PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35347108-5 2022 Osimertinib led to apoptosis of tumors but simultaneously, it triggered inositol-requiring-enzyme (IRE1alpha)-dependent HER3 upregulation, increased macrophage infiltration, and activated cGAS in cancer cells to produce cGAMP (detected by a lentivirally transduced STING activity biosensor), transactivating STING in macrophages. osimertinib 0-11 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 99-108 28730963-0 2018 Increased Expression of IRE1alpha Associates with the Resistant Mechanism of Osimertinib (AZD9291)-resistant non-small Cell Lung Cancer HCC827/OSIR Cells. osimertinib 90-97 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 24-33