PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23275086-3	2013	We hypotheses that PTEN gene could affect the growth and viability of ASMCs through the regulation of PI3K/Akt, MAPK, and cell cycle-related gene expression.	asmcs	70-75	AKT serine/threonine kinase 1	Homo sapiens	107-110	
31435973-8	2019	Furthermore, PDGF-caused activation of PI3K/Akt pathway in ASMCs was inhibited by esculetin.	asmcs	59-64	AKT serine/threonine kinase 1	Homo sapiens	44-47	
16721826-10	2006	The effects of etoposide and paclitaxel on Akt also differed between ASMCs and VSMCs.	asmcs	69-74	AKT serine/threonine kinase 1	Homo sapiens	43-46	
32495835-12	2020	In conclusion, these findings showed that Gal-1 exerted inhibitory effects on PDGF-BB-stimulated proliferation, migration and phenotype switching of ASMCs via inhibiting the PI3K/Akt signaling pathway.	asmcs	149-154	AKT serine/threonine kinase 1	Homo sapiens	179-182	
30528236-9	2019	Finally, both TIMMDC1 overexpression and AKT activator could restored the inhibitory impacts of lncTCF7 silence on PDGF-BB treated ASMCs.	asmcs	131-136	AKT serine/threonine kinase 1	Homo sapiens	41-44	
29207148-7	2018	Furthermore, pretreatment with PF reduced PDGF-BB-induced phosphorylation of phosphoinositide 3-kinase (PI3K) and AKT serine/threonine kinase 1 (Akt) in ASMCs.	asmcs	153-158	AKT serine/threonine kinase 1	Homo sapiens	145-148	
29636864-11	2018	Finally, we showed that miR-223 suppressed IGF-1R expression and decreased downstream phosphorylation of Akt (AKT1) in ASMCs.	asmcs	119-124	AKT serine/threonine kinase 1	Homo sapiens	105-108	
29636864-11	2018	Finally, we showed that miR-223 suppressed IGF-1R expression and decreased downstream phosphorylation of Akt (AKT1) in ASMCs.	asmcs	119-124	AKT serine/threonine kinase 1	Homo sapiens	110-114	
29636864-12	2018	In conclusion, our data demonstrate that miR-223 exerts an inhibitory effect on the fibrotic phenotypes of ASMCs via the PI3K/Akt signaling pathway and IGF-1R is the likely functional target of the microRNA.	asmcs	107-112	AKT serine/threonine kinase 1	Homo sapiens	126-129	
27600020-2	2016	Platelet derived growth factor (PDGF) activated phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling pathway, and this in turn up-regulated S-phase kinase-associated protein 2 (Skp2) and consequently reduced cyclin dependent kinase inhibitor 1B (p27) leading to ASMCs proliferation.	asmcs	316-321	AKT serine/threonine kinase 1	Homo sapiens	103-106	
26761017-8	2016	Taken together, oligo-fucoidan supplementation might reduce proliferation of PDGF-treated ASMCs through the suppression of ERK1/2 and Akt phosphorylation and NF-kappaB activation.	asmcs	90-95	AKT serine/threonine kinase 1	Homo sapiens	134-137	
27649066-12	2017	Cytokines IL-4, IL-5, TNF-alpha, and TGF-beta1, and serum from patients with asthma increased collagen-I synthesis, cell proliferation, and phosphorylation of Akt in ASMCs, which were blocked by the calpain inhibitor MDL28170.	asmcs	166-171	AKT serine/threonine kinase 1	Homo sapiens	159-162