PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32678313-0 2021 TGFbeta2-mediated epithelial-mesenchymal transition and NF-kappaB pathway activation contribute to osimertinib resistance. osimertinib 99-110 transforming growth factor beta 2 Homo sapiens 0-8 32678313-5 2021 The EMT occurrence resulted from osimertinib-induced upregulation of TGFbeta2 that activated SMAD2. osimertinib 33-44 transforming growth factor beta 2 Homo sapiens 69-77 32678313-7 2021 In NCI-H1975 cells, osimertinib activated NF-kappaB pathway, evidenced by the increased p65 nuclear translocation, which was abolished by knockdown of TGFbeta2. osimertinib 20-31 transforming growth factor beta 2 Homo sapiens 151-159 32678313-10 2021 These findings shed new light on distinct roles of TGFbeta2 in osimertinib-resistant cells and provide new strategies for treatment of this resistant status. osimertinib 63-74 transforming growth factor beta 2 Homo sapiens 51-59