PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31446643-5 2019 AZD9291 resistance was partially restored by combination of AZD9291 and crizotinib only in resistant cells overexpressing phospho-c-Met, which synergistically inhibited c-Met-mediated phosphorylation of the downstream targets ERK1/2 and AKT. osimertinib 0-7 mitogen-activated protein kinase 3 Homo sapiens 226-232 34077739-8 2021 In osimertinib resistant H1975 cells, the drug combination was less capable of inactivating AKT, mTOR, STAT3, STAT5, ERK1/2 whereas it gained the ability to inactivate ERBB3. osimertinib 3-14 mitogen-activated protein kinase 3 Homo sapiens 117-123 33511016-8 2021 The combination of CP@NP-cRGD and AZD9291 significantly induces a higher rate of apoptosis, more G0/G1 phase arrest, and reduces proliferation of resistant cell lines by downregulation of p-ERK1/2 in vitro. osimertinib 34-41 mitogen-activated protein kinase 3 Homo sapiens 190-196 31446643-5 2019 AZD9291 resistance was partially restored by combination of AZD9291 and crizotinib only in resistant cells overexpressing phospho-c-Met, which synergistically inhibited c-Met-mediated phosphorylation of the downstream targets ERK1/2 and AKT. osimertinib 60-67 mitogen-activated protein kinase 3 Homo sapiens 226-232