PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22430364-7 2012 The MDCKII-MRP2 and MDCKII-Bcrp1 cells significantly increased forsythiaside efflux ratio compared with the parental cells due to the apically directed transport by MRP2 and Bcrp1, respectively. forsythiaside 63-76 ATP binding cassette subfamily C member 2 Canis lupus familiaris 11-15 22430364-7 2012 The MDCKII-MRP2 and MDCKII-Bcrp1 cells significantly increased forsythiaside efflux ratio compared with the parental cells due to the apically directed transport by MRP2 and Bcrp1, respectively. forsythiaside 63-76 ATP binding cassette subfamily C member 2 Canis lupus familiaris 165-169 22430364-8 2012 The efflux ratios in MRP2 and Bcrp1 transfected cell lines were greatly decreased in the presence of MK-571 and Ko143, respectively, which indicated that forsythiaside efflux by MRP2 and Bcrp1 were significantly inhibited by their selective inhibitors. forsythiaside 154-167 ATP binding cassette subfamily C member 2 Canis lupus familiaris 21-25 22430364-8 2012 The efflux ratios in MRP2 and Bcrp1 transfected cell lines were greatly decreased in the presence of MK-571 and Ko143, respectively, which indicated that forsythiaside efflux by MRP2 and Bcrp1 were significantly inhibited by their selective inhibitors. forsythiaside 154-167 ATP binding cassette subfamily C member 2 Canis lupus familiaris 178-182 22430364-11 2012 This study presents direct evidence that forsythiaside is effluxed by both MRP2 and Bcrp1, which may contribute to its poor oral bioavailability. forsythiaside 41-54 ATP binding cassette subfamily C member 2 Canis lupus familiaris 75-79