PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20450929-4	2010	Further, QUIN treatment significantly caused oxidative damage (increased lipid peroxidation, nitrite concentration and depleted endogenous antioxidant defense enzymes), altered mitochondrial enzyme complex (I, II and IV) activities and TNF-alpha level as compared to sham treated animals.	Quinolinic Acid	9-13	tumor necrosis factor	Homo sapiens	236-245	
32765743-3	2020	The increased secretion of proinflammatory cytokines interleukin (IL)-1beta, IL-6, IL-8, and tumor necrosis factor alpha (TNFalpha) provokes neuronal degeneration and apoptosis, whereas IL-6, interferon gamma (IFNgamma), and TNFalpha induce aberrant tryptophane degradation with the accumulation of the end-product quinolinic acid in resident glial cells.	Quinolinic Acid	315-330	tumor necrosis factor	Homo sapiens	93-120	
32765743-3	2020	The increased secretion of proinflammatory cytokines interleukin (IL)-1beta, IL-6, IL-8, and tumor necrosis factor alpha (TNFalpha) provokes neuronal degeneration and apoptosis, whereas IL-6, interferon gamma (IFNgamma), and TNFalpha induce aberrant tryptophane degradation with the accumulation of the end-product quinolinic acid in resident glial cells.	Quinolinic Acid	315-330	tumor necrosis factor	Homo sapiens	122-130	
32694973-6	2020	Inflammatory inducible KYN and BH4 pathways upregulation is characterized by increase in pronociceptive compounds, such as quinolinic acid (QUIN) and BH4, in addition to inflammatory mediators such as interferon gamma (IFN-gamma) and tumor necrosis factor alpha (TNF-alpha).	Quinolinic Acid	123-138	tumor necrosis factor	Homo sapiens	234-261	
32694973-6	2020	Inflammatory inducible KYN and BH4 pathways upregulation is characterized by increase in pronociceptive compounds, such as quinolinic acid (QUIN) and BH4, in addition to inflammatory mediators such as interferon gamma (IFN-gamma) and tumor necrosis factor alpha (TNF-alpha).	Quinolinic Acid	123-138	tumor necrosis factor	Homo sapiens	263-272	
32694973-6	2020	Inflammatory inducible KYN and BH4 pathways upregulation is characterized by increase in pronociceptive compounds, such as quinolinic acid (QUIN) and BH4, in addition to inflammatory mediators such as interferon gamma (IFN-gamma) and tumor necrosis factor alpha (TNF-alpha).	Quinolinic Acid	140-144	tumor necrosis factor	Homo sapiens	234-261	
32694973-6	2020	Inflammatory inducible KYN and BH4 pathways upregulation is characterized by increase in pronociceptive compounds, such as quinolinic acid (QUIN) and BH4, in addition to inflammatory mediators such as interferon gamma (IFN-gamma) and tumor necrosis factor alpha (TNF-alpha).	Quinolinic Acid	140-144	tumor necrosis factor	Homo sapiens	263-272	
31940661-8	2020	Among immune markers, plasma tumor necrosis factor (TNF) was robustly associated with plasma kynurenine (KYN) and KYN/tryptophan (TRP), which was in turn significantly associated with CSF KYN, kynurenic acid, and quinolinic acid.	Quinolinic Acid	213-228	tumor necrosis factor	Homo sapiens	29-50	
31940661-8	2020	Among immune markers, plasma tumor necrosis factor (TNF) was robustly associated with plasma kynurenine (KYN) and KYN/tryptophan (TRP), which was in turn significantly associated with CSF KYN, kynurenic acid, and quinolinic acid.	Quinolinic Acid	213-228	tumor necrosis factor	Homo sapiens	52-55	
15112034-14	2004	TNF-alpha activates indolamine-2,3-dioxygenase with neurotoxic quinolinic acid as the end product.	Quinolinic Acid	63-78	tumor necrosis factor	Homo sapiens	0-9	
9355959-0	1997	Quinolinic acid production by macrophages stimulated with IFN-gamma, TNF-alpha, and IFN-alpha.	Quinolinic Acid	0-15	tumor necrosis factor	Homo sapiens	69-78	
9355959-4	1997	We, therefore, sought to determine the role of tumor necrosis factor-alpha (TNF-alpha) and IFN-alpha in the production of QUIN.	Quinolinic Acid	122-126	tumor necrosis factor	Homo sapiens	47-74	
9355959-4	1997	We, therefore, sought to determine the role of tumor necrosis factor-alpha (TNF-alpha) and IFN-alpha in the production of QUIN.	Quinolinic Acid	122-126	tumor necrosis factor	Homo sapiens	76-85	
9355959-7	1997	Results at 72 h showed significant increases in QUIN production in the cells stimulated with IFN-gamma (10297 +/- 170 nmol/L) and also in those stimulated with IFN-alpha (3600 +/- 113 nmol/L), whereas TNF-alpha-stimulated macrophages produced low levels of QUIN (1108 +/- 23 nmol/L).	Quinolinic Acid	48-52	tumor necrosis factor	Homo sapiens	201-210	
9355959-8	1997	Macrophages stimulated with the cytokine combinations TNF-alpha and IFN-gamma, IFN-alpha, and IFN-gamma, and TNF-alpha and IFN-alpha also resulted in increases in QUIN production (11471 +/- 77.6 nmol/L, 16656 +/- 184 nmol/L, and 3369 +/- 120.5 nmol/L, respectively).	Quinolinic Acid	163-167	tumor necrosis factor	Homo sapiens	54-63	
9355959-8	1997	Macrophages stimulated with the cytokine combinations TNF-alpha and IFN-gamma, IFN-alpha, and IFN-gamma, and TNF-alpha and IFN-alpha also resulted in increases in QUIN production (11471 +/- 77.6 nmol/L, 16656 +/- 184 nmol/L, and 3369 +/- 120.5 nmol/L, respectively).	Quinolinic Acid	163-167	tumor necrosis factor	Homo sapiens	109-118