PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12697024-1 2003 Glycine N-methyltransferase (GNMT) is an abundant cytosolic enzyme that catalyses the methylation of glycine into sarcosine, coupled with conversion of the methyl donor, S -adenosylmethionine (AdoMet), into S -adenosylhomocysteine (AdoHcy). S-Adenosylhomocysteine 207-230 glycine N-methyltransferase Homo sapiens 0-27 12859184-3 2003 Unlike most SAM-dependent methyltransferases, GNMT has a relatively high value and is weakly inhibited by the product S-adenosyl-l-homocysteine (SAH). S-Adenosylhomocysteine 118-143 glycine N-methyltransferase Homo sapiens 46-50 12697024-1 2003 Glycine N-methyltransferase (GNMT) is an abundant cytosolic enzyme that catalyses the methylation of glycine into sarcosine, coupled with conversion of the methyl donor, S -adenosylmethionine (AdoMet), into S -adenosylhomocysteine (AdoHcy). S-Adenosylhomocysteine 207-230 glycine N-methyltransferase Homo sapiens 29-33 12697024-1 2003 Glycine N-methyltransferase (GNMT) is an abundant cytosolic enzyme that catalyses the methylation of glycine into sarcosine, coupled with conversion of the methyl donor, S -adenosylmethionine (AdoMet), into S -adenosylhomocysteine (AdoHcy). S-Adenosylhomocysteine 232-238 glycine N-methyltransferase Homo sapiens 0-27 12697024-1 2003 Glycine N-methyltransferase (GNMT) is an abundant cytosolic enzyme that catalyses the methylation of glycine into sarcosine, coupled with conversion of the methyl donor, S -adenosylmethionine (AdoMet), into S -adenosylhomocysteine (AdoHcy). S-Adenosylhomocysteine 232-238 glycine N-methyltransferase Homo sapiens 29-33 1332963-1 1992 Glycine N-methyltransferase (GNMT) regulates the ratio of S-adenosylmethionine to S-adenosylhomocysteine. S-Adenosylhomocysteine 82-104 glycine N-methyltransferase Homo sapiens 0-27 10843803-1 2000 The glycine N-methyltransferase (GNMT) gene encodes a protein that not only acts as an enzyme to regulate the ratio of S-adenosylmethionine to S-adenosylhomocysteine, but also participates in the detoxification pathway in liver cells. S-Adenosylhomocysteine 143-165 glycine N-methyltransferase Homo sapiens 4-31 10843803-1 2000 The glycine N-methyltransferase (GNMT) gene encodes a protein that not only acts as an enzyme to regulate the ratio of S-adenosylmethionine to S-adenosylhomocysteine, but also participates in the detoxification pathway in liver cells. S-Adenosylhomocysteine 143-165 glycine N-methyltransferase Homo sapiens 33-37 9655336-2 1998 GNMT is a tetrameric enzyme (monomer Mr = 32,423Da, 292 amino acids) that catalyzes the transfer of a methyl group from S-adenosylmethionine (AdoMet) to glycine with the formation of S-adenosylhomocysteine (AdoHcy) and sarcosine (N-methylglycine). S-Adenosylhomocysteine 183-205 glycine N-methyltransferase Homo sapiens 0-4 9655336-2 1998 GNMT is a tetrameric enzyme (monomer Mr = 32,423Da, 292 amino acids) that catalyzes the transfer of a methyl group from S-adenosylmethionine (AdoMet) to glycine with the formation of S-adenosylhomocysteine (AdoHcy) and sarcosine (N-methylglycine). S-Adenosylhomocysteine 207-213 glycine N-methyltransferase Homo sapiens 0-4 11810299-6 2002 The function of GNMT has been hypothesized to provide an alternative route for the conversion of excess AdoMet to AdoHcy in order to preserve the AdoMet/AdoHcy ratio. S-Adenosylhomocysteine 114-120 glycine N-methyltransferase Homo sapiens 16-20 11810299-6 2002 The function of GNMT has been hypothesized to provide an alternative route for the conversion of excess AdoMet to AdoHcy in order to preserve the AdoMet/AdoHcy ratio. S-Adenosylhomocysteine 153-159 glycine N-methyltransferase Homo sapiens 16-20 10756111-0 2000 Mechanisms for auto-inhibition and forced product release in glycine N-methyltransferase: crystal structures of wild-type, mutant R175K and S-adenosylhomocysteine-bound R175K enzymes. S-Adenosylhomocysteine 140-162 glycine N-methyltransferase Homo sapiens 61-88 1332963-1 1992 Glycine N-methyltransferase (GNMT) regulates the ratio of S-adenosylmethionine to S-adenosylhomocysteine. S-Adenosylhomocysteine 82-104 glycine N-methyltransferase Homo sapiens 29-33 23936142-1 2013 Glycine N-methyltransferase (GNMT), an abundant cytosolic enzyme, catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to glycine generating S-adenosylhomocysteine and sarcosine (N-methylglycine). S-Adenosylhomocysteine 161-183 glycine N-methyltransferase Homo sapiens 0-27 33241846-8 2020 Importantly, we found that GNMT, a multiple functional protein that regulates the cellular pool of methyl groups by controlling the ratio of S-adenosylmethionine (SAM) to S-adenosylhomocysteine (SAH), was down-regulated significantly in the serum of Type 1 DM patients and renal tissues of DN mice. S-Adenosylhomocysteine 171-193 glycine N-methyltransferase Homo sapiens 27-31 23475283-3 2013 SAMe levels depend on the glycine-N-methyltransferase (GNMT), a one-carbon group methyltransferase, which catalyzes the conversion of SAMe to S-adenosylhomocysteine in hepatic cells. S-Adenosylhomocysteine 142-164 glycine N-methyltransferase Homo sapiens 26-53 23475283-3 2013 SAMe levels depend on the glycine-N-methyltransferase (GNMT), a one-carbon group methyltransferase, which catalyzes the conversion of SAMe to S-adenosylhomocysteine in hepatic cells. S-Adenosylhomocysteine 142-164 glycine N-methyltransferase Homo sapiens 55-59 34065390-3 2021 Glycine N-methyltransferase (GNMT) further utilizes SAM for sarcosine formation, thus it regulates the ratio of SAM:S-adenosylhomocysteine (SAH). S-Adenosylhomocysteine 116-138 glycine N-methyltransferase Homo sapiens 0-27 34065390-3 2021 Glycine N-methyltransferase (GNMT) further utilizes SAM for sarcosine formation, thus it regulates the ratio of SAM:S-adenosylhomocysteine (SAH). S-Adenosylhomocysteine 116-138 glycine N-methyltransferase Homo sapiens 29-33 27355841-2 2016 Glycine N-methyltransferase (GNMT), a member of the family that acts on small metabolites as the substrate, catalyzes methyl transfer from S-adenosyl-l-methionine (AdoMet) to glycine to form S-adenosyl-l-homocysteine and sarcosine. S-Adenosylhomocysteine 191-216 glycine N-methyltransferase Homo sapiens 0-27 27355841-2 2016 Glycine N-methyltransferase (GNMT), a member of the family that acts on small metabolites as the substrate, catalyzes methyl transfer from S-adenosyl-l-methionine (AdoMet) to glycine to form S-adenosyl-l-homocysteine and sarcosine. S-Adenosylhomocysteine 191-216 glycine N-methyltransferase Homo sapiens 29-33 24800880-1 2014 PURPOSE: Glycine N-methyltransferase (GNMT) affects genetic stability by regulating the ratio of S-adenosylmethionine to S-adenosylhomocysteine, by binding to folate, and by interacting with environmental carcinogens. S-Adenosylhomocysteine 121-143 glycine N-methyltransferase Homo sapiens 9-36 24800880-1 2014 PURPOSE: Glycine N-methyltransferase (GNMT) affects genetic stability by regulating the ratio of S-adenosylmethionine to S-adenosylhomocysteine, by binding to folate, and by interacting with environmental carcinogens. S-Adenosylhomocysteine 121-143 glycine N-methyltransferase Homo sapiens 38-42 23936142-1 2013 Glycine N-methyltransferase (GNMT), an abundant cytosolic enzyme, catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to glycine generating S-adenosylhomocysteine and sarcosine (N-methylglycine). S-Adenosylhomocysteine 161-183 glycine N-methyltransferase Homo sapiens 29-33 23474979-5 2013 In addition, mutations in glycine-N-methyltransferase (GNMT) could be associated with a higher risk of hepatocellular carcinoma and liver disease due to an unbalanced S-adenosylmethionine (SAM)/S-adenosylhomocysteine (SAH) ratio, which leads to aberrant methylation reactions. S-Adenosylhomocysteine 196-216 glycine N-methyltransferase Homo sapiens 26-53 23474979-5 2013 In addition, mutations in glycine-N-methyltransferase (GNMT) could be associated with a higher risk of hepatocellular carcinoma and liver disease due to an unbalanced S-adenosylmethionine (SAM)/S-adenosylhomocysteine (SAH) ratio, which leads to aberrant methylation reactions. S-Adenosylhomocysteine 196-216 glycine N-methyltransferase Homo sapiens 55-59 21210071-1 2011 Glycine N-methyltransferase (GNMT) is a major hepatic enzyme that converts S-adenosylmethionine to S-adenosylhomocysteine while generating sarcosine from glycine, hence it can regulate mediating methyl group availability in mammalian cells. S-Adenosylhomocysteine 99-121 glycine N-methyltransferase Homo sapiens 0-27 21210071-1 2011 Glycine N-methyltransferase (GNMT) is a major hepatic enzyme that converts S-adenosylmethionine to S-adenosylhomocysteine while generating sarcosine from glycine, hence it can regulate mediating methyl group availability in mammalian cells. S-Adenosylhomocysteine 99-121 glycine N-methyltransferase Homo sapiens 29-33