PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7869091-2 1995 3-Hydroxyanthranilic acid oxygenase (3HAO) is the biosynthetic enzyme for quinolinic acid, an endogenous agonist of the NMDA glutamate receptor subtype and a potent neurotoxin. Quinolinic Acid 74-89 3-hydroxyanthranilate 3,4-dioxygenase Rattus norvegicus 37-41 7869091-2 1995 3-Hydroxyanthranilic acid oxygenase (3HAO) is the biosynthetic enzyme for quinolinic acid, an endogenous agonist of the NMDA glutamate receptor subtype and a potent neurotoxin. Quinolinic Acid 74-89 3-hydroxyanthranilate 3,4-dioxygenase Rattus norvegicus 0-35 2527078-2 1989 The latter was investigated by measuring the activities of QUIN"s biosynthetic enzyme, 3-hydroxyanthranilic acid oxygenase (3-HAO) and its degradative enzyme, quinolinic acid phosphoribosyltransferase (QPRT). Quinolinic Acid 59-63 3-hydroxyanthranilate 3,4-dioxygenase Rattus norvegicus 87-122 7953687-0 1994 Immunocytochemical localization of the quinolinic acid synthesizing enzyme, 3-hydroxyanthranilic acid oxygenase, in the rat substantia nigra. Quinolinic Acid 39-54 3-hydroxyanthranilate 3,4-dioxygenase Rattus norvegicus 76-111 7953687-2 1994 In the present study, the immunocytochemical localization of 3-hydroxyanthranilic acid oxygenase (3HAO), the enzyme responsible for the synthesis of quinolinic acid, was examined in the adult rat substantia nigra at the light and electron microscopic levels. Quinolinic Acid 149-164 3-hydroxyanthranilate 3,4-dioxygenase Rattus norvegicus 61-96 7953687-2 1994 In the present study, the immunocytochemical localization of 3-hydroxyanthranilic acid oxygenase (3HAO), the enzyme responsible for the synthesis of quinolinic acid, was examined in the adult rat substantia nigra at the light and electron microscopic levels. Quinolinic Acid 149-164 3-hydroxyanthranilate 3,4-dioxygenase Rattus norvegicus 98-102 2527078-2 1989 The latter was investigated by measuring the activities of QUIN"s biosynthetic enzyme, 3-hydroxyanthranilic acid oxygenase (3-HAO) and its degradative enzyme, quinolinic acid phosphoribosyltransferase (QPRT). Quinolinic Acid 59-63 3-hydroxyanthranilate 3,4-dioxygenase Rattus norvegicus 124-129 11715084-2 2001 QUIN formation from 3HANA is readily prevented by coadministration of the specific 3-hydroxyanthranilate oxygenase inhibitor 4-chloro-3HANA (4-Cl-3HANA). Quinolinic Acid 0-4 3-hydroxyanthranilate 3,4-dioxygenase Rattus norvegicus 83-114 3112306-1 1987 3-Hydroxyanthranilic acid oxygenase (3HAO; EC 1.13.11.6), the biosynthetic enzyme of the endogenous excitotoxin quinolinic acid, was purified to homogeneity from rat liver and partially purified from rat brain. Quinolinic Acid 112-127 3-hydroxyanthranilate 3,4-dioxygenase Rattus norvegicus 0-35 3112306-1 1987 3-Hydroxyanthranilic acid oxygenase (3HAO; EC 1.13.11.6), the biosynthetic enzyme of the endogenous excitotoxin quinolinic acid, was purified to homogeneity from rat liver and partially purified from rat brain. Quinolinic Acid 112-127 3-hydroxyanthranilate 3,4-dioxygenase Rattus norvegicus 37-41 3112306-8 1987 Pure rat 3HAO and its antibodies can be expected to constitute useful tools for the further elucidation of the brain"s quinolinic acid system. Quinolinic Acid 119-134 3-hydroxyanthranilate 3,4-dioxygenase Rattus norvegicus 9-13 11711305-1 2001 The ability of 4,5-, 4,6-disubstituted and 4,5,6-trisubstituted 3-hydroxyanthranilic acid derivatives to reduce the production of the excitotoxin quinolinic acid (QUIN) by inhibition of brain 3-hydroxyanthranilic acid dioxygenase (3-HAO) has been investigated using molecular connectivity indices (0chi(v), 1chi(v), 2chi(v)). Quinolinic Acid 146-161 3-hydroxyanthranilate 3,4-dioxygenase Rattus norvegicus 231-236 11711305-1 2001 The ability of 4,5-, 4,6-disubstituted and 4,5,6-trisubstituted 3-hydroxyanthranilic acid derivatives to reduce the production of the excitotoxin quinolinic acid (QUIN) by inhibition of brain 3-hydroxyanthranilic acid dioxygenase (3-HAO) has been investigated using molecular connectivity indices (0chi(v), 1chi(v), 2chi(v)). Quinolinic Acid 163-167 3-hydroxyanthranilate 3,4-dioxygenase Rattus norvegicus 231-236 3346732-14 1988 The observation that 3HAO and QPRT only partially coexist in hippocampal glial cells suggests that while synthesis and catabolism of QUIN may occur in the same glial cells, catabolism of QUIN can also take place in cells lacking the synthetic enzyme. Quinolinic Acid 133-137 3-hydroxyanthranilate 3,4-dioxygenase Rattus norvegicus 21-25 2940338-0 1986 Synthesis of quinolinic acid by 3-hydroxyanthranilic acid oxygenase in rat brain tissue in vitro. Quinolinic Acid 13-28 3-hydroxyanthranilate 3,4-dioxygenase Rattus norvegicus 32-67 2940338-4 1986 Kinetic analysis of rat forebrain 3HAO revealed a Km of 3.6 +/- 0.5 microM for 3-hydroxyanthranilic acid and a Vmax of 73.7 +/- 9.5 pmol quinolinic acid/h/mg tissue. Quinolinic Acid 137-152 3-hydroxyanthranilate 3,4-dioxygenase Rattus norvegicus 34-38 16855872-6 2006 In addition these agents inhibit the enzyme, 3-hydroxyanthranilic acid oxygenase (3-HAO), responsible for the synthesis of endogenous QA. Quinolinic Acid 134-136 3-hydroxyanthranilate 3,4-dioxygenase Rattus norvegicus 45-80 16855872-6 2006 In addition these agents inhibit the enzyme, 3-hydroxyanthranilic acid oxygenase (3-HAO), responsible for the synthesis of endogenous QA. Quinolinic Acid 134-136 3-hydroxyanthranilate 3,4-dioxygenase Rattus norvegicus 82-87 11715084-11 2001 Comparison with earlier biochemical and immunohistochemical studies suggests that the enzyme responsible for microglial QUIN production is a distinct 3-hydroxyanthranilate oxygenase with high capacity and low affinity for 3HANA. Quinolinic Acid 120-124 3-hydroxyanthranilate 3,4-dioxygenase Rattus norvegicus 150-181