PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20638753-5 2012 To investigate a functional link between the disorders diabetes and AD, the effect of 2 AGEs, pentosidine and glyceraldehydes-derived pyridinium (GLAP), was studied on BACE1 expression both in vivo, in streptozotocin treated rats, and in vitro in differentiated neuroblastoma cells. pentosidine 94-105 beta-secretase 1 Rattus norvegicus 168-173 20638753-6 2012 We showed that pentosidine and GLAP were able to upregulate BACE1 expression through their binding with RAGE and the consequent activation of NF-kappaB. pentosidine 15-26 beta-secretase 1 Rattus norvegicus 60-65