PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27540379-8 2016 Similar to microglia and macrophages, these cells are highly responsive to IFN-gamma, which upregulates the expression of enzymes, including IDO-1, producing neurotoxic KP metabolites such as quinolinic acid. Quinolinic Acid 192-207 interferon gamma Homo sapiens 75-84 10834318-3 2000 IFN-gamma stimulates the enzyme indoleamine (2,3)-dioxygenase (IDO) converting tryptophan to the metabolite kynurenine which in macrophages is subsequently degraded to other, partly neurotoxic compounds like quinolinic acid, and finally to nicrotinamides. Quinolinic Acid 208-223 interferon gamma Homo sapiens 0-9 22084597-2 2010 It is proposed that stress induced interleukin-18 (IL-18), via interferon-gamma (IFNy) and independently, increases indoleamine 2,3-dioxygenase (IDO) and subsequent quinolinic acid (QA) in microglia. Quinolinic Acid 165-180 interferon gamma Homo sapiens 63-79 22084597-2 2010 It is proposed that stress induced interleukin-18 (IL-18), via interferon-gamma (IFNy) and independently, increases indoleamine 2,3-dioxygenase (IDO) and subsequent quinolinic acid (QA) in microglia. Quinolinic Acid 182-184 interferon gamma Homo sapiens 63-79 18063923-10 2007 Following inflammation-induced IDO activation, some TRYCATs, i.e. kynurenine, kynurenic acid, and xanthurenic acid, exert a negative feedback control over IFNgamma production thus downregulating the initial inflammation, whereas an excess of quinolinic acid further aggravates the initial inflammation. Quinolinic Acid 242-257 interferon gamma Homo sapiens 155-163 9871640-2 1998 The most potent of these, 2-amino-5-methyl-S-phenyl cysteine S,S-dioxide 6d, inhibits interferon-gamma induced synthesis of quinolinic acid in human macrophages. Quinolinic Acid 124-139 interferon gamma Homo sapiens 86-102 10204571-4 1999 In normal human macrophage cultures, IFN-gamma was the most potent stimulus for QUIN formation. Quinolinic Acid 80-84 interferon gamma Homo sapiens 37-46 9355959-0 1997 Quinolinic acid production by macrophages stimulated with IFN-gamma, TNF-alpha, and IFN-alpha. Quinolinic Acid 0-15 interferon gamma Homo sapiens 58-67 9355959-2 1997 Recent studies suggest that activation of macrophages with either HIV-1 or interferon-gamma (IFN-gamma) can lead to QUIN production. Quinolinic Acid 116-120 interferon gamma Homo sapiens 93-102 9355959-7 1997 Results at 72 h showed significant increases in QUIN production in the cells stimulated with IFN-gamma (10297 +/- 170 nmol/L) and also in those stimulated with IFN-alpha (3600 +/- 113 nmol/L), whereas TNF-alpha-stimulated macrophages produced low levels of QUIN (1108 +/- 23 nmol/L). Quinolinic Acid 48-52 interferon gamma Homo sapiens 93-102 9355959-7 1997 Results at 72 h showed significant increases in QUIN production in the cells stimulated with IFN-gamma (10297 +/- 170 nmol/L) and also in those stimulated with IFN-alpha (3600 +/- 113 nmol/L), whereas TNF-alpha-stimulated macrophages produced low levels of QUIN (1108 +/- 23 nmol/L). Quinolinic Acid 257-261 interferon gamma Homo sapiens 93-102 9355959-8 1997 Macrophages stimulated with the cytokine combinations TNF-alpha and IFN-gamma, IFN-alpha, and IFN-gamma, and TNF-alpha and IFN-alpha also resulted in increases in QUIN production (11471 +/- 77.6 nmol/L, 16656 +/- 184 nmol/L, and 3369 +/- 120.5 nmol/L, respectively). Quinolinic Acid 163-167 interferon gamma Homo sapiens 68-77 9355959-8 1997 Macrophages stimulated with the cytokine combinations TNF-alpha and IFN-gamma, IFN-alpha, and IFN-gamma, and TNF-alpha and IFN-alpha also resulted in increases in QUIN production (11471 +/- 77.6 nmol/L, 16656 +/- 184 nmol/L, and 3369 +/- 120.5 nmol/L, respectively). Quinolinic Acid 163-167 interferon gamma Homo sapiens 94-103 9080423-2 1997 Microglia and macrophages significantly increased quinolinic acid synthesis from tryptophan following activation by either lipopolysaccharide or interferon-gamma. Quinolinic Acid 50-65 interferon gamma Homo sapiens 145-161 9291104-5 1997 High activities of kynurenine 3-hydroxylase, kynureninase or 3-hydroxyanthranilate 3,4-dioxygenase were found in interferon-gamma-stimulated macrophages, THP-1 cells and SKHEP1 cells, and these cells made large amounts of quinolinate when supplied with L-tryptophan, L-kynurenine, 3-hydroxykynurenine or 3-hydroxyanthranilate. Quinolinic Acid 222-233 interferon gamma Homo sapiens 113-129 7474452-6 1995 Conversion of L-tryptophan to QUIN has also been demonstrated in vitro in both brain tissue following macrophage infiltration, and in macrophages stimulated by interferon-gamma or HIV infection. Quinolinic Acid 30-34 interferon gamma Homo sapiens 160-176 8643683-2 1996 Quin immunoreactivity (Quin-IR) was increased in gamma interferon (IFN-gamma)-stimulated monocytes/macrophages (MOs). Quinolinic Acid 0-4 interferon gamma Homo sapiens 49-76 7474452-7 1995 Macrophages in vitro have a high capacity to synthesize QUIN following exposure to interferon-gamma, tumor necrosis factor-alpha, IL-1 beta and IL-6, compared to cells derived from other tissues. Quinolinic Acid 56-60 interferon gamma Homo sapiens 83-128 7999315-8 1994 In addition, interferon-gamma (IFN-gamma) stimulation of macrophages induces release of the glutamate-like agonist, quinolinate. Quinolinic Acid 116-127 interferon gamma Homo sapiens 13-29 7847672-10 1994 In addition, gamma interferon (IFN-gamma) stimulation of macrophages induce release of the glutamate-like agonist quinolinate. Quinolinic Acid 114-125 interferon gamma Homo sapiens 13-40 7999315-8 1994 In addition, interferon-gamma (IFN-gamma) stimulation of macrophages induces release of the glutamate-like agonist, quinolinate. Quinolinic Acid 116-127 interferon gamma Homo sapiens 31-40 1465184-2 1992 Clinical studies have established that sustained elevations of quinolinic acid, L-kynurenine and kynurenic acid within the cerebrospinal fluid occur in patients with a broad spectrum of inflammatory diseases and correlate with markers of immune activation and interferon-gamma activity. Quinolinic Acid 63-78 interferon gamma Homo sapiens 260-276 8471029-0 1993 4-Chloro-3-hydroxyanthranilate, 6-chlorotryptophan and norharmane attenuate quinolinic acid formation by interferon-gamma-stimulated monocytes (THP-1 cells). Quinolinic Acid 76-91 interferon gamma Homo sapiens 105-121 1534219-8 1992 Macrophages stimulated with interferon-gamma may be an important source of accelerated L-tryptophan conversion into QUIN in inflammatory diseases. Quinolinic Acid 116-120 interferon gamma Homo sapiens 28-44