PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23935713-3 2013 In a previous study, we demonstrated that sivelestat, a specific inhibitor of neutrophil elastase (NE), is effective in protecting against lung failure in rats with taurocholate-induced acute pancreatitis. sivelestat 42-52 elastase, neutrophil expressed Rattus norvegicus 78-97 27430552-0 2016 The neutrophil elastase inhibitor, sivelestat, attenuates sepsis-related kidney injury in rats. sivelestat 35-45 elastase, neutrophil expressed Rattus norvegicus 4-23 27430552-2 2016 Sivelestat, a selective inhibitor of neutrophil elastase (NE), can attenuate sepsis-related acute lung injury. sivelestat 0-10 elastase, neutrophil expressed Rattus norvegicus 37-56 27430552-2 2016 Sivelestat, a selective inhibitor of neutrophil elastase (NE), can attenuate sepsis-related acute lung injury. sivelestat 0-10 elastase, neutrophil expressed Rattus norvegicus 58-60 24785170-3 2014 In a previous study, we demonstrated that sivelestat, a specific inhibitor of neutrophil elastase, is effective in protecting against lung failure in rats with taurocholate-induced acute pancreatitis. sivelestat 42-52 elastase, neutrophil expressed Rattus norvegicus 78-97 23935713-3 2013 In a previous study, we demonstrated that sivelestat, a specific inhibitor of neutrophil elastase (NE), is effective in protecting against lung failure in rats with taurocholate-induced acute pancreatitis. sivelestat 42-52 elastase, neutrophil expressed Rattus norvegicus 99-101 23935713-7 2013 These observations strongly suggest that the NE inhibitor, sivelestat, is effective in protecting against acute pancreatitis-associated renal injury. sivelestat 59-69 elastase, neutrophil expressed Rattus norvegicus 45-47 23766850-1 2013 The neutrophil elastase inhibitor sivelestat (ONO-5046) possesses unknown mechanisms of cardioprotection when infused following global ischemia, even in the absence of neutrophils. sivelestat 34-44 elastase, neutrophil expressed Rattus norvegicus 4-23 22999209-3 2013 Our objective was to assess the role of NE, and effect of sivelestat, a specific NE inhibitor, in lung injury induced by burn-blast combined injury in rats. sivelestat 58-68 elastase, neutrophil expressed Rattus norvegicus 81-83 23766850-1 2013 The neutrophil elastase inhibitor sivelestat (ONO-5046) possesses unknown mechanisms of cardioprotection when infused following global ischemia, even in the absence of neutrophils. sivelestat 46-54 elastase, neutrophil expressed Rattus norvegicus 4-23 19279053-1 2009 Sivelestat, a neutrophil elastase inhibitor, has been shown to attenuate pulmonary injury during ischemia and reperfusion by improving microcirculation and may be effective as a cardioprotective agent. sivelestat 0-10 elastase, neutrophil expressed Rattus norvegicus 14-33 20575981-0 2011 Protective effect of sivelestat, a neutrophil elastase inhibitor, on ipsilateral and contralateral testes after unilateral testicular ischaemia-reperfusion injury in rats. sivelestat 21-31 elastase, neutrophil expressed Rattus norvegicus 35-54 19995276-3 2009 The authors hypothesized that synthetic neutrophil elastase inhibitor, sivelestat (ONO-5046), can inhibit the bleomycin-induced pulmonary fibrosis in rats by blocking the apoptotic pathways in epithelial cells. sivelestat 71-81 elastase, neutrophil expressed Rattus norvegicus 40-59 19995276-3 2009 The authors hypothesized that synthetic neutrophil elastase inhibitor, sivelestat (ONO-5046), can inhibit the bleomycin-induced pulmonary fibrosis in rats by blocking the apoptotic pathways in epithelial cells. sivelestat 83-91 elastase, neutrophil expressed Rattus norvegicus 40-59 19995276-14 2009 These findings suggest that sivelestat can suppress the bleomycin-induced pulmonary fibrosis by blocking neutrophil chemotaxis and by inhibiting the neutrophil elastase-induced lung cell apoptosis in rats. sivelestat 28-38 elastase, neutrophil expressed Rattus norvegicus 149-168 21221803-1 2011 BACKGROUND: Recent evidence has indicated that sivelestat, a neutrophil elastase inhibitor, has liver-protective effects in a variety of liver injuries. sivelestat 47-57 elastase, neutrophil expressed Rattus norvegicus 61-80 19482311-0 2009 Prevention of leukocyte activation by the neutrophil elastase inhibitor, sivelestat, in the hepatic microcirculation after ischemia-reperfusion. sivelestat 73-83 elastase, neutrophil expressed Rattus norvegicus 42-61 19168036-6 2009 Plasma neutrophil elastase activity in the ONO-5046 10 mg/kg group was significantly lower than in the control group (14 [11-25] vs. 41 [35-68] nmol/ml). sivelestat 43-51 elastase, neutrophil expressed Rattus norvegicus 7-26 19168036-7 2009 Neutrophil elastase distributed in the extracellular space in the hippocampal CA1 neuronal layer in the control group, while, in the ONO-5046 10 mg/kg group, trace of neutrophil elastase was detected only in the endothelium. sivelestat 133-141 elastase, neutrophil expressed Rattus norvegicus 167-186 18199098-2 2008 Sivelestat is a selective neutrophil elastase inhibitor used for acute lung injury associated with systemic inflammatory response syndrome. sivelestat 0-10 elastase, neutrophil expressed Rattus norvegicus 26-45 21479437-4 2008 We investigated the beneficial effect of neutrophil elastase inhibitor (ONO-5046.Na) on renal I/R injury in rats. sivelestat 72-80 elastase, neutrophil expressed Rattus norvegicus 41-60 21479437-14 2008 To conclude, ONO-5046.Na inhibits neutrophil elastase and reduces acute tubular necrosis. sivelestat 13-21 elastase, neutrophil expressed Rattus norvegicus 34-53 18536984-0 2008 A neutrophil elastase inhibitor, sivelestat, reduces lung injury following endotoxin-induced shock in rats by inhibiting HMGB1. sivelestat 33-43 elastase, neutrophil expressed Rattus norvegicus 2-21 17888675-2 2007 We hypothesized that the addition of sivelestat, a specific neutrophil elastase inhibitor, to the organ flushing solution would decrease reperfusion injury in a rat single left-lung transplant model. sivelestat 37-47 elastase, neutrophil expressed Rattus norvegicus 60-79 17315175-2 2007 This study investigated the possible mechanism underlying the protective effect of sivelestat, a neutrophil elastase inhibitor, on endotoxin-induced liver injury following partial hepatectomy. sivelestat 83-93 elastase, neutrophil expressed Rattus norvegicus 97-116 17024574-4 2006 ICAM-1 expression in the rat endothelial cell line (WK-5) was significantly upregulated after stimulation with neutrophil elastase, but this reaction was inhibited by the neutrophil elastase inhibitor ONO-5046.Na. sivelestat 201-209 elastase, neutrophil expressed Rattus norvegicus 111-130 17203197-0 2007 A neutrophil elastase inhibitor, sivelestat, ameliorates lung injury after hemorrhagic shock in rats. sivelestat 33-43 elastase, neutrophil expressed Rattus norvegicus 2-21 17024574-4 2006 ICAM-1 expression in the rat endothelial cell line (WK-5) was significantly upregulated after stimulation with neutrophil elastase, but this reaction was inhibited by the neutrophil elastase inhibitor ONO-5046.Na. sivelestat 201-209 elastase, neutrophil expressed Rattus norvegicus 171-190 16096460-0 2005 Protective effects of a selective neutrophil elastase inhibitor (sivelestat) on lipopolysaccharide-induced acute dysfunction of the pulmonary microcirculation. sivelestat 65-75 elastase, neutrophil expressed Rattus norvegicus 34-53 16980042-8 2006 Neutrophil elastase inhibitor (ONO-5046: 30 mg/kg) was delivered intravenously before ischemia and after reperfusion to prevent neutrophil activation. sivelestat 31-39 elastase, neutrophil expressed Rattus norvegicus 0-19 16096460-1 2005 OBJECTIVE: The purpose of this study was to evaluate the effect of a neutrophil elastase inhibitor, sivelestat, on lipopolysaccharide-induced acute lung injury through analysis of hemodynamic changes in the pulmonary microcirculation. sivelestat 100-110 elastase, neutrophil expressed Rattus norvegicus 69-88 16096460-16 2005 The selective neutrophil elastase inhibitor sivelestat reduces neutrophil elastase activity and attenuates acute changes in the pulmonary microcirculation. sivelestat 44-54 elastase, neutrophil expressed Rattus norvegicus 14-33 16096460-16 2005 The selective neutrophil elastase inhibitor sivelestat reduces neutrophil elastase activity and attenuates acute changes in the pulmonary microcirculation. sivelestat 44-54 elastase, neutrophil expressed Rattus norvegicus 63-82 16245075-0 2004 Effects of granulocyte colony-stimulating factor (G-CSF) and neutrophil elastase inhibitor (ONO-5046) on acid-induced lung injury in rats. sivelestat 92-100 elastase, neutrophil expressed Rattus norvegicus 61-80 16245075-2 2004 We examined the effects of the high dose of granulocyte-colony stimulating factor (G-CSF), which is capable of increasing peripheral neutrophils, and a specific neutrophil elastase inhibitor (ONO-5046) on acid lung injury in rats. sivelestat 192-200 elastase, neutrophil expressed Rattus norvegicus 161-180 11568165-0 2001 Effects of neutrophil elastase inhibitor (ONO-5046) on lung injury after intestinal ischemia-reperfusion. sivelestat 42-50 elastase, neutrophil expressed Rattus norvegicus 11-30 11568165-2 2001 Here we investigated the effects of posttreatment with a neutrophil elastase inhibitor (NEI; ONO-5046) on lung injury after intestinal I/R injury in a rat model. sivelestat 93-101 elastase, neutrophil expressed Rattus norvegicus 57-76 11553680-0 2001 A neutrophil elastase inhibitor (ONO-5046) reduces neurologic damage after spinal cord injury in rats. sivelestat 33-41 elastase, neutrophil expressed Rattus norvegicus 2-21 11104832-0 2000 Effects of lecithinized superoxide dismutase and a neutrophil elastase inhibitor (ONO-5046) on hyperoxic lung injury in rat. sivelestat 82-90 elastase, neutrophil expressed Rattus norvegicus 51-70 11104832-5 2000 N-[2-[4-2,2-dimethylpropionyloxy) phenylsulfonylamino] benzoyl]? aminoacetic acid (ONO-5046), a specific neutrophil elastase inhibitor, which was developed as a low-molecular weight inhibitor, showed protective effects against various lung injuries. sivelestat 83-91 elastase, neutrophil expressed Rattus norvegicus 105-124 11089997-4 2000 Intranasal instillation of the neutrophil elastase inhibitor ONO-5046 partially inhibited the endotoxin-induced mucus production. sivelestat 61-69 elastase, neutrophil expressed Rattus norvegicus 31-50 10452882-2 1999 In the present study, we evaluated the effect of a novel, specific neutrophil elastase inhibitor (ONO-5046) on cold-ischemia/reperfusion injury of the liver allograft in rodents. sivelestat 98-106 elastase, neutrophil expressed Rattus norvegicus 67-86 10877239-12 2000 Pretreatment with neutrophil elastase inhibitors (ONO-5046 and Eglin C) or an anti-P-selectin monoclonal antibody produced effects similar to leukocytopenia. sivelestat 50-58 elastase, neutrophil expressed Rattus norvegicus 18-37 10588515-0 1999 Neutrophil elastase inhibitor (ONO-5046) attenuates reperfusion-induced hepatic microcirculatory derangement, energy depletion and lipid peroxidation in rats. sivelestat 31-39 elastase, neutrophil expressed Rattus norvegicus 0-19 10588515-2 1999 This study investigated the effects of a neutrophil elastase inhibitor (ONO-5046) on hepatic ischemia-reperfusion injury. sivelestat 72-80 elastase, neutrophil expressed Rattus norvegicus 41-60 10588515-10 1999 This study demonstrates that treatment with ONO-5046, a neutrophil elastase inhibitor, can ameliorate ischemia-reperfusion injury of the rat liver. sivelestat 44-52 elastase, neutrophil expressed Rattus norvegicus 56-75 10452882-10 1999 These data suggest that the neutrophil elastase might cause liver damage early after reperfusion in cold-stored liver, which can be ameliorated by the administration of a specific neutrophil elastase inhibitor, ONO-5046. sivelestat 211-219 elastase, neutrophil expressed Rattus norvegicus 28-47 10452882-10 1999 These data suggest that the neutrophil elastase might cause liver damage early after reperfusion in cold-stored liver, which can be ameliorated by the administration of a specific neutrophil elastase inhibitor, ONO-5046. sivelestat 211-219 elastase, neutrophil expressed Rattus norvegicus 180-199 7671322-1 1995 A novel neutrophil elastase inhibitor, ONO-5046, was administered to BB/DR rats and DBA/1 mice immunized with type II collagen to study its effect on the development of collagen-induced arthritis (CA), an experimental model of human rheumatoid arthritis. sivelestat 39-47 elastase, neutrophil expressed Rattus norvegicus 8-27 9625488-0 1998 Hepatic clearance of ONO-5046, a novel neutrophil elastase inhibitor, in rats and in the rat perfused liver. sivelestat 21-29 elastase, neutrophil expressed Rattus norvegicus 39-58 9024309-2 1997 The ability of an inhibitor of neutrophil elastase (ONO-5046) to protect against ischemia-reperfusion injury in rat liver was investigated by measuring serum concentrations of cytokine-induced neutrophil chemoattractant. sivelestat 52-60 elastase, neutrophil expressed Rattus norvegicus 31-50 9573534-1 1998 ONO-5046 is a potent, specific and intravenously active inhibitor of neutrophil elastase. sivelestat 0-8 elastase, neutrophil expressed Rattus norvegicus 69-88 9434321-3 1997 In control study, Northern blot analysis revealed that in vitro ICAM-1 mRNA transcripts in the rat endothelial cell line (WK-5) was increased in the presence of purified NE while a specific neutrophil elastase inhibitor (ONO-5046.Na) inhibited ICAM-1 expression. sivelestat 221-229 elastase, neutrophil expressed Rattus norvegicus 170-172 9434321-3 1997 In control study, Northern blot analysis revealed that in vitro ICAM-1 mRNA transcripts in the rat endothelial cell line (WK-5) was increased in the presence of purified NE while a specific neutrophil elastase inhibitor (ONO-5046.Na) inhibited ICAM-1 expression. sivelestat 221-229 elastase, neutrophil expressed Rattus norvegicus 190-209 8623193-0 1996 Neutrophil elastase inhibitor (ONO-5046) decreases cytokine-induced neutrophil chemoattractant after reperfusion of pancreaticoduodenal transplantation in rats. sivelestat 31-39 elastase, neutrophil expressed Rattus norvegicus 0-19 8623193-1 1996 The protective effects of a neutrophil elastase inhibitor (ONO-5046) on reperfusion injury following pancreaticoduodenal transplantation in rats were studied by measuring serum concentrations of cytokine-induced neutrophil chemoattractant (CINC). sivelestat 59-67 elastase, neutrophil expressed Rattus norvegicus 28-47 8623193-13 1996 However, ONO-5046 decreased CINC production by peritoneal macrophages in response to neutrophil elastase. sivelestat 9-17 elastase, neutrophil expressed Rattus norvegicus 85-104 7587785-0 1995 Neutrophil elastase inhibitor (ONO-5046) prevents lung hemorrhage induced by lipopolysaccharide in rat model of cerulein pancreatitis. sivelestat 31-39 elastase, neutrophil expressed Rattus norvegicus 0-19 7587785-1 1995 The protective effects of a neutrophil elastase inhibitor (ONO-5046) on cerulein-induced pancreatitis followed by a septic challenge with intraperitoneal lipopolysaccharide (LPS) were studied in a rat model. sivelestat 59-67 elastase, neutrophil expressed Rattus norvegicus 28-47 31813921-1 2020 PURPOSE: Sivelestat, a neutrophil elastase inhibitor, attenuates global ischemia-induced myocardial damage and coronary endothelial dysfunction. sivelestat 9-19 elastase, neutrophil expressed Rattus norvegicus 23-42 30086801-13 2018 Thus, our result suggests that inhibiting neutropil elastase by administration of sivelestat is a promising therapeutic strategy to inhibit glial scar and promote functional recovery by upregulating angiopoietin-1 after spinal cord injury. sivelestat 82-92 elastase, neutrophil expressed Rattus norvegicus 52-60