-induced apoptosis through activation of ROS-ERK/p38 MAPK-CHOP signaling pathways. ilimaquinone 0-12 mitogen-activated protein kinase 1 Homo sapiens 140-143 24930757-10 2014 These results demonstrate that ilimaquinone enhanced the sensitivity of human colon cancer cells to TRAIL-induced apoptosis through ROS-ERK/p38 MAPK-CHOP-mediated up-regulation of DR4 and DR5 expression, suggesting that ilimaquinone could be developed into an adjuvant chemotherapeutic drug. ilimaquinone 31-43 mitogen-activated protein kinase 1 Homo sapiens 136-139