PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35038965-2	2022	INTRODUCTION: The most common altered signaling found in aggressive iodine-refractory thyroid cancers derived from follicular cells (RAI-TC) are RTK, MAPK, PI3K, WNT, BRAF, RAS, RET, and TP53.	Iodine	68-74	tumor protein p53	Homo sapiens	187-191	
10910962-1	2000	Simultaneous labelling of 17cen and the p53 locus by multicolour FISH was used to monitor radioactive iodine-induced structural and numerical chromosome abnormalities in buccal cells from 29 hyperthyroidism and thyroid cancer patients sampled before and after therapeutic treatment.	Iodine	102-108	tumor protein p53	Homo sapiens	40-43	
25515142-12	2015	In addition, iodine-131 may upregulate GADD45 mRNA expression in HTori-3 cells, resulting in G2/M phase arrest in a p53-independent pathway.	Iodine	13-19	tumor protein p53	Homo sapiens	116-119	
28892665-6	2017	On the other hand, significantly greater GPBB immunoreactivity was observed in the basal and parabasal layers of iodine-unstained epithelium, where higher positivity for p53 and Ki67 was also showed.	Iodine	113-119	tumor protein p53	Homo sapiens	170-173	
26527121-8	2015	P53 expression in the HuH7 and HepG2 cell lines increased after internal and external irradiation with iodine-131.	Iodine	103-109	tumor protein p53	Homo sapiens	0-3	
28714021-2	2017	We found that iodine-131 reduced cell proliferation, induced apoptosis, induced p53, PIDD, t-BID (mitochondria) protein expression, suppressed cytochrome c (mitochondria) protein expression, and increased Bax protein expression, and promoted caspase-2, -3 and -9 expression levels in human cardiac muscle cells.	Iodine	14-20	tumor protein p53	Homo sapiens	80-83	
28714021-3	2017	Meanwhile, si-p53 inhibited the effects of iodine-131 on the reduction in cell proliferation and induction of apoptosis in human cardiac muscle cells through regulation of Bax/cytochrome c/caspase-3 and PIDD/caspase-2/t-BID/cytochrome c/caspase-3 signaling pathway.	Iodine	43-49	tumor protein p53	Homo sapiens	14-17	
25033896-11	2014	CONCLUSIONS: The inhibitory mechanisms of iodine on CRC acted through an increase in the level of p53 and a decrease in the level of VEGF, resulting in a decrease of MVD.	Iodine	42-48	tumor protein p53	Homo sapiens	98-101	
24764719-3	2014	Here, we report the case of a woman with TP53 mutation who was treated with adjuvant pelvic rt for stage ib uterine leiomyosarcoma in 2000, with radioactive iodine for papillary thyroid cancer in 2001, and with palliative rt to the humerus in 2010 for metastatic uterine leiomyosarcoma.	Iodine	157-163	tumor protein p53	Homo sapiens	41-45	
22829208-8	2013	Iodine-negative epithelium presented significantly higher immunoreactions for P53 and GLUT 1 in basal, parabasal, and superficial layers, respectively, whereas the reaction for Ki67 in the superficial layer was higher than that in iodine-positive epithelium (Wilcoxon signed-rank test, P < 0.05).	Iodine	0-6	tumor protein p53	Homo sapiens	78-81	
20138958-0	2010	Iodine induces apoptosis via regulating MAPKs-related p53, p21, and Bcl-xL in thyroid cancer cells.	Iodine	0-6	tumor protein p53	Homo sapiens	54-57	
20138958-6	2010	Iodine treatment decreased the level of mutant p53 including the R273H mutant that possesses anti-apoptotic features, but increased the p21 level.	Iodine	0-6	tumor protein p53	Homo sapiens	47-50	
20138958-8	2010	Moreover, iodine transiently activated the subfamily members of mitogen activated protein kinases (MAPKs) (ERK1/2, p38 and JNK1/2) which contribute to modulate p53, p21 and Bcl-xL expression.	Iodine	10-16	tumor protein p53	Homo sapiens	160-163	
20138958-10	2010	Collectively, iodine-induced apoptotic pathway is involved in the activation of MAPKs-related p21, Bcl-xL and mutant p53 regulation.	Iodine	14-20	tumor protein p53	Homo sapiens	117-120	
22027149-2	2011	Previously, we showed that molecular Iodine (I(2)) induces apoptosis in hormone responsive MCF-7 breast cancer cells, and non-apoptotic cell death in ER(-ve)-p53 mutant MDA-MB231 cells (Shrivastava, 2006).	Iodine	37-43	tumor protein p53	Homo sapiens	158-161