PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18844254-6	2009	Mangifera indica L. and Thalassia testudinum extracts, two natural polyphenol-rich extracts, diminished CYP1A1/2 and 3A4 activities, but not the CYP2D6 activity.	Polyphenols	67-77	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	104-110	
20883830-0	2011	Inhibition of 17beta-estradiol activation by CYP1A1: genotype- and regioselective inhibition by St. John"s Wort and several natural polyphenols.	Polyphenols	132-143	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	45-51	
20883830-9	2011	The data suggest that risk of estrogen-mediated diseases might be not only influenced by CYP1A1 genotype-dependent activation but also its inhibition by natural polyphenols of our diet and drugs.	Polyphenols	161-172	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	89-95	
17560072-0	2007	Developing a high-throughput system for the screening of cytochrome P450 1A1--inhibitory polyphenols.	Polyphenols	89-100	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	57-76	
12670496-0	2003	In vitro assessment of inhibition by natural polyphenols of metabolic activation of procarcinogens by human CYP1A1.	Polyphenols	45-56	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	108-114	
15661813-1	2005	The objective of this study was to examine the ability of dietary polyphenols to inhibit cytochrome P450 (CYP) 1A1 expression and activity and benzo[a]pyrene (BaP) DNA binding, with the main emphasis on prevention of chemical-induced hepatic carcinogenesis.	Polyphenols	66-77	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	89-114	
15661813-5	2005	Second, we screened 25 polyphenols with highly varying chemical structures for maximum ability to inhibit CYP1A1 activity in the Hep G2 cells.	Polyphenols	23-34	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	106-112	
17177569-0	2006	Cytochrome P450 1A1 expression and activity in Caco-2 cells: modulation by apple juice extract and certain apple polyphenols.	Polyphenols	113-124	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-19	
16484233-10	2006	Most importantly, western blotting showed all three polyphenols dramatically reducing BaP-induced CYP1A1 protein expression.	Polyphenols	52-63	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	98-104	
12670496-3	2003	We compared the effects of 11 representative natural polyphenols, which normally occur in food, on different activities of CYP1A1, namely epoxidation of 7,8-dihydrodiol-benzo[a]pyrene, the terminal step in the activation leading to the ultimate carcinogenic diolepoxides, hydroxylation of benzo[a]pyrene, and EROD.	Polyphenols	53-64	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	123-129	
12670496-5	2003	The results demonstrate that the inhibitory effects of dietary polyphenols on CYP1A1 activity depend on both the structure of the inhibitor and the type of the reaction and substrate used in the assay.	Polyphenols	63-74	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	78-84	
11754570-0	2002	Black tea polyphenols, theaflavins, prevent cellular DNA damage by inhibiting oxidative stress and suppressing cytochrome P450 1A1 in cell cultures.	Polyphenols	10-21	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	111-130	
23411228-5	2013	Moreover, these polyphenols up-regulated xenobiotic metabolizing enzymes UGT1A10 and CYP1A1, enhancing carcinogen detoxification.	Polyphenols	16-27	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	85-91	
22867086-3	2012	Using recombinant human enzyme, we confirmed earlier reported inhibitory effects of the polyphenols on cytochrome P4501A1 (CYP1A1) activity, and inhibition of metabolic clearance of FICZ was documented in FICZ-treated immortalized human keratinocytes (HaCaT).	Polyphenols	88-99	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	103-121	
22867086-3	2012	Using recombinant human enzyme, we confirmed earlier reported inhibitory effects of the polyphenols on cytochrome P4501A1 (CYP1A1) activity, and inhibition of metabolic clearance of FICZ was documented in FICZ-treated immortalized human keratinocytes (HaCaT).	Polyphenols	88-99	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	123-129