PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32398685-7 2021 We further showed that osimertinib potently inhibited the MNK kinase activities with IC50 values of 324 nM and 48.6 nM, respectively, against MNK1 and MNK2 kinases; osimertinib (0.3-3 muM) dose-dependently suppressed the phosphorylation of eukaryotic translation initiation factor 4E (eIF4E). osimertinib 23-34 eukaryotic translation initiation factor 4E Homo sapiens 240-283 32398685-7 2021 We further showed that osimertinib potently inhibited the MNK kinase activities with IC50 values of 324 nM and 48.6 nM, respectively, against MNK1 and MNK2 kinases; osimertinib (0.3-3 muM) dose-dependently suppressed the phosphorylation of eukaryotic translation initiation factor 4E (eIF4E). osimertinib 23-34 eukaryotic translation initiation factor 4E Homo sapiens 285-290