PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23275086-3 2013 We hypotheses that PTEN gene could affect the growth and viability of ASMCs through the regulation of PI3K/Akt, MAPK, and cell cycle-related gene expression. asmcs 70-75 mitogen-activated protein kinase 3 Homo sapiens 112-116 29665364-6 2018 Furthermore, casticin significantly prevented the activation of ERK1/2 and NF-kappaB pathways in PDGF-stimulated ASMCs. asmcs 113-118 mitogen-activated protein kinase 3 Homo sapiens 64-70 28851074-6 2018 In conclusion, this study demonstrated that MIF overexpression promotes the proliferation and migration of ASMCs by upregulating the activity of the ERK1/2 and FAK signaling pathways in these cells, further indicating that inhibition of MIF may prove to be an effective strategy for treating asthma patients with airway remodeling. asmcs 107-112 mitogen-activated protein kinase 3 Homo sapiens 149-155 28081849-9 2017 PDGF-BB significantly increased PRMT1 expression through ERK1/2 MAPK and STAT1 signaling in control ASMCs, whereas in ASMCs from asthmatic patients, these proteins were constitutively expressed. asmcs 100-105 mitogen-activated protein kinase 3 Homo sapiens 57-63 28081849-10 2017 ASMCs from asthmatic patients had reduced miR-19a expression, causing upregulation of ERK1/2 MAPK, STAT1, and PRMT1. asmcs 0-5 mitogen-activated protein kinase 3 Homo sapiens 86-92 26761017-8 2016 Taken together, oligo-fucoidan supplementation might reduce proliferation of PDGF-treated ASMCs through the suppression of ERK1/2 and Akt phosphorylation and NF-kappaB activation. asmcs 90-95 mitogen-activated protein kinase 3 Homo sapiens 123-129 25955575-9 2015 In conclusion, these results indicate that Ang II can induce MMP-2 expression elevation through AT1R and MAPK pathways in ASMCs and suggest that there is therapeutic potential for angiotensin receptor blocker drugs and MAPK inhibitors in the prevention and treatment of ATAAs. asmcs 122-127 mitogen-activated protein kinase 3 Homo sapiens 105-109 25955575-9 2015 In conclusion, these results indicate that Ang II can induce MMP-2 expression elevation through AT1R and MAPK pathways in ASMCs and suggest that there is therapeutic potential for angiotensin receptor blocker drugs and MAPK inhibitors in the prevention and treatment of ATAAs. asmcs 122-127 mitogen-activated protein kinase 3 Homo sapiens 219-223 22898922-5 2012 IL-17A and IL-17F-induced proliferation of ASMCs was dependent on ERK1/2 MAPK pathway, while IL-22-induced proliferation involved both ERK1/2 MAPK and NF-kappaB pathways. asmcs 43-48 mitogen-activated protein kinase 3 Homo sapiens 66-72 22898922-5 2012 IL-17A and IL-17F-induced proliferation of ASMCs was dependent on ERK1/2 MAPK pathway, while IL-22-induced proliferation involved both ERK1/2 MAPK and NF-kappaB pathways. asmcs 43-48 mitogen-activated protein kinase 3 Homo sapiens 73-77 21903578-11 2011 We identify that Egr1 (early growth responsive protein-1) activates miR-26a promoter via enhanced phosphorylation of Erk1/2 in ASMCs(Des-/-). asmcs 127-132 mitogen-activated protein kinase 3 Homo sapiens 117-123 21903578-13 2011 Moreover, induction of ASMCs(Des-/-) hypertrophy by the Erk-1/2/Egr-1/miR-26a/GSK-3beta pathway is consistent in human recombinant ASMCs, which stably suppresses 90% endogenous desmin expression. asmcs 23-28 mitogen-activated protein kinase 3 Homo sapiens 56-63 21903578-13 2011 Moreover, induction of ASMCs(Des-/-) hypertrophy by the Erk-1/2/Egr-1/miR-26a/GSK-3beta pathway is consistent in human recombinant ASMCs, which stably suppresses 90% endogenous desmin expression. asmcs 131-136 mitogen-activated protein kinase 3 Homo sapiens 56-63 21493783-8 2011 Moreover, suppressing ERK1/ERK2 activation prevented neutrophil recruitment by ASMCs, whereas suppressing p38 MAPK activity had no impact. asmcs 79-84 mitogen-activated protein kinase 3 Homo sapiens 22-26