PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22743590-3	2012	In primary screening this semisynthetic halogenated polyphenol was identified to inhibit the activities of kinases ZAP-70 and Lck (IC50 0.34 microM and 16 microM, respectively), as well as hydrolase DPPIV (at 80 microM 41% inhibition).	Polyphenols	52-62	dipeptidyl peptidase 4	Homo sapiens	199-204	
34652225-0	2021	Advance in dietary polyphenols as dipeptidyl peptidase-IV inhibitors to alleviate type 2 diabetes mellitus: aspects from structure-activity relationship and characterization methods.	Polyphenols	19-30	dipeptidyl peptidase 4	Homo sapiens	34-57	
34652225-2	2021	Dietary polyphenols have attracted attention as dipeptidyl peptidase-IV (DPP-IV) inhibitors and indirectly improve insulin secretion.	Polyphenols	8-19	dipeptidyl peptidase 4	Homo sapiens	48-71	
34652225-2	2021	Dietary polyphenols have attracted attention as dipeptidyl peptidase-IV (DPP-IV) inhibitors and indirectly improve insulin secretion.	Polyphenols	8-19	dipeptidyl peptidase 4	Homo sapiens	73-79	
34652225-3	2021	The DPP-IV inhibitory activities of dietary polyphenols depend on their structural diversity.	Polyphenols	44-55	dipeptidyl peptidase 4	Homo sapiens	4-10	
34652225-4	2021	Screening methods that can be used to rapidly and accurately identify potential polyphenol DPP-IV inhibitors are urgently needed.	Polyphenols	80-90	dipeptidyl peptidase 4	Homo sapiens	91-97	
34652225-5	2021	This review focuses on the relationship between the structures of dietary polyphenols and their DPP-IV inhibitory effects.	Polyphenols	74-85	dipeptidyl peptidase 4	Homo sapiens	96-102	
34652225-6	2021	Different characterization methods used for polyphenols as DPP-IV inhibitors have been summarized and compared.	Polyphenols	44-55	dipeptidyl peptidase 4	Homo sapiens	59-65	
34652225-8	2021	Various combinations of methods, such as in-vitro enzymatic inhibition, ex-vivo/in-vivo enzymatic inhibition, cell-based in situ, and in-silico virtual screening, are used to evaluate the DPP-IV inhibitory effects of dietary polyphenols.	Polyphenols	225-236	dipeptidyl peptidase 4	Homo sapiens	188-194	
28556815-6	2017	The evidence suggests that polyphenols from various sources stimulate L-cells to secrete GLP1, increase its half-life by inhibiting dipeptidyl peptidase-4 (DPP4), stimulate beta-cells to secrete insulin and stimulate the peripheral response to insulin, increasing the overall effects of the GLP1-insulin axis.	Polyphenols	27-38	dipeptidyl peptidase 4	Homo sapiens	132-154	
28556815-6	2017	The evidence suggests that polyphenols from various sources stimulate L-cells to secrete GLP1, increase its half-life by inhibiting dipeptidyl peptidase-4 (DPP4), stimulate beta-cells to secrete insulin and stimulate the peripheral response to insulin, increasing the overall effects of the GLP1-insulin axis.	Polyphenols	27-38	dipeptidyl peptidase 4	Homo sapiens	156-160	
29882783-4	2018	This study describes the development of field template, field-based qualitative structure-activity relationship (SAR) model demonstrating DPP-4 inhibitors of natural origin, and the same model is used to screen virtually focused food database composed of polyphenols as potential DPP-4 inhibitors.	Polyphenols	255-266	dipeptidyl peptidase 4	Homo sapiens	280-285