PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33193892-8 2020 Moreover, multivariate analysis indicated that BM status (P=0.015), local therapy for BM (P=0.013) and subsequent treatment of Osimertinib (P=0.008) impact significantly on OS. osimertinib 127-138 Moloney sarcoma oncogene Mus musculus 173-175 34457028-5 2021 Forty-four osimertinib-treated patients had an improved mOS of 13.15 (95% CI: 5.74-20.57) and a median progression-free survival (PFS) of 9.50 months (95% CI: 6.77-12.23) when compared with patients treated with first- or second-generation EGFR-TKI (mOS = 3.00 months (95% CI: 1.32-4.68) and median PFS = 1.50 months (95% CI: 0.00-3.14)). osimertinib 11-22 Moloney sarcoma oncogene Mus musculus 56-59 34457028-6 2021 In the osimertinib group, mOS values for CSF with and without T790M mutation were 22.15 months (95% CI: 9.44-34.87) and 13.39 months (95% CI: 7.01-19.76), respectively, with no statistical differences. osimertinib 7-18 Moloney sarcoma oncogene Mus musculus 26-29 32652216-2 2020 Current study explored whether treatment with osimertinib leads to improved overall survival (OS) for EGFR-mutated NSCLC patients with leptomeningeal metastases (LM) compared with those not treated with osimertinib. osimertinib 46-57 Moloney sarcoma oncogene Mus musculus 94-96 32652216-8 2020 However, patients treated with osimertinib showed a superior OS of 17.0 months (95% CI, 15.13-18.94) compared with those not treated with osimertinib who showed a mOS 5.5 months (95% CI 4.34-6.63) regardless of T790M mutational status (HR 0.36; 95% CI 0.28-0.47, P <0.001). osimertinib 31-42 Moloney sarcoma oncogene Mus musculus 61-63