PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11026501-3 2000 (iii) Can "anti-excitotoxic" levels of KYNA be reached by inhibition of kynurenine-3-hydroxylase (i.e. inhibition of QUIN synthesis and shunts of kynurenine metabolism toward KYNA)? Quinolinic Acid 117-121 kynurenine 3-monooxygenase Rattus norvegicus 72-96 19226371-7 2009 Similar, selective effects of KAT II and KMO inhibition were observed when the inhibitors were applied acutely together with the excitotoxin QUIN, which impairs local KP metabolism. Quinolinic Acid 141-145 kynurenine 3-monooxygenase Rattus norvegicus 41-44 19226371-8 2009 Somewhat different effects of KMO (but not KAT II) inhibition were obtained in rats that had received an intrastriatal QUIN injection 7 days earlier. Quinolinic Acid 119-123 kynurenine 3-monooxygenase Rattus norvegicus 30-33 15206725-1 2003 Kynurenine 3-mono-oxygenase (KMO) inhibitors facilitate kynurenic acid (KYNA) neosynthesis and reduce the formation of 3OH-kynurenine (3-HK) and quinolinic acid (QUIN). Quinolinic Acid 145-160 kynurenine 3-monooxygenase Rattus norvegicus 0-27 15206725-1 2003 Kynurenine 3-mono-oxygenase (KMO) inhibitors facilitate kynurenic acid (KYNA) neosynthesis and reduce the formation of 3OH-kynurenine (3-HK) and quinolinic acid (QUIN). Quinolinic Acid 145-160 kynurenine 3-monooxygenase Rattus norvegicus 29-32 15206725-1 2003 Kynurenine 3-mono-oxygenase (KMO) inhibitors facilitate kynurenic acid (KYNA) neosynthesis and reduce the formation of 3OH-kynurenine (3-HK) and quinolinic acid (QUIN). Quinolinic Acid 162-166 kynurenine 3-monooxygenase Rattus norvegicus 0-27 15206725-1 2003 Kynurenine 3-mono-oxygenase (KMO) inhibitors facilitate kynurenic acid (KYNA) neosynthesis and reduce the formation of 3OH-kynurenine (3-HK) and quinolinic acid (QUIN). Quinolinic Acid 162-166 kynurenine 3-monooxygenase Rattus norvegicus 29-32 15206725-8 2003 Our findings suggest that KMO inhibitors reduce OGD-induced pyramidal cell death by decreasing 3-HK (and possibly QUIN) synthesis. Quinolinic Acid 114-118 kynurenine 3-monooxygenase Rattus norvegicus 26-29 11080194-1 2000 Inhibition of kynurenine 3-hydroxylase suppresses quinolinic acid synthesis and, therefore, shunts all kynurenine metabolism toward kynurenic acid (KYNA) formation. Quinolinic Acid 50-65 kynurenine 3-monooxygenase Rattus norvegicus 14-38