PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17081696-3	2007	QUIN injection induced a decrease in dopamine- and cyclic AMP-regulated phosphoprotein of 32 kDa (DARPP-32) protein levels that was higher in NT-3 +/- than in BDNF+/- or wild type animals.	Quinolinic Acid	0-4	brain derived neurotrophic factor	Mus musculus	159-163	
20463759-5	2010	However, intrastriatal administration of quinolinate increased the number of reactive astrocytes and enhanced the release of BDNF in pGFAP-BDNF mice compared with wild-type mice.	Quinolinic Acid	41-52	brain derived neurotrophic factor	Mus musculus	125-129	
20463759-5	2010	However, intrastriatal administration of quinolinate increased the number of reactive astrocytes and enhanced the release of BDNF in pGFAP-BDNF mice compared with wild-type mice.	Quinolinic Acid	41-52	brain derived neurotrophic factor	Mus musculus	139-143	
20463759-6	2010	Coincidentally, pGFAP-BDNF mice are more resistant to quinolinate than wild-type mice, suggesting a protective effect of astrocyte-derived BDNF.	Quinolinic Acid	54-65	brain derived neurotrophic factor	Mus musculus	22-26	
20463759-9	2010	However, pGFAP-BDNF-derived astrocytes showed higher levels of BDNF and larger neuroprotective effects than the wild-type ones when quinolinate was injected 30 days after grafting.	Quinolinic Acid	132-143	brain derived neurotrophic factor	Mus musculus	15-19	
20463759-10	2010	Interestingly, mice grafted with pGFAP-BDNF astrocytes showed important and sustained behavioral improvements over time after quinolinate administration as compared with mice grafted with wild-type astrocytes.	Quinolinic Acid	126-137	brain derived neurotrophic factor	Mus musculus	39-43	
23712629-7	2013	Acute intraventricular delivery of X5050 increased the expressions of BDNF and several other REST-regulated genes in the prefrontal cortex of mice with quinolinate-induced striatal lesions.	Quinolinic Acid	152-163	brain derived neurotrophic factor	Mus musculus	70-74	
18063376-2	2008	We found that R6/1:BDNF(+/-) mice--which express reduced levels of BDNF--were more resistant than R6/1 mice to intrastriatal injection of quinolinate.	Quinolinic Acid	138-149	brain derived neurotrophic factor	Mus musculus	19-23	
18063376-2	2008	We found that R6/1:BDNF(+/-) mice--which express reduced levels of BDNF--were more resistant than R6/1 mice to intrastriatal injection of quinolinate.	Quinolinic Acid	138-149	brain derived neurotrophic factor	Mus musculus	67-71	
17081696-2	2007	In the present study, intrastriatal injection of the N-methyl-d-aspartate receptor (NMDAR) agonist quinolinate (QUIN) was performed in mice heterozygous for neurotrophin-3 (NT3 +/-) or brain-derived neurotrophic factor (BDNF +/-) to analyze the role of endogenous neurotrophins on the regulation of striatal neurons susceptibility to excitotoxic injury.	Quinolinic Acid	99-110	brain derived neurotrophic factor	Mus musculus	185-218	
17081696-2	2007	In the present study, intrastriatal injection of the N-methyl-d-aspartate receptor (NMDAR) agonist quinolinate (QUIN) was performed in mice heterozygous for neurotrophin-3 (NT3 +/-) or brain-derived neurotrophic factor (BDNF +/-) to analyze the role of endogenous neurotrophins on the regulation of striatal neurons susceptibility to excitotoxic injury.	Quinolinic Acid	99-110	brain derived neurotrophic factor	Mus musculus	220-224	
35377087-3	2022	This pathway indicates that, chronic stress primarily promotes the release of excessive cortisol from the adrenal gland, which tends to activate microglia and further increases kynurenine and its downstream pathway, resulting in excessive quinolinic acid (QA), which further impairs brain derived neurotrophic factor (BDNF) levels and leads to neurodegeneration.	Quinolinic Acid	239-254	brain derived neurotrophic factor	Mus musculus	283-316	
35377087-3	2022	This pathway indicates that, chronic stress primarily promotes the release of excessive cortisol from the adrenal gland, which tends to activate microglia and further increases kynurenine and its downstream pathway, resulting in excessive quinolinic acid (QA), which further impairs brain derived neurotrophic factor (BDNF) levels and leads to neurodegeneration.	Quinolinic Acid	239-254	brain derived neurotrophic factor	Mus musculus	318-322	
35377087-3	2022	This pathway indicates that, chronic stress primarily promotes the release of excessive cortisol from the adrenal gland, which tends to activate microglia and further increases kynurenine and its downstream pathway, resulting in excessive quinolinic acid (QA), which further impairs brain derived neurotrophic factor (BDNF) levels and leads to neurodegeneration.	Quinolinic Acid	256-258	brain derived neurotrophic factor	Mus musculus	283-316	
35377087-3	2022	This pathway indicates that, chronic stress primarily promotes the release of excessive cortisol from the adrenal gland, which tends to activate microglia and further increases kynurenine and its downstream pathway, resulting in excessive quinolinic acid (QA), which further impairs brain derived neurotrophic factor (BDNF) levels and leads to neurodegeneration.	Quinolinic Acid	256-258	brain derived neurotrophic factor	Mus musculus	318-322