PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23545806-3	2013	Using in vitro studies, CYP2D6 was determined to be the primary enzyme that metabolizes methylone, with minor contributions from CYP1A2, CYP2B6, and CYP2C19.	methylone	88-97	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	24-30	
23545806-7	2013	Additionally, a time-dependent loss of CYP2D6 activity was observed when the enzyme was preincubated with methylone, reaching a maximum rate of inactivation at high methylone concentrations, indicating that methylone is a mechanism-based inhibitor of CYP2D6.	methylone	106-115	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	39-45	
23545806-7	2013	Additionally, a time-dependent loss of CYP2D6 activity was observed when the enzyme was preincubated with methylone, reaching a maximum rate of inactivation at high methylone concentrations, indicating that methylone is a mechanism-based inhibitor of CYP2D6.	methylone	106-115	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	251-257	
23545806-7	2013	Additionally, a time-dependent loss of CYP2D6 activity was observed when the enzyme was preincubated with methylone, reaching a maximum rate of inactivation at high methylone concentrations, indicating that methylone is a mechanism-based inhibitor of CYP2D6.	methylone	165-174	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	39-45	
23545806-7	2013	Additionally, a time-dependent loss of CYP2D6 activity was observed when the enzyme was preincubated with methylone, reaching a maximum rate of inactivation at high methylone concentrations, indicating that methylone is a mechanism-based inhibitor of CYP2D6.	methylone	165-174	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	251-257