PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2952905-1 1987 Quinolinic acid (QUIN), a well-known excitotoxin, was found to inhibit type B monoamine oxidase (MAO-B) in human brain synaptosomal mitochondria. Quinolinic Acid 0-15 monoamine oxidase B Homo sapiens 97-102 2952905-1 1987 Quinolinic acid (QUIN), a well-known excitotoxin, was found to inhibit type B monoamine oxidase (MAO-B) in human brain synaptosomal mitochondria. Quinolinic Acid 17-21 monoamine oxidase B Homo sapiens 97-102 2952905-2 1987 By kinetic analysis, the inhibition of MAO-B activity by QUIN was competitive with the substrate, kynuramine. Quinolinic Acid 57-61 monoamine oxidase B Homo sapiens 39-44 2952905-4 1987 The selective inhibition of MAO-B by QUIN was confirmed using human liver mitochondria; only MAO-B was inhibited by QUIN and MAO-A was not inhibited. Quinolinic Acid 37-41 monoamine oxidase B Homo sapiens 28-33 2952905-4 1987 The selective inhibition of MAO-B by QUIN was confirmed using human liver mitochondria; only MAO-B was inhibited by QUIN and MAO-A was not inhibited. Quinolinic Acid 116-120 monoamine oxidase B Homo sapiens 93-98 2952905-6 1987 Among compounds structurally related to QUIN, 4-pyrimidine carboxaldehyde was the most potent substrate-competitive inhibitor of MAO-B, while 3-hydroxyanthranilic acid and xanthrenic acid, other metabolites of tryptophan, inhibited MAO non-competitively with the substrate. Quinolinic Acid 40-44 monoamine oxidase B Homo sapiens 129-134 2952905-7 1987 The inhibition of MAO-B by QUIN may be related to the causes of the neurotoxicity of QUIN. Quinolinic Acid 27-31 monoamine oxidase B Homo sapiens 18-23 2952905-7 1987 The inhibition of MAO-B by QUIN may be related to the causes of the neurotoxicity of QUIN. Quinolinic Acid 85-89 monoamine oxidase B Homo sapiens 18-23