PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33796458-0	2021	High Iodine Induces the Proliferation of Papillary and Anaplastic Thyroid Cancer Cells via AKT/Wee1/CDK1 Axis.	Iodine	5-11	cyclin dependent kinase 1	Homo sapiens	100-104	
33796458-4	2021	The transcriptome analysis showed that there were 295 differentially expressed genes (DEGs) in BCPAP and 8305C cells induced by high iodine, among which CDK1 expression associated with the proliferation of thyroid cancer cells induced by high iodine.	Iodine	133-139	cyclin dependent kinase 1	Homo sapiens	153-157	
33796458-4	2021	The transcriptome analysis showed that there were 295 differentially expressed genes (DEGs) in BCPAP and 8305C cells induced by high iodine, among which CDK1 expression associated with the proliferation of thyroid cancer cells induced by high iodine.	Iodine	243-249	cyclin dependent kinase 1	Homo sapiens	153-157	
33796458-5	2021	Moreover, the western blot analysis revealed that cells exposed to high iodine enhanced the phosphorylation activation of AKT and the expression of phospho-Wee1 (Ser642), while decreasing the expression of phospho-CDK1 (Tyr15).	Iodine	72-78	cyclin dependent kinase 1	Homo sapiens	214-218	
33796458-6	2021	Importantly, the inhibition of AKT phosphorylation revered the expression of CDK1 induced by high iodine and arrested the cell cycle in the G1 phase, decreasing the proliferation of thyroid cancer cells induced by high iodine.	Iodine	98-104	cyclin dependent kinase 1	Homo sapiens	77-81	
33796458-6	2021	Importantly, the inhibition of AKT phosphorylation revered the expression of CDK1 induced by high iodine and arrested the cell cycle in the G1 phase, decreasing the proliferation of thyroid cancer cells induced by high iodine.	Iodine	219-225	cyclin dependent kinase 1	Homo sapiens	77-81	
33796458-7	2021	Taken together, these findings suggested that high iodine induced the proliferation of thyroid cancer cells through AKT-mediated Wee1/CDK1 axis, which provided new insights into the regulation of proliferation of thyroid cancer cells by iodine.	Iodine	51-57	cyclin dependent kinase 1	Homo sapiens	134-138	
33796458-7	2021	Taken together, these findings suggested that high iodine induced the proliferation of thyroid cancer cells through AKT-mediated Wee1/CDK1 axis, which provided new insights into the regulation of proliferation of thyroid cancer cells by iodine.	Iodine	237-243	cyclin dependent kinase 1	Homo sapiens	134-138