PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33609514-6	2021	It was also observed an enantioselectivity in the binding to P-glycoprotein (P-gp), another efflux protein, being the R-(-)-pentedrone and S-(-)-methylone the most transported enantiomeric compounds.	methylone	139-154	ATP binding cassette subfamily B member 1	Homo sapiens	61-75	
33609514-6	2021	It was also observed an enantioselectivity in the binding to P-glycoprotein (P-gp), another efflux protein, being the R-(-)-pentedrone and S-(-)-methylone the most transported enantiomeric compounds.	methylone	139-154	ATP binding cassette subfamily B member 1	Homo sapiens	77-81	
33609514-7	2021	These results were confirmed, in silico, by docking studies, revealing that R-(-)-pentedrone is the enantiomer with highest affinity to MRP1 and S-(-)-methylone and R-(-)-pentedrone are the enantiomers with highest affinity to P-gp.	methylone	145-160	ATP binding cassette subfamily B member 1	Homo sapiens	227-231	
33609514-8	2021	In conclusion, our data demonstrated that pentedrone and methylone present enantioselectivity in their cytotoxicity, which seems to involve, different oxidative reactivity as well as different affinity to the P-gp and MRP1 that together with GSH, play a protective role.	methylone	57-66	ATP binding cassette subfamily B member 1	Homo sapiens	209-213